Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0483 | 0.9907 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0483 | 0.9907 | 1 |
Echinococcus multilocularis | dual specificity | 0.0376 | 0.7251 | 0.731 |
Loa Loa (eye worm) | haspin protein kinase | 0.0483 | 0.9907 | 0.9907 |
Entamoeba histolytica | protein kinase domain containing protein | 0.009 | 0.0093 | 0.0087 |
Entamoeba histolytica | protein kinase, putative | 0.0376 | 0.7251 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.3775 | 0.3775 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.009 | 0.0093 | 0.0087 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0376 | 0.7251 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0376 | 0.7251 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0483 | 0.9907 | 1 |
Entamoeba histolytica | hypothetical protein | 0.009 | 0.0093 | 0.0087 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0376 | 0.7251 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0167 | 0.2034 | 0.2052 |
Plasmodium vivax | hypothetical protein, conserved | 0.0237 | 0.3775 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0483 | 0.9907 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0483 | 0.9907 | 0.9907 |
Brugia malayi | GSG2 | 0.0483 | 0.9907 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0483 | 0.9907 | 1 |
Leishmania major | chitinase | 0.0149 | 0.1584 | 0.2153 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0376 | 0.7251 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0167 | 0.2034 | 0.2052 |
Brugia malayi | Endochitinase | 0.0167 | 0.2034 | 0.2029 |
Entamoeba histolytica | protein kinase, putative | 0.009 | 0.0093 | 0.0087 |
Echinococcus granulosus | dual specificity | 0.0376 | 0.7251 | 0.731 |
Onchocerca volvulus | Putative endochitinase | 0.0167 | 0.2034 | 0.2052 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.009 | 0.0093 | 0.0087 |
Loa Loa (eye worm) | CMGC/CDK/CRK7 protein kinase | 0.0087 | 0.0029 | 0.0029 |
Onchocerca volvulus | 0.0237 | 0.3775 | 1 | |
Brugia malayi | hypothetical protein | 0.0483 | 0.9907 | 1 |
Mycobacterium tuberculosis | Possible chitinase | 0.0127 | 0.1034 | 0.5 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0376 | 0.7251 | 0.7251 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0127 | 0.1034 | 0.5 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0376 | 0.7251 | 0.731 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0376 | 0.7251 | 0.731 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0376 | 0.7251 | 1 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0376 | 0.7251 | 1 |
Echinococcus multilocularis | dual specificity | 0.009 | 0.0093 | 0.0064 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0376 | 0.7251 | 1 |
Brugia malayi | endochitinase | 0.0149 | 0.1584 | 0.1574 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0376 | 0.7251 | 1 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0145 | 0.1484 | 0.1484 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0376 | 0.7251 | 1 |
Plasmodium falciparum | conserved protein, unknown function | 0.0237 | 0.3775 | 1 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0237 | 0.3775 | 0.3792 |
Brugia malayi | endochitinase | 0.0167 | 0.2034 | 0.2029 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0087 | 0.0029 | 0.0029 |
Echinococcus granulosus | dual specificity | 0.009 | 0.0093 | 0.0064 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.009 | 0.0093 | 0.0093 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.009 | 0.0093 | 0.0087 |
Echinococcus multilocularis | dual specificity | 0.0376 | 0.7251 | 0.731 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0376 | 0.7251 | 1 |
Loa Loa (eye worm) | chitinase I | 0.0149 | 0.1584 | 0.1584 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0376 | 0.7251 | 1 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0149 | 0.1584 | 0.1584 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0237 | 0.3775 | 0.3792 |
Echinococcus multilocularis | dual specificity | 0.0376 | 0.7251 | 0.731 |
Echinococcus granulosus | dual specificity | 0.0376 | 0.7251 | 0.731 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.009 | 0.0093 | 0.0087 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0127 | 0.1034 | 0.5 |
Entamoeba histolytica | chitinase, putative | 0.0149 | 0.1584 | 0.2153 |
Schistosoma mansoni | hypothetical protein | 0.0237 | 0.3775 | 0.3792 |
Entamoeba histolytica | protein kinase, putative | 0.009 | 0.0093 | 0.0087 |
Schistosoma mansoni | serine/threonine protein kinase | 0.009 | 0.0093 | 0.0064 |
Brugia malayi | Protein kinase domain containing protein | 0.009 | 0.0093 | 0.0064 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0376 | 0.7251 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0483 | 0.9907 | 1 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0237 | 0.3775 | 0.3792 |
Onchocerca volvulus | 0.0237 | 0.3775 | 1 | |
Echinococcus granulosus | dual specificity | 0.0376 | 0.7251 | 0.731 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1034 | 0.1034 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.3775 | 0.3775 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.