Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0051 | 0.1214 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0051 | 0.1214 | 0.1214 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0653 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1173 | 0.1173 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0051 | 0.1214 | 0.4261 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0051 | 0.1214 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1173 | 0.1173 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0653 | 0.2291 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0653 | 0.2291 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1019 | 0.1019 |
Brugia malayi | MAP kinase sur-1 | 0.0051 | 0.1214 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0582 | 0.4791 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0653 | 0.5378 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1019 | 0.8391 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.1214 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0051 | 0.1214 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1019 | 0.3575 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0051 | 0.1214 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0.0388 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0051 | 0.1214 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0653 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0029 | 0.0388 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0582 | 0.0582 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0653 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.1214 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0653 | 0.2291 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0582 | 0.2042 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1019 | 0.3575 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.1214 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0051 | 0.1214 | 0.4261 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0051 | 0.1214 | 0.4261 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1019 | 0.3575 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0051 | 0.1214 | 0.4261 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1019 | 0.3575 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0653 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0051 | 0.1214 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1019 | 0.3575 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.2849 | 0.2849 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0051 | 0.1214 | 1 |
Schistosoma mansoni | beta-galactosidase | 0.0094 | 0.2849 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1019 | 0.3575 |
Echinococcus multilocularis | beta galactosidase | 0.0094 | 0.2849 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0653 | 0.2291 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0051 | 0.1214 | 0.4261 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1173 | 0.9659 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0051 | 0.1214 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.1214 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0051 | 0.1214 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0051 | 0.1214 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1173 | 0.9659 |
Echinococcus granulosus | beta galactosidase | 0.0094 | 0.2849 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1019 | 0.3575 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.