Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | rotamase | 0.0032 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.1946 | 0.1946 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0005 | 0.014 | 0.014 |
Brugia malayi | nuclear receptor RXR | 0.0005 | 0.014 | 0.014 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.1946 | 0.1946 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0025 | 0.7382 | 0.7382 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.1946 | 0.1946 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.1946 | 0.1946 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.1946 | 0.1946 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.1946 | 0.1946 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0025 | 0.7382 | 0.7594 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1946 | 0.1946 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.1946 | 0.1946 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.1946 | 0.1946 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0005 | 0.014 | 0.014 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.014 | 0.014 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.1946 | 0.1946 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.014 | 0.014 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.014 | 0.014 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.1946 | 0.1946 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.1946 | 0.1946 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.1946 | 0.1946 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0032 | 0.972 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1946 | 0.1946 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.1946 | 0.1946 |
Trichomonas vaginalis | rotamase, putative | 0.0032 | 0.972 | 0.972 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0032 | 0.972 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.1946 | 0.1946 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1946 | 0.1946 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.1946 | 0.1946 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.1946 | 0.1946 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.1946 | 0.1946 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0032 | 0.972 | 1 |
Schistosoma mansoni | flap endonuclease-1 | 0.0023 | 0.6492 | 0.6492 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.1946 | 0.1946 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.1946 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.1946 | 0.1946 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.1946 | 0.1946 |
Echinococcus granulosus | expressed protein | 0.0032 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.1946 | 0.1946 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0005 | 0.014 | 0.014 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1946 | 0.1946 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.1946 | 0.1946 |
Entamoeba histolytica | Flap nuclease, putative | 0.0025 | 0.7382 | 0.7594 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.1946 | 0.1946 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.1946 | 0.1946 |
Brugia malayi | hypothetical protein | 0.0005 | 0.014 | 0.014 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.1946 | 0.1946 |
Brugia malayi | Flap endonuclease-1 | 0.0025 | 0.7382 | 0.7382 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.1946 | 0.1946 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.1946 | 0.1946 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.001 | 0.173 | 0.178 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.1946 | 0.1946 |
Echinococcus multilocularis | expressed protein | 0.0032 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.1946 | 0.1946 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.1946 | 0.1946 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.1946 | 0.1946 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.1946 | 0.1946 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.1946 | 0.1946 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.1946 | 0.1946 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0005 | 0.014 | 0.014 |
Wolbachia endosymbiont of Brugia malayi | parvulin-like peptidyl-prolyl isomerase, PPID | 0.001 | 0.173 | 0.5 |
Echinococcus granulosus | flap endonuclease 1 | 0.0025 | 0.7382 | 0.7382 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.7382 | 0.7594 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.001 | 0.173 | 0.178 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0025 | 0.7382 | 0.7382 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.1946 | 0.1946 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.1946 | 0.1946 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.014 | 0.014 |
Brugia malayi | hypothetical protein | 0.0005 | 0.014 | 0.014 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.1946 | 0.1946 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.1946 | 0.1946 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.1946 | 0.1946 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1946 | 0.1946 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.1946 | 0.1946 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0032 | 0.972 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.1946 | 0.1946 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1946 | 0.1946 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0025 | 0.7382 | 0.7382 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.1946 | 0.1946 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.1946 | 0.1946 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.7382 | 0.7594 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0032 | 1 | 1 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0025 | 0.7382 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 1 | 1 |
Plasmodium falciparum | flap endonuclease 1 | 0.0025 | 0.7382 | 1 |
Onchocerca volvulus | 0.001 | 0.1946 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.014 | 0.014 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.1946 | 0.1946 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.1946 | 0.1946 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.1946 | 0.1946 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | 0.001 | 0.173 | 0.178 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.1946 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.1946 | 0.1946 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0005 | 0.014 | 0.014 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.1946 | 0.1946 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0032 | 0.972 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.001 | 0.173 | 0.178 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1946 | 0.1946 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0005 | 0.014 | 0.014 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.1946 | 0.1946 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.1946 | 0.1946 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.1946 | 0.1946 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.1946 | 0.1946 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0025 | 0.7382 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1946 | 0.1946 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.1946 | 0.1946 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.7382 | 0.7594 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.1946 | 0.1946 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.1946 | 0.1946 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.1946 | 0.1946 |
Toxoplasma gondii | PPIC-type PPIASE domain-containing protein | 0.001 | 0.173 | 0.178 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.1946 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.1946 | 0.1946 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0032 | 0.972 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.1946 | 0.1946 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.1946 | 0.1946 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0005 | 0.014 | 0.014 |
Trichomonas vaginalis | rotamase, putative | 0.0032 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | Antibacterial activity against Escherichia coli MTCC 443 assessed as growth inhibition at 12.5 to 1000 ug/mL after 24 hr by NCCLS broth dilution method | ChEMBL. | No reference | |
GI (functional) | Antifungal activity against Candida albicans MTCC 227 assessed as growth inhibition at 12.5 to 1000 ug/mL after 48 hr by broth dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.