Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | neuropeptide receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0057 | 0.0135 | 0.0234 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0275 | 0.4096 | 1 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0095 | 0.0823 | 0.1425 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0275 | 0.4096 | 1 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0275 | 0.4096 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | opsin-like receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | amine GPCR | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0057 | 0.0135 | 0.0234 |
Plasmodium vivax | topoisomerase I, putative | 0.0368 | 0.5775 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0057 | 0.0135 | 0.0234 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0601 | 1 | 1 |
Schistosoma mansoni | adenoreceptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0057 | 0.0135 | 0.0234 |
Loa Loa (eye worm) | serotonin transporter b | 0.0095 | 0.0823 | 0.1219 |
Schistosoma mansoni | histamine h1 receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0057 | 0.0135 | 0.0234 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0095 | 0.0823 | 0.1219 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0823 | 0.1219 |
Schistosoma mansoni | amine GPCR | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0275 | 0.4096 | 0.7093 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0057 | 0.0135 | 0.0234 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0095 | 0.0823 | 0.1219 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0095 | 0.0823 | 0.1425 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0275 | 0.4096 | 0.7093 |
Echinococcus granulosus | sortilin | 0.007 | 0.0373 | 0.0241 |
Onchocerca volvulus | 0.0095 | 0.0823 | 1 | |
Schistosoma mansoni | amine GPCR | 0.0057 | 0.0135 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0823 | 0.1219 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | biogenic amine receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | amine GPCR | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | neuropeptide receptor | 0.0057 | 0.0135 | 0.0234 |
Echinococcus granulosus | serotonin transporter | 0.0095 | 0.0823 | 0.0697 |
Schistosoma mansoni | amine GPCR | 0.0057 | 0.0135 | 0.0234 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0368 | 0.5775 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0095 | 0.0823 | 0.1219 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0057 | 0.0135 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0823 | 0.1219 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0368 | 0.5775 | 0.5717 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0135 | 0.0234 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0095 | 0.0823 | 0.5 |
Echinococcus multilocularis | sortilin | 0.007 | 0.0373 | 0.0241 |
Plasmodium falciparum | topoisomerase I | 0.0368 | 0.5775 | 1 |
Brugia malayi | DNA topoisomerase I | 0.0368 | 0.5775 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0057 | 0.0135 | 0.0234 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0368 | 0.5775 | 0.5717 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | neuropeptide receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | biogenic amine receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0057 | 0.0135 | 0.0234 |
Echinococcus multilocularis | serotonin transporter | 0.0095 | 0.0823 | 0.0697 |
Schistosoma mansoni | neuropeptide receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0368 | 0.5775 | 1 |
Schistosoma mansoni | biogenic amine receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0057 | 0.0135 | 0.0234 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0368 | 0.5775 | 1 |
Schistosoma mansoni | opsin-like receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | opsin-like receptor | 0.0057 | 0.0135 | 0.0234 |
Schistosoma mansoni | myosin xvIII | 0.0057 | 0.0135 | 0.0234 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 50 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 443 after 24 to 48 hr by serial broth dilution method | ChEMBL. | No reference |
MIC (functional) | = 500 ug ml-1 | Antifungal activity against Candida albicans MTCC 227 after 72 hr by serial broth dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.