Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.5216 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.5216 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0077 | 0.0783 | 0.0124 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0045 | 0.007 | 0.0135 |
Brugia malayi | Heterochromatin protein 1 | 0.0074 | 0.0727 | 0.1394 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0783 | 0.1501 |
Loa Loa (eye worm) | trypsin family protein | 0.0275 | 0.5216 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0077 | 0.0783 | 0.1501 |
Brugia malayi | Trypsin family protein | 0.0275 | 0.5216 | 1 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0275 | 0.5216 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.5216 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0275 | 0.5216 | 1 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0275 | 0.5216 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0077 | 0.0783 | 1 |
Echinococcus granulosus | enteropeptidase | 0.0275 | 0.5216 | 1 |
Brugia malayi | Trypsin family protein | 0.0275 | 0.5216 | 1 |
Echinococcus multilocularis | enteropeptidase | 0.0275 | 0.5216 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0077 | 0.0783 | 0.1501 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.5216 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0275 | 0.5216 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.5216 | 1 |
Brugia malayi | hypothetical protein | 0.0275 | 0.5216 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0275 | 0.5216 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.5216 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0077 | 0.0783 | 0.1501 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0783 | 0.1501 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.5216 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0077 | 0.0783 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0275 | 0.5216 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0077 | 0.0783 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0077 | 0.0783 | 0.5 |
Onchocerca volvulus | 0.0077 | 0.0783 | 0.1501 | |
Echinococcus granulosus | Mastin | 0.0275 | 0.5216 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0074 | 0.0727 | 0.9291 |
Echinococcus multilocularis | Mastin | 0.0275 | 0.5216 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0077 | 0.0783 | 0.5 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0275 | 0.5216 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0077 | 0.0783 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.5216 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0077 | 0.0783 | 1 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0275 | 0.5216 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.5216 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0074 | 0.0727 | 0.9291 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.5216 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0275 | 0.5216 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.5216 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0077 | 0.0783 | 0.0124 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0275 | 0.5216 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.5216 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.5216 | 1 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0275 | 0.5216 | 1 |
Onchocerca volvulus | 0.0275 | 0.5216 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.5216 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.5216 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0783 | 0.1501 |
Trichomonas vaginalis | chromobox protein, putative | 0.0045 | 0.007 | 0.09 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0074 | 0.0727 | 0.1394 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0077 | 0.0783 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0077 | 0.0783 | 0.0124 |
Brugia malayi | Trypsin family protein | 0.0275 | 0.5216 | 1 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0275 | 0.5216 | 1 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0275 | 0.5216 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0077 | 0.0783 | 0.5 |
Onchocerca volvulus | 0.0275 | 0.5216 | 1 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0077 | 0.0783 | 1 |
Onchocerca volvulus | 0.0275 | 0.5216 | 1 | |
Brugia malayi | beta-lactamase | 0.0077 | 0.0783 | 0.1501 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0783 | 0.1501 |
Trichomonas vaginalis | chromobox protein, putative | 0.0045 | 0.007 | 0.09 |
Onchocerca volvulus | 0.0275 | 0.5216 | 1 | |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0077 | 0.0783 | 0.1501 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0783 | 0.1501 |
Onchocerca volvulus | 0.0077 | 0.0783 | 0.1501 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0077 | 0.0783 | 0.0124 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.5216 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0077 | 0.0783 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0275 | 0.5216 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0077 | 0.0783 | 1 |
Onchocerca volvulus | 0.0275 | 0.5216 | 1 | |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0275 | 0.5216 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0077 | 0.0783 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0077 | 0.0783 | 0.1501 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0275 | 0.5216 | 1 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0275 | 0.5216 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0275 | 0.5216 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0783 | 0.1501 |
Onchocerca volvulus | 0.0275 | 0.5216 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0275 | 0.5216 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.5216 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.5216 | 1 |
Onchocerca volvulus | 0.0077 | 0.0783 | 0.1501 | |
Brugia malayi | Trypsin family protein | 0.0275 | 0.5216 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0077 | 0.0783 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0275 | 0.5216 | 1 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0275 | 0.5216 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1 | Inhibition of Homo sapiens (human) PTP1B expressed in Escherichia coli using PNPP as substrate | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.