Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | 0.0094 | 0.0485 | 0.0189 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0382 | 0.7338 | 1 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0382 | 0.7338 | 1 |
Leishmania major | serine/threonine kinase-like protein, putative | 0.0088 | 0.0346 | 0.006 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0382 | 0.7338 | 1 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0088 | 0.0346 | 0.0346 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0382 | 0.7338 | 0.7336 |
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 0.1379 | 0.1163 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0382 | 0.7338 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0132 | 0.1379 | 0.1163 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0138 | 0.1517 | 0.1306 |
Schistosoma mansoni | protein kinase | 0.0088 | 0.0346 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1517 | 0.1517 |
Onchocerca volvulus | Putative endochitinase | 0.0097 | 0.0553 | 0.2052 |
Loa Loa (eye worm) | carboxylesterase | 0.0132 | 0.1379 | 0.1379 |
Brugia malayi | Endochitinase | 0.0097 | 0.0553 | 0.0259 |
Loa Loa (eye worm) | CMGC/CDK/CRK7 protein kinase | 0.0088 | 0.0346 | 0.0346 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0088 | 0.0346 | 0.0127 |
Entamoeba histolytica | hypothetical protein | 0.0094 | 0.0485 | 0.0324 |
Echinococcus granulosus | dual specificity | 0.0382 | 0.7338 | 0.7336 |
Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0088 | 0.0346 | 0.0044 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0138 | 0.1517 | 0.1306 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0138 | 0.1517 | 0.1263 |
Schistosoma mansoni | hypothetical protein | 0.0138 | 0.1517 | 0.1306 |
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 0.1379 | 0.1163 |
Echinococcus granulosus | dual specificity | 0.0094 | 0.0485 | 0.0237 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.049 | 0.991 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0382 | 0.7338 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0094 | 0.0485 | 0.0324 |
Brugia malayi | Cell division protein kinase 2 | 0.0088 | 0.0346 | 0.0044 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0382 | 0.7338 | 0.7338 |
Echinococcus granulosus | serine:threonine protein kinase NLK | 0.0088 | 0.0346 | 0.0093 |
Mycobacterium tuberculosis | Possible chitinase | 0.0074 | 0 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0382 | 0.7338 | 1 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0382 | 0.7338 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0088 | 0.0346 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1379 | 0.1379 |
Echinococcus multilocularis | dual specificity | 0.0382 | 0.7338 | 0.7336 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0382 | 0.7338 | 1 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0094 | 0.0485 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1517 | 0.1517 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0382 | 0.7338 | 0.7323 |
Brugia malayi | Carboxylesterase family protein | 0.0132 | 0.1379 | 0.1119 |
Plasmodium falciparum | conserved protein, unknown function | 0.0138 | 0.1517 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0395 | 0.0395 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0088 | 0.0346 | 0.0093 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0088 | 0.0346 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0395 | 0.0395 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0094 | 0.0485 | 0.0324 |
Echinococcus multilocularis | dual specificity | 0.0094 | 0.0485 | 0.0237 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0087 | 0.0304 | 0.0304 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 0.1379 | 0.1163 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0094 | 0.0485 | 0.0199 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0084 | 0.0249 | 0.0249 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0132 | 0.1379 | 0.1379 |
Entamoeba histolytica | protein kinase, putative | 0.0094 | 0.0485 | 0.0324 |
Echinococcus multilocularis | serine:threonine protein kinase NLK | 0.0088 | 0.0346 | 0.0093 |
Echinococcus multilocularis | Cell division cycle 2 protein kinase | 0.0088 | 0.0346 | 0.0093 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0132 | 0.1379 | 0.1163 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0382 | 0.7338 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0094 | 0.0485 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1379 | 0.1379 |
Schistosoma mansoni | serine/threonine kinase | 0.0088 | 0.0346 | 0.0093 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0094 | 0.0485 | 0.0258 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0132 | 0.1379 | 0.1163 |
Echinococcus granulosus | dual specificity | 0.0382 | 0.7338 | 0.7336 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0094 | 0.0485 | 0.0485 |
Echinococcus granulosus | dual specificity | 0.0382 | 0.7338 | 0.7336 |
Brugia malayi | Carboxylesterase family protein | 0.0132 | 0.1379 | 0.1119 |
Echinococcus granulosus | mitogen activated protein kinase 15 | 0.0088 | 0.0346 | 0.0093 |
Schistosoma mansoni | hypothetical protein | 0.049 | 0.991 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0138 | 0.1517 | 1 |
Brugia malayi | endochitinase | 0.0097 | 0.0553 | 0.0259 |
Leishmania major | mitogen-activated protein kinase, putative,map kinase-like protein | 0.0088 | 0.0346 | 0.006 |
Echinococcus multilocularis | dual specificity | 0.0382 | 0.7338 | 0.7336 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0088 | 0.0346 | 0.0127 |
Loa Loa (eye worm) | chitinase I | 0.0087 | 0.0304 | 0.0304 |
Echinococcus granulosus | Cell division cycle 2 protein kinase | 0.0088 | 0.0346 | 0.0093 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.049 | 0.991 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0088 | 0.0346 | 0.0044 |
Onchocerca volvulus | Putative endochitinase | 0.0097 | 0.0553 | 0.2052 |
Brugia malayi | hypothetical protein | 0.049 | 0.991 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.049 | 0.991 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0382 | 0.7338 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0382 | 0.7338 | 1 |
Onchocerca volvulus | 0.0138 | 0.1517 | 1 | |
Entamoeba histolytica | protein kinase, putative | 0.0382 | 0.7338 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.0485 | 0.0237 |
Onchocerca volvulus | Putative endochitinase | 0.0097 | 0.0553 | 0.2052 |
Onchocerca volvulus | 0.0138 | 0.1517 | 1 | |
Entamoeba histolytica | chitinase, putative | 0.0087 | 0.0304 | 0.0068 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 0.1379 | 0.1163 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0382 | 0.7338 | 1 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0074 | 0 | 0.5 |
Loa Loa (eye worm) | haspin protein kinase | 0.049 | 0.991 | 0.991 |
Echinococcus multilocularis | dual specificity | 0.0382 | 0.7338 | 0.7336 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.049 | 0.991 | 1 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0074 | 0 | 0.5 |
Brugia malayi | GSG2 | 0.049 | 0.991 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.049 | 0.991 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.049 | 0.991 | 0.991 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.