Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0291 | 0.9991 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0208 | 0.6855 | 0.6855 |
Entamoeba histolytica | 1,4-alpha-glucan branching enzyme, putative | 0.0105 | 0.2983 | 0.3758 |
Chlamydia trachomatis | 1,4-alpha-glucan branching enzyme | 0.0105 | 0.2983 | 0.4351 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0208 | 0.6855 | 0.6861 |
Mycobacterium ulcerans | glycogen branching protein | 0.0105 | 0.2983 | 0.4351 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0236 | 0.7937 | 1 |
Toxoplasma gondii | alpha amylase, catalytic domain-containing protein | 0.0105 | 0.2983 | 1 |
Giardia lamblia | 1,4-alpha-glucan branching enzyme | 0.0105 | 0.2983 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0236 | 0.7937 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.2019 | 0.5 |
Trichomonas vaginalis | starch branching enzyme II, putative | 0.0105 | 0.2983 | 0.3758 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0208 | 0.6855 | 1 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0069 | 0.1644 | 0.1645 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0236 | 0.7937 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0079 | 0.2019 | 0.5 |
Entamoeba histolytica | alpha-amylase family protein | 0.0236 | 0.7937 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0208 | 0.6855 | 1 |
Echinococcus granulosus | glucan 14 alpha branching enzyme 1 | 0.0105 | 0.2983 | 0.4351 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0208 | 0.6855 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.021 | 0.6962 | 0.8772 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1347 | 0.1348 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.2983 | 0.2985 |
Echinococcus multilocularis | glucan (1,4 alpha), branching enzyme 1 | 0.0105 | 0.2983 | 0.4351 |
Trichomonas vaginalis | amylase, putative | 0.0236 | 0.7937 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.2019 | 0.6769 |
Brugia malayi | C1-like domain containing protein | 0.0069 | 0.1644 | 0.1644 |
Onchocerca volvulus | 0.0069 | 0.1635 | 0.7864 | |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0062 | 0.1356 | 0.1357 |
Schistosoma mansoni | dihydrofolate reductase | 0.0208 | 0.6855 | 1 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0069 | 0.1644 | 0.1644 |
Onchocerca volvulus | 0.0071 | 0.1713 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1347 | 0.1348 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1713 | 0.1715 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0208 | 0.6855 | 1 |
Mycobacterium tuberculosis | 1,4-alpha-glucan branching enzyme GlgB (glycogen branching enzyme) | 0.0105 | 0.2983 | 0.4351 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.2019 | 0.5 |
Toxoplasma gondii | 1,4-alpha-glucan-branching enzyme | 0.0105 | 0.2983 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0208 | 0.6855 | 1 |
Schistosoma mansoni | starch branching enzyme II | 0.0105 | 0.2983 | 0.4351 |
Entamoeba histolytica | alpha-amylase family protein | 0.0236 | 0.7937 | 1 |
Schistosoma mansoni | protein kinase C mu | 0.0069 | 0.1644 | 0.2398 |
Entamoeba histolytica | 1,4-alpha-glucan branching enzyme, putative | 0.0105 | 0.2983 | 0.3758 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.2019 | 0.5 |
Brugia malayi | 1,4-alpha-glucan branching enzyme | 0.0105 | 0.2983 | 0.2983 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.2019 | 0.5 |
Trichomonas vaginalis | amylase, putative | 0.0105 | 0.2983 | 0.3758 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0208 | 0.6855 | 1 |
Toxoplasma gondii | glycosyltransferase | 0.0105 | 0.2983 | 1 |
Trichomonas vaginalis | amylase, putative | 0.0236 | 0.7937 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0208 | 0.6855 | 0.6855 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0236 | 0.7937 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1635 | 0.1636 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1 uM | Inhibition of Pneumocystis carinii DHFR | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.