Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0039 | 0 | 0.5 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0039 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0326 | 0.4936 | 0.4936 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0039 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0619 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0619 | 1 | 1 |
Brugia malayi | amidase | 0.0326 | 0.4936 | 0.4936 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0619 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0326 | 0.4936 | 0.4936 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0619 | 1 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0039 | 0 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0619 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0326 | 0.4936 | 0.4936 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0039 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0161 | 0.209 | 1 |
Onchocerca volvulus | 0.0619 | 1 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0161 | 0.209 | 1 |
Schistosoma mansoni | amidase | 0.0326 | 0.4936 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0619 | 1 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0619 | 1 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0326 | 0.4936 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0326 | 0.4936 | 0.4936 |
Loa Loa (eye worm) | lipase | 0.0619 | 1 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0619 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0039 | 0 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0619 | 1 | 0.5 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0039 | 0 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0326 | 0.4936 | 0.4936 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Neurotoxicity in Mus musculus (mouse) assessed as motor impairment at 100 mg/kg, ip measured at 2 hr by rotarod test relative to control | ChEMBL. | No reference | |
Activity (ADMET) | Neurotoxicity in Mus musculus (mouse) assessed as motor impairment at 100 mg/kg, ip measured at 4 hr by rotarod test relative to control | ChEMBL. | No reference | |
Activity (ADMET) | Neurotoxicity in Mus musculus (mouse) assessed as motor impairment at 30 to 300 mg/kg, ip measured at 4 hr by rotarod test | ChEMBL. | No reference | |
Activity (ADMET) | Neurotoxicity in Mus musculus (mouse) assessed as motor impairment at 100 mg/kg, ip measured at 0.25 hr by rotarod test relative to control | ChEMBL. | No reference | |
Activity (functional) | Anticonvulsant activity in Mus musculus (mouse) assessed as protection against maximal-electric shock-induced seizures at 30 to 300 mg/kg, ip measured at 0.5 hr | ChEMBL. | No reference | |
Activity (functional) | Anticonvulsant activity in Mus musculus (mouse) assessed as protection against scMET-induced clonic seizures at 30 to 300 mg/kg, ip measured at 0.5 to 4 hr | ChEMBL. | No reference | |
Activity (ADMET) | Neurotoxicity in Mus musculus (mouse) assessed as motor impairment at 100 mg/kg, ip measured at 1 hr by rotarod test relative to control | ChEMBL. | No reference | |
Activity (functional) | Anticonvulsant activity in Mus musculus (mouse) assessed as protection against 6 Hz psychomotor-induced clonic seizures at 100 mg/kg, i.p. measured at 4 hr relative to control | ChEMBL. | No reference | |
Activity (ADMET) | Neurotoxicity in Mus musculus (mouse) assessed as motor impairment at 30 to 300 mg/kg, ip measured at 0.5 hr by rotarod test | ChEMBL. | No reference | |
Activity (ADMET) | Neurotoxicity in Mus musculus (mouse) assessed as motor impairment at 100 mg/kg, ip measured at 0.5 hr by rotarod test relative to control | ChEMBL. | No reference | |
Activity (functional) | = 50 % | Anticonvulsant activity in Mus musculus (mouse) assessed as protection against 6 Hz psychomotor-induced clonic seizures at 100 mg/kg, ip measured at 2 hr relative to control | ChEMBL. | No reference |
Activity (functional) | = 50 % | Anticonvulsant activity in Mus musculus (mouse) assessed as protection against 6 Hz psychomotor-induced clonic seizures at 100 mg/kg, i.p. measured at 1 hr relative to control | ChEMBL. | No reference |
Activity (functional) | = 50 % | Anticonvulsant activity in Mus musculus (mouse) assessed as protection against 6 Hz psychomotor-induced clonic seizures at 100 mg/kg, i.p. measured at 0.25 hr relative to control | ChEMBL. | No reference |
Activity (functional) | = 100 % | Anticonvulsant activity in Mus musculus (mouse) assessed as protection against 6 Hz psychomotor-induced clonic seizures at 100 mg/kg, i.p. measured at 0.5 hr relative to control | ChEMBL. | No reference |
MED (functional) | = 100 mg kg-1 | Anticonvulsant activity in i.p. dosed Mus musculus (mouse) assessed as protection against maximal-electric shock-induced seizures measured at 4 hr | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.