Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | peter pan protein, putative | 0.013 | 0.5 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.013 | 0.5 | 0.5 |
Plasmodium falciparum | BRIX domain, putative | 0.013 | 0.5 | 0.5 |
Entamoeba histolytica | brix domain containing protein | 0.013 | 0.5 | 0.5 |
Loa Loa (eye worm) | brix domain-containing protein | 0.013 | 0.5 | 0.5 |
Toxoplasma gondii | brix domain-containing protein | 0.013 | 0.5 | 0.5 |
Trypanosoma brucei | brix domain containing protein, putative | 0.013 | 0.5 | 0.5 |
Echinococcus granulosus | peter pan | 0.013 | 0.5 | 0.5 |
Echinococcus multilocularis | peter pan | 0.013 | 0.5 | 0.5 |
Giardia lamblia | Peter pan protein | 0.013 | 0.5 | 0.5 |
Trichomonas vaginalis | ssf, putative | 0.013 | 0.5 | 0.5 |
Onchocerca volvulus | Peter pan protein homolog | 0.013 | 0.5 | 0.5 |
Trypanosoma cruzi | peter pan protein, putative | 0.013 | 0.5 | 0.5 |
Schistosoma mansoni | peter pan-related | 0.013 | 0.5 | 0.5 |
Leishmania major | peter pan protein, putative | 0.013 | 0.5 | 0.5 |
Schistosoma mansoni | peter pan-related | 0.013 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of recombinant Homo sapiens (human) Hsp90 alpha ATPase activity assessed as inorganic phosphate release by malachite green colorimetric method | ChEMBL. | No reference | |
Inhibition (binding) | = 18 % | Inhibition of recombinant Homo sapiens (human) Hsp90 alpha ATPase activity assessed as inorganic phosphate release at 10 uM by malachite green colorimetric method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.