Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | poly (ADP-ribose) polymerase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.3951 | 0.5794 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0095 | 0.3951 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.007 | 0.2161 | 0.1977 |
Trypanosoma brucei | poly(adp-ribose) polymerase | 0.0095 | 0.3951 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.007 | 0.2161 | 0.1977 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0054 | 0.1002 | 0.0714 |
Brugia malayi | WGR domain containing protein | 0.0174 | 0.9517 | 1 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.2161 | 0.1977 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0095 | 0.3951 | 0.5 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0174 | 0.9517 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0095 | 0.3951 | 0.393 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.6567 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0174 | 0.9517 | 1 |
Echinococcus granulosus | WGR domain containing protein | 0.0054 | 0.1002 | 0.0714 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0174 | 0.9517 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0348 | 0.0366 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0082 | 0.3036 | 0.2931 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0174 | 0.9517 | 1 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0095 | 0.3951 | 0.393 |
Brugia malayi | WGR domain containing protein | 0.0095 | 0.3951 | 0.393 |
Loa Loa (eye worm) | poly(ADP-ribose) polymerase | 0.0068 | 0.2033 | 0.271 |
Brugia malayi | hypothetical protein | 0.007 | 0.2161 | 0.1977 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.007 | 0.2161 | 0.227 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0348 | 0.0366 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0095 | 0.3951 | 0.4152 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (binding) | = 0.5 uM | Inhibition of PARP-1 (unknown origin) expressed in CHO-K1 cells assessed as depletion of NAD(P)H after 2 hr by CCK-8 assay | ChEMBL. | No reference |
IC50 (binding) | = 0.067 uM | Inhibition of PARP-1 (unknown origin) assessed as inhibition of biotinylated poly(ADP-ribose) onto histone proteins after 30 min by colorimetry | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.