Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0341 | 0.9886 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.7243 | 1 |
Leishmania major | chitinase | 0.0076 | 0.0484 | 0.0668 |
Entamoeba histolytica | chitinase, putative | 0.0076 | 0.0484 | 0.0668 |
Onchocerca volvulus | Putative endochitinase | 0.0085 | 0.0808 | 0.2052 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.2063 | 0.2063 |
Echinococcus granulosus | dual specificity | 0.0179 | 0.4157 | 0.4205 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0076 | 0.0484 | 0.0484 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0074 | 0.0412 | 0.0412 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.4043 | 0.4043 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0266 | 0.7243 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.7243 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.4043 | 0.4043 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.7243 | 1 |
Brugia malayi | Endochitinase | 0.0085 | 0.0808 | 0.0817 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0179 | 0.4157 | 0.4157 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0341 | 0.9886 | 1 |
Echinococcus multilocularis | dual specificity | 0.0179 | 0.4157 | 0.4205 |
Brugia malayi | endochitinase | 0.0076 | 0.0484 | 0.0489 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.012 | 0.2063 | 0.2086 |
Echinococcus multilocularis | dual specificity | 0.0266 | 0.7243 | 0.7326 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.7243 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.7243 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0179 | 0.4157 | 0.5739 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0266 | 0.7243 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0179 | 0.4157 | 0.5739 |
Plasmodium vivax | hypothetical protein, conserved | 0.012 | 0.2063 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0266 | 0.7243 | 0.7326 |
Mycobacterium tuberculosis | Possible chitinase | 0.0065 | 0.0088 | 0.5 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0266 | 0.7243 | 0.7243 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0266 | 0.7243 | 1 |
Echinococcus granulosus | dual specificity | 0.0266 | 0.7243 | 0.7326 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0179 | 0.4157 | 0.5739 |
Brugia malayi | endochitinase | 0.0085 | 0.0808 | 0.0817 |
Brugia malayi | GSG2 | 0.0341 | 0.9886 | 1 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.012 | 0.2063 | 0.2086 |
Schistosoma mansoni | hypothetical protein | 0.0341 | 0.9886 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0085 | 0.0808 | 0.2052 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0341 | 0.9886 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0088 | 0.0088 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.012 | 0.2063 | 0.2086 |
Echinococcus multilocularis | dual specificity | 0.0266 | 0.7243 | 0.7326 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0341 | 0.9886 | 1 |
Echinococcus granulosus | dual specificity | 0.0266 | 0.7243 | 0.7326 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0266 | 0.7243 | 0.7326 |
Entamoeba histolytica | hypothetical protein | 0.0179 | 0.4157 | 0.5739 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0179 | 0.4157 | 0.5739 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0341 | 0.9886 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0179 | 0.4157 | 0.4205 |
Loa Loa (eye worm) | chitinase I | 0.0076 | 0.0484 | 0.0484 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0065 | 0.0088 | 0.5 |
Onchocerca volvulus | Putative endochitinase | 0.0085 | 0.0808 | 0.2052 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0266 | 0.7243 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0341 | 0.9886 | 0.9886 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0179 | 0.4157 | 0.5739 |
Echinococcus multilocularis | dual specificity | 0.0266 | 0.7243 | 0.7326 |
Entamoeba histolytica | protein kinase, putative | 0.0179 | 0.4157 | 0.5739 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0266 | 0.7243 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0179 | 0.4157 | 0.4205 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.2063 | 0.2063 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0266 | 0.7243 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0341 | 0.9886 | 0.9886 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.7243 | 1 |
Onchocerca volvulus | 0.012 | 0.2063 | 1 | |
Echinococcus granulosus | dual specificity | 0.0266 | 0.7243 | 0.7326 |
Entamoeba histolytica | protein kinase, putative | 0.0266 | 0.7243 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0341 | 0.9886 | 1 |
Plasmodium falciparum | conserved protein, unknown function | 0.012 | 0.2063 | 1 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0179 | 0.4157 | 0.5739 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0065 | 0.0088 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.012 | 0.2063 | 0.2086 |
Onchocerca volvulus | 0.012 | 0.2063 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.