Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Zea mays | Protoporphyrinogen IX oxidase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.002 | 0.037 | 0.037 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0025 | 0.0657 | 0.0298 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0025 | 0.0657 | 0.6091 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0657 | 0.4367 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1026 | 1 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0027 | 0.0738 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0657 | 0.4367 |
Brugia malayi | SWIRM domain containing protein | 0.0025 | 0.0657 | 0.6091 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0029 | 0.0841 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0025 | 0.0657 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0025 | 0.0657 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0025 | 0.0657 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0025 | 0.0657 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0025 | 0.0657 | 0.5 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.002 | 0.037 | 0.037 |
Onchocerca volvulus | 0.0025 | 0.0657 | 0.5 | |
Echinococcus multilocularis | roundabout 2 | 0.0032 | 0.1026 | 0.0682 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0025 | 0.0657 | 0.5 |
Echinococcus granulosus | neuroglian | 0.0025 | 0.0658 | 0.0351 |
Leishmania major | UDP-galactopyranose mutase | 0.0025 | 0.0657 | 0.5 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0167 | 0.8584 | 1 |
Schistosoma mansoni | amine oxidase | 0.0025 | 0.0657 | 0.0657 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0029 | 0.0841 | 0.717 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0657 | 0.4367 |
Schistosoma mansoni | nephrin | 0.0025 | 0.0658 | 0.0658 |
Schistosoma mansoni | amine oxidase | 0.0025 | 0.0657 | 0.0657 |
Echinococcus granulosus | twitchin | 0.0025 | 0.0658 | 0.0351 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0025 | 0.0657 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0657 | 0.6091 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0025 | 0.0657 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0192 | 1 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0025 | 0.0657 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0192 | 1 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0025 | 0.0657 | 0.5 |
Echinococcus multilocularis | 0.0025 | 0.0657 | 0.0298 | |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0025 | 0.0657 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0657 | 0.4367 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0657 | 0.4367 |
Echinococcus multilocularis | neuroglian | 0.0025 | 0.0658 | 0.0299 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0025 | 0.0657 | 0.0657 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1026 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0192 | 1 | 1 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0167 | 0.8584 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0192 | 1 | 1 |
Schistosoma mansoni | vesicular amine transporter | 0.002 | 0.037 | 0.037 |
Schistosoma mansoni | cell adhesion molecule | 0.0027 | 0.0738 | 0.0738 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0738 | 0.5607 |
Echinococcus granulosus | roundabout 2 | 0.0032 | 0.1026 | 0.0799 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0657 | 0.4367 |
Plasmodium vivax | hypothetical protein, conserved | 0.0025 | 0.0657 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0025 | 0.0657 | 0.0349 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.43 | Inhibition of Zea mays (maize) protoporphyrinogen IX oxidase | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.