Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Toxoplasma gondii | FATC domain-containing protein | 0.0024 | 0.0852 | 0.3404 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.005 | 0.2504 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3288 | 0.299 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.2504 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.2504 | 0.2172 |
Echinococcus granulosus | muscleblind protein | 0.0146 | 0.873 | 0.8674 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.2504 | 1 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.2504 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.873 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.005 | 0.2504 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.3288 | 0.3766 |
Echinococcus granulosus | serine protein kinase ATM | 0.0024 | 0.0852 | 0.0446 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0632 | 0.0724 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.0024 | 0.0852 | 0.0446 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.3288 | 0.3766 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.0018 | 0.0425 | 0.1697 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.3288 | 0.299 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.005 | 0.2504 | 0.2172 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.005 | 0.2504 | 0.2869 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0018 | 0.0425 | 0.1697 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0018 | 0.0427 | 0.0011 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.005 | 0.2504 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.873 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.2504 | 1 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0024 | 0.0852 | 0.2055 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.005 | 0.2504 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0146 | 0.873 | 0.8674 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trypanosoma brucei | phosphatidylinositol kinase related protein, putative | 0.0024 | 0.0852 | 0.3404 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3288 | 0.299 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Echinococcus multilocularis | serine protein kinase ATM | 0.0024 | 0.0852 | 0.0446 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3288 | 0.299 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.3288 | 0.3447 |
Echinococcus granulosus | mitogen activated protein kinase | 0.005 | 0.2504 | 0.2172 |
Echinococcus multilocularis | geminin | 0.0165 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.005 | 0.2504 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0852 | 0.3404 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0018 | 0.0425 | 0.1697 |
Echinococcus multilocularis | muscleblind protein | 0.0146 | 0.873 | 0.8674 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.005 | 0.2504 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3288 | 0.299 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.3288 | 0.3766 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.005 | 0.2504 | 0.2172 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.005 | 0.2504 | 0.2172 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.3288 | 0.299 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3288 | 0.299 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0852 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0018 | 0.0425 | 0.0487 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0021 | 0.0632 | 0.0997 |
Brugia malayi | Muscleblind-like protein | 0.0146 | 0.873 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.3288 | 0.3447 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0018 | 0.0425 | 0.0487 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.2504 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0024 | 0.0852 | 0.0515 |
Leishmania major | phosphatidylinositol kinase related protein, putative | 0.0018 | 0.0427 | 0.0011 |
Trypanosoma brucei | protein kinase, putative | 0.005 | 0.2504 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.005 | 0.2504 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.2504 | 1 |
Brugia malayi | RNA binding protein | 0.0062 | 0.3288 | 0.3447 |
Brugia malayi | MAP kinase sur-1 | 0.005 | 0.2504 | 0.2504 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0425 | 0.1697 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antibacterial activity against Escherichia coli NCIM 2068 after 18 to 20 hr by plate method | ChEMBL. | No reference | |
MIC (functional) | = 600 ug ml-1 | Antifungal activity against Candida albicans MTCC 227 after 24 hr by paper disk method | ChEMBL. | No reference |
MIC (functional) | = 700 ug ml-1 | Antifungal activity against Saccharomyces cerevisiae MTCC 36 after 24 hr by paper disk method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.