TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 371.765 | Formula: C15H9ClF3N3OS
H donors: 2 H acceptors: 2 LogP: 4.79 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1cc(ccc1Cl)C(F)(F)F)Nc1nc2c(s1)cccc2
InChi: 1S/C15H9ClF3N3OS/c16-9-6-5-8(15(17,18)19)7-11(9)20-13(23)22-14-21-10-3-1-2-4-12(10)24-14/h1-7H,(H2,20,21,22,23)
InChiKey: WDECKWNNTFLSNB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.1839	0.5274
Onchocerca volvulus		0.0063	0.0918	0.499
Echinococcus granulosus	cathepsin b	0.0428	1	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0063	0.0918	0.0808
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0063	0.0918	0.0686
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.01	0.1839	0.5274
Brugia malayi	Serotonin receptor	0.0063	0.0918	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Plasmodium vivax	vivapain-2	0.01	0.1839	1
Entamoeba histolytica	cysteine proteinase, putative	0.01	0.1839	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0044	0.0447	0.0203
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0918	0.0686
Onchocerca volvulus		0.0063	0.0918	0.499
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0063	0.0918	0.0686
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.01	0.1839	0.5274
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.0918	0.0686
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0063	0.0918	0.0808
Schistosoma mansoni	hypothetical protein	0.0063	0.0918	0.0686
Echinococcus multilocularis	neuropeptide receptor	0.0063	0.0918	0.0808
Echinococcus granulosus	neuropeptides capa receptor	0.0063	0.0918	0.0686
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0063	0.0918	0.0686
Echinococcus multilocularis	fmrfamide receptor	0.0063	0.0918	0.0808
Echinococcus multilocularis	G protein coupled receptor 139	0.0063	0.0918	0.0808
Echinococcus multilocularis	cathepsin b	0.0428	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.01	0.1839	0.1631
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Echinococcus granulosus	cathepsin b	0.0428	1	1
Brugia malayi	hypothetical protein	0.0063	0.0918	0.0686
Brugia malayi	GnHR receptor homolog	0.0063	0.0918	0.0686
Echinococcus granulosus	tm gpcr rhodopsin	0.0063	0.0918	0.0686
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0063	0.0918	0.0918
Brugia malayi	RE15519p	0.0063	0.0918	0.0686
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.01	0.1839	0.5274
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0063	0.0918	0.0686
Brugia malayi	Papain family cysteine protease containing protein	0.01	0.1839	0.1631
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0249	0.0249
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.1839	0.5274
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0044	0.0447	0.0203
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0063	0.0918	0.0808
Brugia malayi	Dopamine receptor protein 1	0.0063	0.0918	0.0686
Entamoeba histolytica	cysteine proteinase, putative	0.01	0.1839	1
Schistosoma mansoni	opsin-like receptor	0.0063	0.0918	0.0686
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0063	0.0918	0.0686
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0063	0.0918	0.499
Echinococcus granulosus	fmrfamide receptor	0.0063	0.0918	0.0686
Echinococcus multilocularis	neuropeptides capa receptor	0.0063	0.0918	0.0808
Onchocerca volvulus		0.0063	0.0918	0.499
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0157	0.3265	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.1839	0.5274
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0063	0.0918	0.0686
Echinococcus granulosus	dro:myosuppressin receptor	0.0063	0.0918	0.0686
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0036	0.0249	0.0249
Onchocerca volvulus		0.01	0.1839	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.01	0.1839	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0428	1	1
Brugia malayi	G-protein coupled receptor	0.0063	0.0918	0.0686
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0063	0.0918	0.0686
Echinococcus granulosus	cathepsin l1	0.01	0.1839	0.1631
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Echinococcus granulosus	neuropeptide Y receptor	0.0063	0.0918	0.0686
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.01	0.1839	0.1631
Echinococcus granulosus	serotonin receptor	0.0063	0.0918	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0157	0.3265	0.3093
Onchocerca volvulus	Cathepsin L homolog	0.01	0.1839	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0063	0.0918	0.0808
Brugia malayi	hypothetical protein	0.0063	0.0918	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Brugia malayi	Cathepsin L-like precursor	0.01	0.1839	0.1631
Echinococcus multilocularis	cathepsin L cysteine protease	0.01	0.1839	0.174
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.01	0.1839	0.5274
Schistosoma mansoni	neuropeptide receptor	0.0063	0.0918	0.0686
Onchocerca volvulus		0.0063	0.0918	0.499
Brugia malayi	follicle stimulating hormone receptor	0.0063	0.0918	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0036	0.0249	0.0249
Onchocerca volvulus		0.01	0.1839	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0063	0.0918	0.0686
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.1839	0.5274
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0063	0.0918	0.0686
Brugia malayi	Cathepsin L-like precursor	0.01	0.1839	0.1631
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.0918	0.0686
Echinococcus granulosus	orexin receptor type 2	0.0063	0.0918	0.0686
Echinococcus multilocularis	neuropeptide receptor	0.0063	0.0918	0.0808
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0918	0.0808
Onchocerca volvulus		0.0063	0.0918	0.499
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.1839	0.5274
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0918	0.0686
Brugia malayi	hypothetical protein	0.0063	0.0918	0.0686
Echinococcus granulosus	cathepsin L cysteine proteinase	0.01	0.1839	0.1631
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Echinococcus granulosus	calpain A	0.0044	0.0447	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Giardia lamblia	Cathepsin B precursor	0.0157	0.3265	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.01	0.1839	0.5274
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Schistosoma mansoni	neuropeptide F-like receptor	0.0063	0.0918	0.0686
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0063	0.0918	0.0686
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.1839	0.5274
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.1839	0.5274
Echinococcus multilocularis	dro:myosuppressin receptor	0.0063	0.0918	0.0808
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0918	0.0686
Onchocerca volvulus	Cathepsin L homolog	0.01	0.1839	1
Echinococcus granulosus	neuropeptide receptor A26	0.0063	0.0918	0.0686
Onchocerca volvulus		0.0063	0.0918	0.499
Brugia malayi	Cathepsin L-like precursor	0.01	0.1839	0.1631
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.01	0.1839	0.5274
Loa Loa (eye worm)	TYRA-2 protein	0.0063	0.0918	0.0918
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.01	0.1839	0.5274
Brugia malayi	hypothetical protein	0.0063	0.0918	0.0686
Schistosoma mansoni	cathepsin F (C01 family)	0.01	0.1839	0.1631
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0063	0.0918	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0428	1	1
Toxoplasma gondii	cathepsin CPL	0.01	0.1839	0.5274
Echinococcus multilocularis	cathepsin b	0.0428	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.01	0.1839	0.1631
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0063	0.0918	0.0808
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0063	0.0918	0.0686
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0428	1	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0036	0.0249	0.0249
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0063	0.0918	0.0918
Schistosoma mansoni	myosin xvIII	0.0063	0.0918	0.0686
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0918	0.0808
Echinococcus multilocularis	somatostatin receptor	0.0063	0.0918	0.0808
Onchocerca volvulus		0.0036	0.0249	0.1352
Brugia malayi	putative neuropeptide receptor	0.0063	0.0918	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Onchocerca volvulus		0.0063	0.0918	0.499
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0918	0.0808
Onchocerca volvulus		0.0063	0.0918	0.499
Brugia malayi	calpain family protein 1	0.0042	0.0399	0.0154
Brugia malayi	G protein-coupled receptor F59B2.13	0.0063	0.0918	0.0686
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0063	0.0918	0.0686
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.0918	0.0686
Schistosoma mansoni	hypothetical protein	0.0063	0.0918	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0063	0.0918	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0157	0.3265	0.3093
Loa Loa (eye worm)	neuropeptide F receptor	0.0063	0.0918	0.0918
Brugia malayi	hypothetical protein	0.0063	0.0918	0.0686
Plasmodium vivax	vivapain-2	0.01	0.1839	1
Echinococcus granulosus	G protein coupled receptor 139	0.0063	0.0918	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.1839	0.5274
Brugia malayi	Cathepsin L-like precursor	0.01	0.1839	0.1631
Echinococcus multilocularis	allatostatin A receptor	0.0063	0.0918	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Brugia malayi	Cathepsin L-like cysteine proteinase	0.01	0.1839	0.1631
Echinococcus granulosus	neuropeptides capa receptor	0.0063	0.0918	0.0686
Trypanosoma cruzi	cysteine peptidase, putative	0.01	0.1839	0.1631
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0063	0.0918	0.0686
Schistosoma mansoni	amine GPCR	0.0063	0.0918	0.0686
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0063	0.0918	0.0808
Brugia malayi	ORL1-like opioid receptor	0.0063	0.0918	0.0686
Onchocerca volvulus		0.0063	0.0918	0.499
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Echinococcus multilocularis	cathepsin L	0.0036	0.0249	0.013
Brugia malayi	Dopamine receptor	0.0063	0.0918	0.0686
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0918	0.0686
Echinococcus multilocularis	sex peptide receptor	0.0063	0.0918	0.0808
Echinococcus multilocularis	cysteine protease	0.01	0.1839	0.174
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Echinococcus granulosus	sex peptide receptor	0.0063	0.0918	0.0686
Schistosoma mansoni	biogenic amine receptor	0.0063	0.0918	0.0686
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.1839	0.5274
Schistosoma mansoni	neuropeptide receptor	0.0063	0.0918	0.0686
Brugia malayi	putative neuropeptide receptor NPR1	0.0063	0.0918	0.0686
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0063	0.0918	0.0686
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.01	0.1839	0.5274
Schistosoma mansoni	cathepsin F (C01 family)	0.01	0.1839	0.1631
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0918	0.0686
Echinococcus multilocularis	orexin receptor type 2	0.0063	0.0918	0.0808
Schistosoma mansoni	cathepsin F (C01 family)	0.01	0.1839	0.1631
Onchocerca volvulus		0.01	0.1839	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.01	0.1839	1
Loa Loa (eye worm)	hypothetical protein	0.01	0.1839	0.1839
Schistosoma mansoni	amine GPCR	0.0063	0.0918	0.0686
Entamoeba histolytica	cysteine protease, putative	0.01	0.1839	1
Onchocerca volvulus		0.0063	0.0918	0.499
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.01	0.1839	0.5274
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.1839	0.5274
Brugia malayi	Cathepsin L-like precursor	0.01	0.1839	0.1631
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0918	0.0686
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0918	0.0808
Echinococcus multilocularis	neuropeptides capa receptor	0.0063	0.0918	0.0808
Brugia malayi	Cathepsin L-like precursor	0.01	0.1839	0.1631
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Onchocerca volvulus		0.0063	0.0918	0.499
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0063	0.0918	0.0808
Schistosoma mansoni	neuropeptide receptor	0.0063	0.0918	0.0686
Brugia malayi	Cathepsin L-like precursor	0.01	0.1839	0.1631
Echinococcus granulosus	g-protein coupled receptor	0.0063	0.0918	0.0686
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.01	0.1839	0.1839
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0249	0.0249
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0063	0.0918	0.0918
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0063	0.0918	0.0686
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0063	0.0918	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0918	0.0808
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0918	0.0808
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.01	0.1839	0.174
Giardia lamblia	Cathepsin B precursor	0.0157	0.3265	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.1839	0.5274
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.1839	0.5274
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.01	0.1839	0.5274
Loa Loa (eye worm)	calpain family protein 1	0.0042	0.0399	0.0399
Echinococcus granulosus	allatostatin A receptor	0.0063	0.0918	0.0686
Echinococcus multilocularis	cysteine protease	0.01	0.1839	0.174
Schistosoma mansoni	growth hormone secretagogue receptor	0.0063	0.0918	0.0686
Echinococcus granulosus	tm gpcr rhodopsin	0.0063	0.0918	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Loa Loa (eye worm)	calpain family protein 1	0.0031	0.012	0.012
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.01	0.1839	0.5274
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0063	0.0918	0.0686
Schistosoma mansoni	histamine h1 receptor	0.0063	0.0918	0.0686
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0428	1	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Echinococcus granulosus	g protein coupled receptor	0.0063	0.0918	0.0686
Brugia malayi	G-protein coupled receptor	0.0063	0.0918	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0031	0.012	0.012
Brugia malayi	sulfakinin receptor protein	0.0063	0.0918	0.0686
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.01	0.1839	0.5274
Brugia malayi	hypothetical protein	0.0063	0.0918	0.0686
Schistosoma mansoni	opsin-like receptor	0.0063	0.0918	0.0686
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0063	0.0918	0.0808
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0063	0.0918	0.0686
Brugia malayi	Cathepsin L-like precursor	0.01	0.1839	0.1631
Echinococcus multilocularis	calpain A	0.0044	0.0447	0.0331
Brugia malayi	G protein-coupled receptor	0.0063	0.0918	0.0686
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0063	0.0918	0.0808
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.01	0.1839	0.5274
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.1839	0.5274
Echinococcus granulosus	cathepsin l1	0.01	0.1839	0.1631
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Echinococcus granulosus	tm gpcr rhodopsin	0.0063	0.0918	0.0686
Loa Loa (eye worm)	G-protein coupled receptor	0.0063	0.0918	0.0918
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0918	0.0686
Schistosoma mansoni	amine GPCR	0.0063	0.0918	0.0686
Echinococcus multilocularis	neuropeptide Y receptor	0.0063	0.0918	0.0808
Schistosoma mansoni	neuropeptide f receptor 76f	0.0063	0.0918	0.0686
Brugia malayi	Dopamine receptor protein 2	0.0063	0.0918	0.0686
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0063	0.0918	0.0686
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0918	0.0808
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0063	0.0918	0.0686
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0063	0.0918	0.0686
Onchocerca volvulus		0.0063	0.0918	0.499
Echinococcus multilocularis	serotonin receptor	0.0063	0.0918	0.0808
Echinococcus granulosus	neuropeptide Y receptor	0.0063	0.0918	0.0686
Echinococcus multilocularis	neuropeptide Y receptor	0.0063	0.0918	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Brugia malayi	neuropeptide F receptor	0.0063	0.0918	0.0686
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.01	0.1839	0.5274
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0063	0.0918	0.0808
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0063	0.0918	0.0686
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0157	0.3265	1
Onchocerca volvulus		0.0063	0.0918	0.499
Onchocerca volvulus		0.0063	0.0918	0.499
Onchocerca volvulus		0.0063	0.0918	0.499
Onchocerca volvulus		0.01	0.1839	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.01	0.1839	0.5274
Brugia malayi	calpain family protein 1	0.0042	0.0399	0.0154
Echinococcus granulosus	neuropeptide receptor	0.0063	0.0918	0.0686
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0918	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0249	0.0249
Brugia malayi	Melatonin receptor type 1A	0.0063	0.0918	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0249	0.0249
Echinococcus granulosus	biogenic amine 5HT receptor	0.0063	0.0918	0.0686
Loa Loa (eye worm)	hypothetical protein	0.01	0.1839	0.1839
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0063	0.0918	0.0686
Echinococcus granulosus	hypothetical protein	0.0063	0.0918	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0063	0.0918	0.0686
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0918	0.0686
Onchocerca volvulus		0.0063	0.0918	0.499
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0063	0.0918	0.0686
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0063	0.0918	0.0686
Loa Loa (eye worm)	hypothetical protein	0.01	0.1839	0.1839
Onchocerca volvulus		0.01	0.1839	1
Echinococcus granulosus	somatostatin receptor	0.0063	0.0918	0.0686
Giardia lamblia	Cathepsin B precursor	0.0157	0.3265	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.01	0.1839	0.5274
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.01	0.1839	0.5274
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.01	0.1839	0.5274
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.0918	0.0686
Schistosoma mansoni	opsin-like receptor	0.0063	0.0918	0.0686
Schistosoma mansoni	hypothetical protein	0.0063	0.0918	0.0686
Trypanosoma cruzi	cysteine peptidase, putative	0.01	0.1839	0.1631
Echinococcus multilocularis	fmrfamide receptor	0.0063	0.0918	0.0808
Entamoeba histolytica	cysteine proteinase, putative	0.01	0.1839	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0042	0.0399	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0044	0.0447	0.0331
Loa Loa (eye worm)	melatonin receptor type 1A	0.0063	0.0918	0.0918
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0399	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Brugia malayi	hypothetical protein	0.0063	0.0918	0.0686
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0063	0.0918	0.0808
Loa Loa (eye worm)	neuropeptide F receptor	0.0063	0.0918	0.0918
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Loa Loa (eye worm)	hypothetical protein	0.01	0.1839	0.1839
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0157	0.3265	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0063	0.0918	0.0918
Echinococcus granulosus	g protein coupled receptor	0.0063	0.0918	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Echinococcus multilocularis	g-protein coupled receptor	0.0063	0.0918	0.0808
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.01	0.1839	0.5274
Brugia malayi	AKH receptor	0.0063	0.0918	0.0686
Onchocerca volvulus		0.01	0.1839	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.1839	0.5274
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0918	0.0686
Loa Loa (eye worm)	cysteine protease	0.01	0.1839	0.1839
Loa Loa (eye worm)	fibroinase	0.01	0.1839	0.1839
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.0918	0.0686
Toxoplasma gondii	cathepsin B	0.0157	0.3265	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.01	0.1839	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0249	0.0249
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0428	1	1
Schistosoma mansoni	biogenic amine receptor	0.0063	0.0918	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0428	1	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0063	0.0918	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Onchocerca volvulus	Cathepsin F homolog	0.01	0.1839	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Onchocerca volvulus		0.0063	0.0918	0.499
Echinococcus granulosus	biogenic amine 5HT receptor	0.0063	0.0918	0.0686
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.1839	0.5274
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.0918	0.0686
Onchocerca volvulus		0.01	0.1839	1
Schistosoma mansoni	hypothetical protein	0.0063	0.0918	0.0686
Echinococcus granulosus	cathepsin l cysteine peptidase	0.01	0.1839	0.1631
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0063	0.0918	0.0808
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0063	0.0918	0.0808
Echinococcus multilocularis	g protein coupled receptor	0.0063	0.0918	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Echinococcus multilocularis	g protein coupled receptor	0.0063	0.0918	0.0808
Brugia malayi	larval opioid receptor	0.0063	0.0918	0.0686
Echinococcus granulosus	7tm_1 domain containing protein	0.0063	0.0918	0.0686
Loa Loa (eye worm)	ctsf protein	0.01	0.1839	0.1839
Schistosoma mansoni	neuropeptide receptor	0.0063	0.0918	0.0686
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.01	0.1839	0.5274
Schistosoma mansoni	neuropeptide F-like receptor	0.0063	0.0918	0.0686
Trypanosoma cruzi	cruzipain precursor, putative	0.01	0.1839	0.1631
Brugia malayi	hypothetical protein	0.0063	0.0918	0.0686
Schistosoma mansoni	amine GPCR	0.0063	0.0918	0.0686
Onchocerca volvulus	Cathepsin L homolog	0.0036	0.0249	0.1352
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.01	0.1839	0.174
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0249	0.0249
Schistosoma mansoni	biogenic amine receptor	0.0063	0.0918	0.0686
Brugia malayi	hypothetical protein	0.0063	0.0918	0.0686
Schistosoma mansoni	adenoreceptor	0.0063	0.0918	0.0686
Brugia malayi	neuropeptide F receptor	0.0063	0.0918	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Echinococcus granulosus	7TM GPCR rhodopsin	0.0063	0.0918	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.01	0.1839	0.1839
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0063	0.0918	0.0686
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0063	0.0918	0.0686
Echinococcus multilocularis	cathepsin L	0.0036	0.0249	0.013
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0063	0.0918	0.499
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Brugia malayi	cathepsin L-like precursor	0.01	0.1839	0.1631
Echinococcus granulosus	neuropeptide receptor	0.0063	0.0918	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0918	0.0918
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0063	0.0918	0.0808
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.0918	0.0686
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0044	0.0447	0.0203
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0063	0.0918	0.0686
Echinococcus multilocularis	neuropeptide s receptor	0.0063	0.0918	0.0808
Echinococcus multilocularis	g protein coupled receptor	0.0063	0.0918	0.0808
Echinococcus granulosus	g protein coupled receptor	0.0063	0.0918	0.0686
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.01	0.1839	0.5274
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0063	0.0918	0.0808
Loa Loa (eye worm)	cathepsin B	0.0157	0.3265	0.3265
Echinococcus multilocularis	serotonin receptor	0.0063	0.0918	0.0808
Loa Loa (eye worm)	G-protein coupled receptor	0.0063	0.0918	0.0918
Brugia malayi	hypothetical protein	0.0063	0.0918	0.0686
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.1839	0.5274
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0063	0.0918	0.0918
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0063	0.0918	0.0808
Brugia malayi	Serotonin receptor	0.0063	0.0918	0.0686
Echinococcus granulosus	neuropeptide s receptor	0.0063	0.0918	0.0686
Schistosoma mansoni	amine GPCR	0.0063	0.0918	0.0686
Onchocerca volvulus		0.01	0.1839	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0063	0.0918	0.0686
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.01	0.1839	0.5274
Echinococcus multilocularis	cathepsin L cysteine protease	0.01	0.1839	0.174

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 56.3 %	Antiparkinsonian activity against haloperidol-induced catalepsy in Mus musculus Swiss albino (mouse) assessed reduction in catalepsy at 100 mg/kg, ip administered 30 min prior to haloperidol injection measured after 30 to 180 min	ChEMBL.	No reference
TIME (functional)	= 77 s	Antiparkinsonian activity against haloperidol-induced catalepsy in Mus musculus Swiss albino (mouse) assessed as decrease in mean descent time at 100 mg/kg, ip administered 30 min prior to haloperidol injection measured after 30 min	ChEMBL.	No reference
TIME (functional)	= 89 s	Antiparkinsonian activity against haloperidol-induced catalepsy in Mus musculus Swiss albino (mouse) assessed as decrease in mean descent time at 100 mg/kg, ip administered 30 min prior to haloperidol injection measured after 60 min	ChEMBL.	No reference
TIME (functional)	= 114 s	Antiparkinsonian activity against haloperidol-induced catalepsy in Mus musculus Swiss albino (mouse) assessed as decrease in mean descent time at 100 mg/kg, ip administered 30 min prior to haloperidol injection measured after 90 min	ChEMBL.	No reference
TIME (functional)	= 118 s	Antiparkinsonian activity against haloperidol-induced catalepsy in Mus musculus Swiss albino (mouse) assessed as decrease in mean descent time at 100 mg/kg, ip administered 30 min prior to haloperidol injection measured after 120 min	ChEMBL.	No reference
TIME (functional)	= 129 s	Antiparkinsonian activity against haloperidol-induced catalepsy in Mus musculus Swiss albino (mouse) assessed as decrease in mean descent time at 100 mg/kg, ip administered 30 min prior to haloperidol injection measured after 150 min	ChEMBL.	No reference
TIME (functional)	= 173 s	Antiparkinsonian activity against haloperidol-induced catalepsy in Mus musculus Swiss albino (mouse) assessed as decrease in mean descent time at 100 mg/kg, ip administered 30 min prior to haloperidol injection measured after 180 min	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2234688

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1809381