Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0511 | 0.1502 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.031 | 0.0603 | 0.4016 |
Entamoeba histolytica | protein kinase, putative | 0.027 | 0.0421 | 1 |
Echinococcus multilocularis | aurora kinase A | 0.027 | 0.0421 | 0.2804 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.031 | 0.0603 | 0.4016 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.027 | 0.0421 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.031 | 0.0603 | 0.4016 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.031 | 0.0603 | 0.4016 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.031 | 0.0603 | 0.4016 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.027 | 0.0421 | 0.2804 |
Entamoeba histolytica | protein kinase , putative | 0.027 | 0.0421 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.027 | 0.0421 | 0.0448 |
Entamoeba histolytica | protein kinase, putative | 0.027 | 0.0421 | 1 |
Schistosoma mansoni | protein kinase | 0.027 | 0.0421 | 0.2804 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.031 | 0.0603 | 0.4016 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.027 | 0.0421 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.027 | 0.0421 | 0.0448 |
Brugia malayi | serine/threonine kinase 12 | 0.027 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | AUR protein kinase | 0.027 | 0.0421 | 0.0448 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0511 | 0.1502 | 1 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.027 | 0.0421 | 1 |
Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.031 | 0.0603 | 0.4016 |
Trypanosoma cruzi | aurora B kinase, putative | 0.027 | 0.0421 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2102 | 0.8612 | 0.9165 |
Trichomonas vaginalis | AGC family protein kinase | 0.027 | 0.0421 | 1 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.031 | 0.0603 | 0.4016 |
Trichomonas vaginalis | AGC family protein kinase | 0.027 | 0.0421 | 1 |
Echinococcus granulosus | aurora kinase A | 0.027 | 0.0421 | 0.2804 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.031 | 0.0603 | 0.0642 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.031 | 0.0603 | 0.4016 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.027 | 0.0421 | 0.2804 |
Loa Loa (eye worm) | hypothetical protein | 0.2278 | 0.9397 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.027 | 0.0421 | 0.2804 |
Toxoplasma gondii | aurora kinase | 0.027 | 0.0421 | 0.5 |
Brugia malayi | serine/threonine protein kinase 6 | 0.027 | 0.0421 | 0.0421 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.031 | 0.0603 | 0.4016 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.031 | 0.0603 | 0.4016 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.031 | 0.0603 | 0.4016 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.027 | 0.0421 | 0.0421 |
Trichomonas vaginalis | AGC family protein kinase | 0.027 | 0.0421 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.031 | 0.0603 | 0.4016 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.027 | 0.0421 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2102 | 0.8612 | 0.9165 |
Trypanosoma brucei | aurora B kinase | 0.027 | 0.0421 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0511 | 0.1502 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2102 | 0.8612 | 0.9165 |
Onchocerca volvulus | 0.2237 | 0.9216 | 1 | |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0511 | 0.1502 | 0.1598 |
Entamoeba histolytica | protein kinase domain containing protein | 0.027 | 0.0421 | 1 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0511 | 0.1502 | 0.1502 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.031 | 0.0603 | 0.4016 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.031 | 0.0603 | 0.4016 |
Giardia lamblia | Aurora kinase | 0.027 | 0.0421 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.027 | 0.0421 | 1 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.027 | 0.0421 | 0.5 |
Leishmania major | protein kinase, putative | 0.027 | 0.0421 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.031 | 0.0603 | 0.4016 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 8.02 uM | Anti-inflammatory activity in Mus musculus (mouse) RAW264.7 cells assessed as inhibition of IFN-gamma/LPS-induced nitric oxide production after 17 to 20 hr by Griess assay | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.