Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0365 | 0.3973 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1344 | 0.0987 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0461 | 0.5233 | 0.4967 |
Entamoeba histolytica | glycogen debranching enzyme, putative | 0.0128 | 0.0864 | 1 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0823 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0103 | 0.0528 | 0.1246 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0103 | 0.0528 | 0.1246 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0237 | 0.2295 | 0.1865 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0103 | 0.0528 | 0.1246 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0823 | 1 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0143 | 0.1063 | 0.2033 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0461 | 0.5233 | 0.4967 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0303 | 0.3158 | 1 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0128 | 0.0864 | 0.211 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0103 | 0.0528 | 0.1246 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0303 | 0.3158 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0159 | 0.1276 | 0.5 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0128 | 0.0864 | 0.211 |
Schistosoma mansoni | alpha-glucosidase | 0.041 | 0.457 | 0.4346 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.2295 | 0.2295 |
Echinococcus granulosus | glycogen debranching enzyme | 0.0128 | 0.0864 | 0.0354 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0461 | 0.5233 | 0.4967 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0823 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0303 | 0.3158 | 1 |
Giardia lamblia | 4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase | 0.0128 | 0.0864 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0303 | 0.3158 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0103 | 0.0528 | 0.1246 |
Echinococcus multilocularis | glycogen debranching enzyme | 0.0128 | 0.0864 | 0.0354 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0143 | 0.1063 | 0.2033 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0237 | 0.2295 | 0.1865 |
Echinococcus granulosus | fucosidase alpha L 1 tissue | 0.0823 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.041 | 0.457 | 0.4346 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0361 | 0.3927 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0103 | 0.0528 | 0.1246 |
Toxoplasma gondii | Amylo-alpha-1,6-glucosidase | 0.0128 | 0.0864 | 1 |
Brugia malayi | Amylo-alpha-1,6-glucosidase family protein | 0.0128 | 0.0864 | 0.0354 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0103 | 0.0528 | 0.0528 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0103 | 0.0528 | 0.1246 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0461 | 0.5233 | 0.4967 |
Brugia malayi | hypothetical protein | 0.0237 | 0.2295 | 0.1865 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0103 | 0.0528 | 0.1246 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0461 | 0.5233 | 0.5233 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0103 | 0.0528 | 0.1246 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0143 | 0.1063 | 0.2033 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0361 | 0.3927 | 1 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0823 | 1 | 1 |
Schistosoma mansoni | alpha glucosidase | 0.0103 | 0.0528 | 0.0137 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.7 uM | Inhibition of HIV replication in H9 cells. | ChEMBL. | 7650672 |
IC50 (functional) | = 31.7 uM | The compound was tested for inhibition of HIV-1 replication in SW480 cells using HIV tat assay | ChEMBL. | 7650672 |
IC50 (functional) | = 31.7 uM | The compound was tested for inhibition of HIV-1 replication in SW480 cells using HIV tat assay | ChEMBL. | 7650672 |
Therapeutic index (ADMET) | = 2.3 | Therapeutic index, measured by whole cell assay. | ChEMBL. | 7650672 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.