Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.038 | 0.7337 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0088 | 0.0343 | 0.0299 |
Onchocerca volvulus | 0.012 | 0.1113 | 1 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.038 | 0.7337 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase NLK | 0.0088 | 0.0343 | 0.0093 |
Loa Loa (eye worm) | chitinase I | 0.0076 | 0.0048 | 0.0048 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0488 | 0.991 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0312 | 0.0312 |
Trichomonas vaginalis | CMGC family protein kinase | 0.038 | 0.7337 | 1 |
Brugia malayi | hypothetical protein | 0.0488 | 0.991 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0488 | 0.991 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0488 | 0.991 | 1 |
Brugia malayi | GSG2 | 0.0488 | 0.991 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0488 | 0.991 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0488 | 0.991 | 0.991 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.012 | 0.1113 | 0.0891 |
Echinococcus multilocularis | dual specificity | 0.038 | 0.7337 | 0.7335 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0091 | 0.0402 | 0.0085 |
Leishmania major | serine/threonine kinase-like protein, putative | 0.0088 | 0.0343 | 0.0404 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0488 | 0.991 | 1 |
Echinococcus granulosus | dual specificity | 0.038 | 0.7337 | 0.7335 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0088 | 0.0343 | 0.0093 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0088 | 0.0343 | 0.0404 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0091 | 0.0402 | 0.0085 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.038 | 0.7337 | 1 |
Brugia malayi | Cell division protein kinase 2 | 0.0088 | 0.0343 | 0.0299 |
Echinococcus multilocularis | dual specificity | 0.0091 | 0.0402 | 0.0154 |
Onchocerca volvulus | Putative endochitinase | 0.0085 | 0.0267 | 0.2052 |
Entamoeba histolytica | protein kinase, putative | 0.0091 | 0.0402 | 0.0485 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0088 | 0.0343 | 0.0093 |
Entamoeba histolytica | protein kinase domain containing protein | 0.038 | 0.7337 | 1 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0091 | 0.0402 | 0.0485 |
Onchocerca volvulus | Putative endochitinase | 0.0085 | 0.0267 | 0.2052 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.038 | 0.7337 | 1 |
Leishmania major | mitogen-activated protein kinase, putative,map kinase-like protein | 0.0088 | 0.0343 | 0.0404 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.038 | 0.7337 | 0.7337 |
Entamoeba histolytica | hypothetical protein | 0.0091 | 0.0402 | 0.0485 |
Loa Loa (eye worm) | haspin protein kinase | 0.0488 | 0.991 | 0.991 |
Onchocerca volvulus | 0.012 | 0.1113 | 1 | |
Brugia malayi | endochitinase | 0.0085 | 0.0267 | 0.0222 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0091 | 0.0402 | 0.0402 |
Trichomonas vaginalis | CMGC family protein kinase | 0.038 | 0.7337 | 1 |
Echinococcus multilocularis | dual specificity | 0.038 | 0.7337 | 0.7335 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0088 | 0.0343 | 0.0404 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.038 | 0.7337 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.038 | 0.7337 | 1 |
Brugia malayi | Endochitinase | 0.0085 | 0.0267 | 0.0222 |
Echinococcus granulosus | dual specificity | 0.038 | 0.7337 | 0.7335 |
Entamoeba histolytica | hypothetical protein | 0.0084 | 0.0253 | 0.0281 |
Schistosoma mansoni | protein kinase | 0.0088 | 0.0343 | 0.0093 |
Echinococcus granulosus | Cell division cycle 2 protein kinase | 0.0088 | 0.0343 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0088 | 0.0343 | 0.0343 |
Brugia malayi | Protein kinase domain containing protein | 0.0091 | 0.0402 | 0.0359 |
Plasmodium vivax | hypothetical protein, conserved | 0.012 | 0.1113 | 1 |
Schistosoma mansoni | hypothetical protein | 0.012 | 0.1113 | 0.0891 |
Schistosoma mansoni | serine/threonine protein kinase | 0.038 | 0.7337 | 0.7335 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0091 | 0.0402 | 0.0485 |
Onchocerca volvulus | Putative endochitinase | 0.0085 | 0.0267 | 0.2052 |
Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0088 | 0.0343 | 0.0299 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.038 | 0.7337 | 1 |
Echinococcus multilocularis | dual specificity | 0.038 | 0.7337 | 0.7335 |
Plasmodium falciparum | conserved protein, unknown function | 0.012 | 0.1113 | 1 |
Echinococcus granulosus | dual specificity | 0.0091 | 0.0402 | 0.0154 |
Trichomonas vaginalis | CMGC family protein kinase | 0.038 | 0.7337 | 1 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0091 | 0.0402 | 0.0085 |
Echinococcus granulosus | dual specificity | 0.038 | 0.7337 | 0.7335 |
Trichomonas vaginalis | CMGC family protein kinase | 0.038 | 0.7337 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CRK7 protein kinase | 0.0088 | 0.0343 | 0.0343 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.012 | 0.1113 | 0.0891 |
Entamoeba histolytica | protein kinase, putative | 0.0091 | 0.0402 | 0.0485 |
Giardia lamblia | Kinase, CMGC DYRK | 0.038 | 0.7337 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1113 | 0.1113 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1113 | 0.1113 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0488 | 0.991 | 1 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.038 | 0.7337 | 0.7391 |
Echinococcus granulosus | serine:threonine protein kinase NLK | 0.0088 | 0.0343 | 0.0093 |
Schistosoma mansoni | serine/threonine kinase | 0.0088 | 0.0343 | 0.0093 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0076 | 0.0048 | 0.0048 |
Echinococcus multilocularis | Cell division cycle 2 protein kinase | 0.0088 | 0.0343 | 0.0093 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.012 | 0.1113 | 0.108 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0088 | 0.0343 | 0.0093 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0091 | 0.0402 | 0.0154 |
Echinococcus granulosus | mitogen activated protein kinase 15 | 0.0088 | 0.0343 | 0.0093 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.