Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | neuropeptide F-like receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0135 | 0.0234 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0275 | 0.4096 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0095 | 0.0823 | 0.1425 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0275 | 0.4096 | 1 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | neuropeptide receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | amine GPCR | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0095 | 0.0823 | 0.1425 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0275 | 0.4096 | 0.7093 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0057 | 0.0135 | 0.0234 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0095 | 0.0823 | 0.1219 |
Schistosoma mansoni | adenoreceptor | 0.0057 | 0.0135 | 0.0234 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0601 | 1 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | histamine h1 receptor | 0.0057 | 0.0135 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0823 | 0.1219 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0095 | 0.0823 | 0.1219 |
Loa Loa (eye worm) | serotonin transporter b | 0.0095 | 0.0823 | 0.1219 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0057 | 0.0135 | 0.0234 |
Plasmodium vivax | topoisomerase I, putative | 0.0368 | 0.5775 | 1 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0275 | 0.4096 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | amine GPCR | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | opsin-like receptor | 0.0057 | 0.0135 | 0.0234 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0095 | 0.0823 | 0.1219 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0368 | 0.5775 | 1 |
Schistosoma mansoni | amine GPCR | 0.0057 | 0.0135 | 0.0234 |
Echinococcus granulosus | serotonin transporter | 0.0095 | 0.0823 | 0.0697 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | amine GPCR | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | neuropeptide receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0057 | 0.0135 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0823 | 0.1219 |
Schistosoma mansoni | biogenic amine receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0275 | 0.4096 | 0.7093 |
Echinococcus granulosus | sortilin | 0.007 | 0.0373 | 0.0241 |
Onchocerca volvulus | 0.0095 | 0.0823 | 1 | |
Schistosoma mansoni | amine GPCR | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0057 | 0.0135 | 0.0234 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0368 | 0.5775 | 1 |
Schistosoma mansoni | opsin-like receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | opsin-like receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | myosin xvIII | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | biogenic amine receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | biogenic amine receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0368 | 0.5775 | 1 |
Schistosoma mansoni | neuropeptide receptor | 0.0057 | 0.0135 | 0.0234 |
Echinococcus multilocularis | serotonin transporter | 0.0095 | 0.0823 | 0.0697 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0368 | 0.5775 | 0.5717 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0057 | 0.0135 | 0.0234 |
Brugia malayi | DNA topoisomerase I | 0.0368 | 0.5775 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0057 | 0.0135 | 0.0234 |
Plasmodium falciparum | topoisomerase I | 0.0368 | 0.5775 | 1 |
Schistosoma mansoni | neuropeptide receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0135 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0823 | 0.1219 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0368 | 0.5775 | 0.5717 |
Echinococcus multilocularis | sortilin | 0.007 | 0.0373 | 0.0241 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0095 | 0.0823 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 500 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 443 after 24 to 48 hr by serial broth dilution method | ChEMBL. | No reference |
MIC (functional) | = 1000 ug ml-1 | Antifungal activity against Candida albicans MTCC 227 after 72 hr by serial broth dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.