Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | brix domain-containing protein | 0.0191 | 1 | 0.5 |
Trypanosoma brucei | brix domain containing protein, putative | 0.0191 | 1 | 0.5 |
Toxoplasma gondii | brix domain-containing protein | 0.0191 | 1 | 0.5 |
Trypanosoma cruzi | peter pan protein, putative | 0.0191 | 1 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0191 | 1 | 0.5 |
Plasmodium falciparum | BRIX domain, putative | 0.0191 | 1 | 0.5 |
Entamoeba histolytica | brix domain containing protein | 0.0191 | 1 | 0.5 |
Onchocerca volvulus | Peter pan protein homolog | 0.0191 | 1 | 0.5 |
Schistosoma mansoni | peter pan-related | 0.0191 | 1 | 0.5 |
Leishmania major | peter pan protein, putative | 0.0191 | 1 | 0.5 |
Trypanosoma cruzi | peter pan protein, putative | 0.0191 | 1 | 0.5 |
Schistosoma mansoni | peter pan-related | 0.0191 | 1 | 0.5 |
Echinococcus multilocularis | peter pan | 0.0191 | 1 | 1 |
Echinococcus granulosus | peter pan | 0.0191 | 1 | 1 |
Trichomonas vaginalis | ssf, putative | 0.0191 | 1 | 0.5 |
Giardia lamblia | Peter pan protein | 0.0191 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.