Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0174 | 0.1145 | 0.6617 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0255 | 0.173 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0465 | 0.0465 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0095 | 0.0095 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0095 | 0.0547 |
Echinococcus multilocularis | GPCR, family 2 | 0.0081 | 0.0465 | 0.0465 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0081 | 0.0465 | 0.0465 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0017 | 0.0007 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.1145 | 0.6617 |
Leishmania major | cathepsin L-like protease | 0.0066 | 0.0362 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0066 | 0.0362 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0007 | 0.0038 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0095 | 0.0095 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1395 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0066 | 0.0362 | 1 |
Onchocerca volvulus | 0.0052 | 0.0257 | 0.1589 | |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0007 | 0.0038 |
Echinococcus granulosus | tumor protein p63 | 0.0355 | 0.2453 | 0.2453 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0052 | 0.0257 | 0.0257 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0017 | 0.0007 | 0.0038 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0095 | 0.0095 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0095 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0242 | 0.1639 | 0.9475 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0095 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0017 | 0.0007 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0242 | 0.1639 | 0.9475 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0017 | 0.0007 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0081 | 0.0465 | 0.269 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0465 | 0.0465 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0095 | 0.0095 |
Echinococcus multilocularis | cysteine protease | 0.0017 | 0.0007 | 0.0007 |
Onchocerca volvulus | 0.003 | 0.0095 | 0.0559 | |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0081 | 0.0465 | 0.269 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0007 | 0.0038 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0242 | 0.1639 | 0.9475 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0017 | 0.0007 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0007 | 0.0038 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0017 | 0.0007 | 0.0038 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0081 | 0.0465 | 0.0465 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0257 | 0.1484 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0017 | 0.0007 | 0.0007 |
Entamoeba histolytica | cysteine protease, putative | 0.0017 | 0.0007 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Loa Loa (eye worm) | fibroinase | 0.0017 | 0.0007 | 0.0038 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0017 | 0.0007 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0095 | 0.0095 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0007 | 0.0038 |
Leishmania major | cathepsin L-like protease | 0.0066 | 0.0362 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0007 | 0.0007 |
Mycobacterium leprae | Probable imidazole glycerol-phosphate dehydratase HisB | 0.0595 | 0.4196 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Loa Loa (eye worm) | ctsf protein | 0.0017 | 0.0007 | 0.0038 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Mycobacterium tuberculosis | Probable imidazole glycerol-phosphate dehydratase HisB | 0.1206 | 0.8632 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0465 | 0.0465 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0017 | 0.0007 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0081 | 0.0465 | 0.269 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0465 | 0.0465 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0007 | 0.0038 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0095 | 0.0095 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0095 | 0.0095 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0017 | 0.0007 | 0.0007 |
Mycobacterium ulcerans | imidazoleglycerol-phosphate dehydratase | 0.1206 | 0.8632 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0095 | 0.0547 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0052 | 0.0258 | 0.7098 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0255 | 0.173 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1395 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0081 | 0.0465 | 0.0465 |
Trichomonas vaginalis | set domain proteins, putative | 0.0234 | 0.1581 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0066 | 0.0362 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0255 | 0.173 | 1 |
Onchocerca volvulus | 0.0234 | 0.1581 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0066 | 0.0362 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0017 | 0.0007 | 0.0038 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0017 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0465 | 0.269 |
Echinococcus multilocularis | tumor protein p63 | 0.0355 | 0.2453 | 0.2453 |
Brugia malayi | Pre-SET motif family protein | 0.0206 | 0.1375 | 0.7949 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0066 | 0.0362 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0017 | 0.0007 | 0.0007 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0061 | 0.032 | 0.8824 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0087 | 0.0087 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0081 | 0.0465 | 0.0465 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0007 | 0.0038 |
Echinococcus multilocularis | cysteine protease | 0.0017 | 0.0007 | 0.0007 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0007 | 0.0007 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0017 | 0.0007 | 0.0007 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.1145 | 0.1145 |
Echinococcus granulosus | cathepsin l1 | 0.0017 | 0.0007 | 0.0007 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0017 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0206 | 0.1375 | 0.7949 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0081 | 0.0465 | 0.0465 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.173 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.