TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 586.67 | Formula: C32H42O10
H donors: 2 H acceptors: 5 LogP: 2.05 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: COC(=O)C[C@H]1[C@@]2(C)[C@H](O[C@H]3C2=C(C)[C@@H](C3)C2=CC(OC2=O)O)[C@H]2[C@@H]3[C@]1(C)[C@@H](OC(=O)/C(=C/C)/C)C[C@H]([C@@]3(C)CO2)O
InChi: 1S/C32H42O10/c1-8-14(2)28(36)41-21-12-20(33)30(4)13-39-25-26(30)31(21,5)19(11-22(34)38-7)32(6)24-15(3)16(9-18(24)40-27(25)32)17-10-23(35)42-29(17)37/h8,10,16,18-21,23,25-27,33,35H,9,11-13H2,1-7H3/b14-8+/t16-,18-,19-,20-,21+,23?,25-,26+,27-,30-,31+,32-/m1/s1
InChiKey: XXNRCIYKNVWIRZ-CACFRWDFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0098	0.0784	0.0931
Echinococcus granulosus	Mastin	0.0065	0.0209	0.014
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0375	0.5714	0.7392
Trichomonas vaginalis	conserved hypothetical protein	0.0117	0.1123	0.1713
Onchocerca volvulus		0.0058	0.0074	0.0075
Brugia malayi	celfurPC protein	0.0487	0.7703	0.7839
Echinococcus granulosus	glycine receptor subunit beta	0.0098	0.0784	0.0732
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0098	0.0784	0.0931
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0247	0.0252
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0065	0.0209	0.0209
Echinococcus granulosus	glycine receptor subunit beta	0.0098	0.0784	0.0732
Giardia lamblia	High cysteine membrane protein Group 2	0.0224	0.3035	1
Schistosoma mansoni	nAChR subunit	0.0098	0.0784	0.0784
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0074	0.0075
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0065	0.0209	0.014
Echinococcus granulosus	G protein coupled receptor kinase 1	0.0085	0.0552	0.0493
Onchocerca volvulus		0.0065	0.0209	0.0213
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0375	0.5714	0.5811
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0167	0.2019	0.2019
Brugia malayi	endoprotease bli-4 precursor	0.0603	0.9779	0.9952
Trichomonas vaginalis	conserved hypothetical protein	0.0117	0.1123	0.1713
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0065	0.0209	0.0209
Loa Loa (eye worm)	endoprotease bli-4	0.0603	0.9779	0.9952
Onchocerca volvulus	Putative nachr subunit	0.0375	0.5714	0.5815
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0065	0.0209	0.0209
Brugia malayi	Cation transporter family protein	0.0167	0.2019	0.2054
Onchocerca volvulus		0.0606	0.9826	1
Brugia malayi	Cation transporter family protein	0.0098	0.0784	0.0798
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0367	0.557	0.5663
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0784	0.0798
Echinococcus granulosus	enteropeptidase	0.0065	0.0209	0.014
Loa Loa (eye worm)	hypothetical protein	0.0603	0.9779	0.9952
Brugia malayi	Trypsin family protein	0.0606	0.9826	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0143	0.1582	0.2568
Trichomonas vaginalis	conserved hypothetical protein	0.0117	0.1123	0.1713
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0209	0.0209
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0143	0.1582	0.2568
Trichomonas vaginalis	conserved hypothetical protein	0.0117	0.1123	0.1713
Loa Loa (eye worm)	hypothetical protein	0.0606	0.9826	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0784	0.0798
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0098	0.0784	0.0798
Brugia malayi	neuroendocrine convertase 1 precursor	0.0379	0.5791	0.5893
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0784	0.0798
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.0085	0.0552	0.0627
Onchocerca volvulus		0.0058	0.0074	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0167	0.2019	0.2054
Echinococcus multilocularis	transmembrane protease serine 3	0.0065	0.0209	0.0177
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0098	0.0784	0.0798
Brugia malayi	hypothetical protein	0.0058	0.0074	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0074	0.0075
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0209	0.0209
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0098	0.0784	0.0931
Brugia malayi	proprotein convertase 2	0.0379	0.5791	0.5893
Brugia malayi	hypothetical protein	0.0065	0.0209	0.0213
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0098	0.0784	0.0784
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0784	0.0798
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0098	0.0784	0.0732
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0065	0.0209	0.0209
Trichomonas vaginalis	conserved hypothetical protein	0.0117	0.1123	0.1713
Loa Loa (eye worm)	pregnancy-associated plasma protein-E	0.0058	0.0074	0.0075
Trichomonas vaginalis	conserved hypothetical protein	0.0117	0.1123	0.1713
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0784	0.0798
Loa Loa (eye worm)	trypsin family protein	0.0065	0.0209	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0375	0.5714	0.5815
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0375	0.5714	0.5815
Loa Loa (eye worm)	hypothetical protein	0.0606	0.9826	1
Onchocerca volvulus		0.0167	0.2019	0.2054
Loa Loa (eye worm)	proprotein convertase 2	0.0143	0.1582	0.161
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0098	0.0784	0.0798
Brugia malayi	hypothetical protein	0.0058	0.0074	0.0075
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0065	0.0209	0.0177
Echinococcus multilocularis	Furin 1	0.0143	0.1582	0.1976
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0784	0.0798
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0784	0.0798
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0098	0.0784	0.0784
Schistosoma mansoni	nAChR subunit	0.0098	0.0784	0.0784
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0209	0.0209
Loa Loa (eye worm)	LGC-31 protein	0.0098	0.0784	0.0798
Plasmodium vivax	apical sushi protein, putative	0.0058	0.0074	0.5
Echinococcus multilocularis	glycoprotein Antigen 5	0.0065	0.0209	0.0177
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0209	0.0209
Brugia malayi	hypothetical protein	0.0058	0.0074	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0784	0.0798
Echinococcus granulosus	furin	0.0603	0.9779	1
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0375	0.5714	0.5815
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0143	0.1582	0.2568
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0098	0.0784	0.0798
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0094	0.0726	0.0739
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0098	0.0784	0.0798
Loa Loa (eye worm)	hypothetical protein	0.0167	0.2019	0.2054
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0117	0.1123	0.1713
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0784	0.0798
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0784	0.0798
Echinococcus granulosus	nAChR subunit	0.0098	0.0784	0.0732
Onchocerca volvulus		0.0167	0.2019	0.2054
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0098	0.0784	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0784	0.0798
Loa Loa (eye worm)	ACC-1 protein	0.0098	0.0784	0.0798
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0098	0.0784	0.0798
Trichomonas vaginalis	conserved hypothetical protein	0.0117	0.1123	0.1713
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0367	0.557	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0098	0.0784	0.0732
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0098	0.0784	0.0798
Schistosoma mansoni	furin-1 (S08 family)	0.0262	0.3715	0.3715
Brugia malayi	hypothetical protein	0.0058	0.0074	0.0075
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0098	0.0784	0.0931
Loa Loa (eye worm)	hypothetical protein	0.0237	0.3257	0.3314
Onchocerca volvulus		0.0058	0.0074	0.0075
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0209	0.0209
Onchocerca volvulus		0.0058	0.0074	0.0075
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0098	0.0784	0.0784
Mycobacterium ulcerans	hypothetical protein	0.0065	0.0209	0.5
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0375	0.5714	0.5811
Onchocerca volvulus		0.0098	0.0784	0.0798
Onchocerca volvulus		0.0065	0.0209	0.0213
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0098	0.0784	0.0798
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0065	0.0209	0.0213
Onchocerca volvulus		0.0167	0.2019	0.2054
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0098	0.0784	0.0732
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0375	0.5714	0.7392
Brugia malayi	Trypsin family protein	0.0065	0.0209	0.0213
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0117	0.1123	0.1713
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0209	0.0209
Brugia malayi	Sushi domain	0.0058	0.0074	0.0075
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0367	0.557	1
Brugia malayi	Trypsin family protein	0.0065	0.0209	0.0213
Brugia malayi	hypothetical protein	0.0058	0.0074	0.0075
Schistosoma mansoni	hypothetical protein	0.0065	0.0203	0.0203
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0606	0.9826	0.9826
Echinococcus multilocularis	nAChR subunit	0.0098	0.0784	0.0931
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0117	0.1123	0.1713
Schistosoma mansoni	c4b-binding protein beta chain	0.0058	0.0074	0.0074
Echinococcus multilocularis		0.0487	0.7703	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.0213
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0098	0.0784	0.0798
Toxoplasma gondii	rhoptry neck protein RON1	0.0058	0.0074	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0098	0.0784	0.0931
Brugia malayi	Cation transporter family protein	0.0098	0.0784	0.0798
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0098	0.0784	0.0784
Schistosoma mansoni	nAChR subunit	0.0098	0.0784	0.0784
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0074	0.0075
Echinococcus granulosus	glycoprotein Antigen 5	0.0065	0.0209	0.014
Brugia malayi	GCC2 and GCC3 family protein	0.0058	0.0074	0.0075
Onchocerca volvulus		0.0541	0.8664	0.8817
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0167	0.2019	0.2019
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0065	0.0209	0.0209
Trichomonas vaginalis	conserved hypothetical protein	0.0117	0.1123	0.1713
Onchocerca volvulus		0.0058	0.0074	0.0075
Schistosoma mansoni	nAChR subunit	0.0098	0.0784	0.0784
Brugia malayi	hypothetical protein	0.0058	0.0074	0.0075
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0603	0.9779	0.9779
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0074	0.0075
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0065	0.0209	0.0177
Onchocerca volvulus		0.0065	0.0209	0.0213
Schistosoma mansoni	nAChR subunit	0.0098	0.0784	0.0784
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0209	0.0209
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0209	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0074	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1217	0.1239
Brugia malayi	pregnancy-associated plasma protein-A	0.0058	0.0074	0.0075
Onchocerca volvulus		0.0058	0.0074	0.0075
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0065	0.0209	0.014
Onchocerca volvulus		0.0065	0.0209	0.0213
Schistosoma mansoni	hypothetical protein	0.0065	0.0209	0.0209
Echinococcus multilocularis	enteropeptidase	0.0065	0.0209	0.0177
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0098	0.0784	0.0931
Echinococcus granulosus	neuroendocrine convertase 2	0.0379	0.5791	0.5891
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0094	0.0726	0.0672
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0098	0.0784	0.0798
Toxoplasma gondii	rhoptry neck protein RON9	0.0058	0.0074	1
Echinococcus granulosus	Furin 1	0.0143	0.1582	0.1553
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0784	0.0798
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0098	0.0784	0.0798
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0375	0.5714	0.7392
Trichomonas vaginalis	hypothetical protein	0.0117	0.1123	0.1713
Brugia malayi	Trypsin-like protease protein 5	0.0065	0.0209	0.0213
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0143	0.1582	0.2568
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.0213
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0098	0.0784	0.0798
Trichomonas vaginalis	conserved hypothetical protein	0.0117	0.1123	0.1713
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0098	0.0784	0.0798
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0784	0.0798
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0098	0.0784	0.0732
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0209	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0784	0.0798
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0098	0.0784	0.0798
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0098	0.0784	0.0798
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0065	0.0209	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0784	0.0798
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0784	0.0798
Loa Loa (eye worm)	ACC-1 protein	0.0098	0.0784	0.0798
Onchocerca volvulus		0.0058	0.0074	0.0075
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0367	0.557	0.7203
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0098	0.0784	0.0732
Echinococcus multilocularis	glycine receptor subunit beta	0.0098	0.0784	0.0931
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0098	0.0784	0.0732
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0375	0.5714	0.5811
Onchocerca volvulus		0.0058	0.0074	0.0075
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0098	0.0784	0.0732
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0098	0.0784	0.0798
Echinococcus granulosus	protein will die slowly	0.0065	0.0203	0.0133
Brugia malayi	Trypsin family protein	0.0065	0.0209	0.0213
Echinococcus multilocularis	protein will die slowly	0.0065	0.0203	0.017
Echinococcus multilocularis	glycine receptor subunit beta	0.0098	0.0784	0.0931
Brugia malayi	excitatory GABA receptor EXP-1A	0.0098	0.0784	0.0798
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0074	0.0075
Onchocerca volvulus		0.0058	0.0074	0.0075
Schistosoma mansoni	nAChR subunit	0.0098	0.0784	0.0784
Trichomonas vaginalis	conserved hypothetical protein	0.0117	0.1123	0.1713
Onchocerca volvulus		0.0087	0.0595	0.0606
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0143	0.1582	0.1582
Echinococcus multilocularis	Mastin	0.0065	0.0209	0.0177
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0209	0.0209
Schistosoma mansoni	nAChR subunit	0.0098	0.0784	0.0784
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0074	0.0075
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0209	0.0209
Schistosoma mansoni	serine/threonine protein kinase	0.0094	0.0726	0.0726
Trichomonas vaginalis	conserved hypothetical protein	0.0117	0.1123	0.1713
Onchocerca volvulus		0.0058	0.0074	0.0075
Echinococcus granulosus	transmembrane protease serine 3	0.0065	0.0209	0.014
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.0213
Onchocerca volvulus		0.0065	0.0209	0.0213
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0143	0.1582	0.2568
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0098	0.0784	0.0798
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0143	0.1582	0.2568
Brugia malayi	hypothetical protein	0.0058	0.0074	0.0075
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0098	0.0784	0.0798
Loa Loa (eye worm)	WD40 repeat protein	0.0065	0.0203	0.0207
Brugia malayi	Will die slowly protein	0.0065	0.0203	0.0207
Schistosoma mansoni	hypothetical protein	0.0065	0.0209	0.0209
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0098	0.0784	0.0931
Schistosoma mansoni	hypothetical protein	0.0117	0.1123	0.1123
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0094	0.0726	0.0855
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0074	0.0075
Schistosoma mansoni	serine/threonine protein kinase	0.0094	0.0726	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.0213
Plasmodium falciparum	apical sushi protein	0.0058	0.0074	0.5
Onchocerca volvulus		0.0065	0.0203	0.0207
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0098	0.0784	0.0798
Onchocerca volvulus		0.0098	0.0784	0.0798
Onchocerca volvulus		0.0098	0.0784	0.0798
Echinococcus multilocularis	neuroendocrine convertase 2	0.0379	0.5791	0.7494
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0098	0.0784	0.0798

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2288876

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1808718