Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear receptor RXR | 0.012 | 0.327 | 0.327 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0254 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0254 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | nuclear receptor | 0.012 | 0.327 | 0.327 |
Toxoplasma gondii | GHMP kinase, N-terminal domain-containing protein | 0.0083 | 0.1427 | 1 |
Trypanosoma cruzi | galactokinase-like protein, putative | 0.0155 | 0.5048 | 0.813 |
Loa Loa (eye worm) | galactokinase | 0.0083 | 0.1427 | 0.1427 |
Brugia malayi | nuclear receptor NHR-88 | 0.012 | 0.327 | 0.327 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0254 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 0.0055 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0254 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0254 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0254 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0254 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0254 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0254 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.012 | 0.327 | 0.327 |
Mycobacterium tuberculosis | Probable galactokinase GalK (galactose kinase) | 0.0178 | 0.6209 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0134 | 0.3991 | 0.3991 |
Brugia malayi | tailless protein | 0.012 | 0.327 | 0.327 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | thyroid hormone receptor | 0.0254 | 1 | 1 |
Echinococcus granulosus | galactokinase | 0.0178 | 0.6209 | 0.6209 |
Trypanosoma cruzi | galactokinase, putative | 0.0178 | 0.6209 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0254 | 1 | 1 |
Trypanosoma brucei | galactokinase-like protein, putative | 0.0118 | 0.3204 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.3991 | 0.3991 |
Trichomonas vaginalis | galactokinase, putative | 0.0083 | 0.1427 | 0.5 |
Trypanosoma cruzi | galactokinase, putative | 0.0155 | 0.5048 | 0.813 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0254 | 1 | 1 |
Schistosoma mansoni | galactokinase | 0.0083 | 0.1427 | 0.1427 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 1 | 1 |
Leishmania major | galactokinase-like protein | 0.0178 | 0.6209 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Brugia malayi | steroid hormone receptor | 0.0254 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0254 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0254 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0134 | 0.3991 | 0.3991 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0254 | 1 | 1 |
Mycobacterium ulcerans | galactokinase | 0.0178 | 0.6209 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 1 | 1 |
Trichomonas vaginalis | galactokinase, putative | 0.0083 | 0.1427 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0254 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0134 | 0.3991 | 0.3991 |
Echinococcus multilocularis | galactokinase | 0.0178 | 0.6209 | 0.6209 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0254 | 1 | 1 |
Echinococcus granulosus | N acetylgalactosamine kinase | 0.0083 | 0.1427 | 0.1427 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0254 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0254 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0254 | 1 | 1 |
Mycobacterium leprae | Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) | 0.0055 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.012 | 0.327 | 0.327 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0254 | 1 | 1 |
Brugia malayi | galactokinase family protein | 0.0083 | 0.1427 | 0.1427 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0254 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0254 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0134 | 0.3991 | 0.3991 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0254 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0254 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.3991 | 0.3991 |
Brugia malayi | nuclear receptor NHR-67 | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0254 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.012 | 0.327 | 0.327 |
Brugia malayi | nuclear hormone receptor | 0.0254 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | coup transcription factor | 0.0254 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0254 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0134 | 0.3991 | 0.3991 |
Schistosoma mansoni | nuclear hormone receptor | 0.012 | 0.327 | 0.327 |
Entamoeba histolytica | galactokinase, putative | 0.0178 | 0.6209 | 0.5 |
Onchocerca volvulus | 0.0254 | 1 | 1 | |
Brugia malayi | conserved hypotetical protein | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0254 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0254 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0254 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0254 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0254 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Brugia malayi | hypothetical protein | 0.0134 | 0.3991 | 0.3991 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.3991 | 0.3991 |
Brugia malayi | nuclear receptor RXR | 0.0134 | 0.3991 | 0.3991 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Trichomonas vaginalis | galactokinase, putative | 0.0083 | 0.1427 | 0.5 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | zinc finger protein | 0.012 | 0.327 | 0.327 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0254 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.012 | 0.327 | 0.327 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0254 | 1 | 1 |
Echinococcus multilocularis | N acetylgalactosamine kinase | 0.0083 | 0.1427 | 0.1427 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.3991 | 0.3991 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.012 | 0.327 | 0.327 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0254 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0134 | 0.3991 | 0.3991 |
Brugia malayi | ecdysone receptor | 0.012 | 0.327 | 0.327 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.012 | 0.327 | 0.327 |
Brugia malayi | Nuclear hormone receptor E75 | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0254 | 1 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.012 | 0.327 | 0.327 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0254 | 1 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.012 | 0.327 | 0.327 |
Trichomonas vaginalis | galactokinase, putative | 0.0083 | 0.1427 | 0.5 |
Schistosoma mansoni | nuclear receptor | 0.012 | 0.327 | 0.327 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0134 | 0.3991 | 0.3991 |
Schistosoma mansoni | nuclear hormone receptor | 0.012 | 0.327 | 0.327 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0254 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0254 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0254 | 1 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.012 | 0.327 | 0.327 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0134 | 0.3991 | 0.3991 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0254 | 1 | 1 |
Giardia lamblia | Mevalonate kinase | 0.0055 | 0 | 0.5 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.012 | 0.327 | 0.327 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0254 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0254 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.012 | 0.327 | 0.327 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.012 | 0.327 | 0.327 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.012 | 0.327 | 0.327 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0254 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.3991 | 0.3991 |
Loa Loa (eye worm) | DR-78 | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.327 | 0.327 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0254 | 1 | 1 |
Treponema pallidum | galactokinase | 0.0155 | 0.5048 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 1 | 1 |
Trypanosoma cruzi | galactokinase, putative | 0.0178 | 0.6209 | 1 |
Brugia malayi | hypothetical protein | 0.012 | 0.327 | 0.327 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.