Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0139 | 0.1519 | 1 | |
Onchocerca volvulus | Putative endochitinase | 0.0098 | 0.0554 | 0.2052 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0089 | 0.0345 | 0.0127 |
Schistosoma mansoni | protein kinase | 0.0089 | 0.0345 | 0.0093 |
Brugia malayi | Protein kinase domain containing protein | 0.0089 | 0.0345 | 0.0042 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0386 | 0.7338 | 0.7338 |
Loa Loa (eye worm) | chitinase I | 0.0088 | 0.0304 | 0.0304 |
Echinococcus granulosus | dual specificity | 0.0386 | 0.7338 | 0.7336 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0386 | 0.7338 | 1 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0085 | 0.0249 | 0.0249 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0386 | 0.7338 | 1 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0093 | 0.0434 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0344 | 0.0344 |
Entamoeba histolytica | chitinase, putative | 0.0088 | 0.0304 | 0.007 |
Leishmania major | serine/threonine kinase-like protein, putative | 0.0089 | 0.0345 | 0.0057 |
Onchocerca volvulus | Putative endochitinase | 0.0098 | 0.0554 | 0.2052 |
Leishmania major | mitogen-activated protein kinase, putative,map kinase-like protein | 0.0089 | 0.0345 | 0.0057 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0133 | 0.1379 | 0.1164 |
Echinococcus multilocularis | dual specificity | 0.0386 | 0.7338 | 0.7336 |
Echinococcus granulosus | Cell division cycle 2 protein kinase | 0.0089 | 0.0345 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.1519 | 0.1519 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0093 | 0.0434 | 0.0127 |
Brugia malayi | Carboxylesterase family protein | 0.0133 | 0.1379 | 0.1119 |
Echinococcus granulosus | serine:threonine protein kinase NLK | 0.0089 | 0.0345 | 0.0093 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0139 | 0.1519 | 0.1309 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0386 | 0.7338 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase NLK | 0.0089 | 0.0345 | 0.0093 |
Entamoeba histolytica | protein kinase, putative | 0.0386 | 0.7338 | 1 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0386 | 0.7338 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0098 | 0.0554 | 0.2052 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0495 | 0.991 | 1 |
Onchocerca volvulus | 0.0139 | 0.1519 | 1 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0133 | 0.1379 | 0.1379 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0093 | 0.0434 | 0.0185 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0386 | 0.7338 | 0.7336 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0386 | 0.7338 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1379 | 0.1379 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0386 | 0.7338 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0093 | 0.0434 | 0.0135 |
Entamoeba histolytica | protein kinase, putative | 0.0093 | 0.0434 | 0.0252 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0093 | 0.0434 | 0.0434 |
Brugia malayi | endochitinase | 0.0098 | 0.0554 | 0.0259 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0088 | 0.0304 | 0.0304 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.1519 | 0.1519 |
Entamoeba histolytica | protein kinase, putative | 0.0093 | 0.0434 | 0.0252 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0386 | 0.7338 | 0.7322 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0089 | 0.0345 | 0.0093 |
Schistosoma mansoni | hypothetical protein | 0.0495 | 0.991 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0133 | 0.1379 | 0.1164 |
Echinococcus granulosus | dual specificity | 0.0093 | 0.0434 | 0.0185 |
Loa Loa (eye worm) | carboxylesterase | 0.0133 | 0.1379 | 0.1379 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0139 | 0.1519 | 0.1309 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0089 | 0.0345 | 0.0127 |
Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0089 | 0.0345 | 0.0042 |
Brugia malayi | Carboxylesterase family protein | 0.0133 | 0.1379 | 0.1119 |
Echinococcus granulosus | acetylcholinesterase | 0.0133 | 0.1379 | 0.1164 |
Echinococcus granulosus | dual specificity | 0.0386 | 0.7338 | 0.7336 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0075 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0386 | 0.7338 | 1 |
Mycobacterium tuberculosis | Possible chitinase | 0.0075 | 0 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0495 | 0.991 | 1 |
Brugia malayi | Cell division protein kinase 2 | 0.0089 | 0.0345 | 0.0042 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0386 | 0.7338 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CRK7 protein kinase | 0.0089 | 0.0345 | 0.0345 |
Loa Loa (eye worm) | haspin protein kinase | 0.0495 | 0.991 | 0.991 |
Echinococcus granulosus | dual specificity | 0.0386 | 0.7338 | 0.7336 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0089 | 0.0345 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1379 | 0.1379 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0089 | 0.0345 | 0.0093 |
Echinococcus multilocularis | dual specificity | 0.0093 | 0.0434 | 0.0185 |
Echinococcus multilocularis | dual specificity | 0.0386 | 0.7338 | 0.7336 |
Plasmodium falciparum | conserved protein, unknown function | 0.0139 | 0.1519 | 1 |
Brugia malayi | GSG2 | 0.0495 | 0.991 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0139 | 0.1519 | 0.1309 |
Schistosoma mansoni | serine/threonine kinase | 0.0089 | 0.0345 | 0.0093 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0386 | 0.7338 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0133 | 0.1379 | 0.1164 |
Echinococcus multilocularis | Cell division cycle 2 protein kinase | 0.0089 | 0.0345 | 0.0093 |
Brugia malayi | Endochitinase | 0.0098 | 0.0554 | 0.0259 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0093 | 0.0434 | 0.0252 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0386 | 0.7338 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 15 | 0.0089 | 0.0345 | 0.0093 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0075 | 0 | 0.5 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0093 | 0.0434 | 0.0127 |
Plasmodium vivax | hypothetical protein, conserved | 0.0139 | 0.1519 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0344 | 0.0344 |
Loa Loa (eye worm) | haspin protein kinase | 0.0495 | 0.991 | 0.991 |
Echinococcus multilocularis | acetylcholinesterase | 0.0133 | 0.1379 | 0.1164 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0139 | 0.1519 | 0.1264 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0089 | 0.0345 | 0.0345 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0386 | 0.7338 | 1 |
Echinococcus multilocularis | dual specificity | 0.0386 | 0.7338 | 0.7336 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0133 | 0.1379 | 0.1164 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0386 | 0.7338 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0495 | 0.991 | 1 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0093 | 0.0434 | 0.0127 |
Echinococcus granulosus | carboxylesterase 5A | 0.0133 | 0.1379 | 0.1164 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0495 | 0.991 | 1 |
Brugia malayi | hypothetical protein | 0.0495 | 0.991 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0495 | 0.991 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0093 | 0.0434 | 0.0252 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.