Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0444 | 0.0444 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1466 | 1 | 0.5 |
Schistosoma mansoni | vesicular amine transporter | 0.0084 | 0.0249 | 0.0249 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1466 | 1 | 0.5 |
Echinococcus granulosus | twitchin | 0.0119 | 0.0495 | 0.0495 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0084 | 0.0249 | 0.0249 |
Schistosoma mansoni | tyrosine kinase | 0.0057 | 0.0054 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0249 | 0.0249 |
Echinococcus multilocularis | Immunoglobulin | 0.0084 | 0.0249 | 0.0249 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1466 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1466 | 1 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0112 | 0.0444 | 0.0444 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0249 | 0.0249 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0596 | 0.0596 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0062 | 0.0094 | 0.0094 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1466 | 1 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.1466 | 1 | 0.5 |
Echinococcus granulosus | neuroglian | 0.0106 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1466 | 1 | 1 |
Echinococcus granulosus | defective proboscis extension response | 0.0084 | 0.0249 | 0.0249 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1466 | 1 | 0.5 |
Echinococcus multilocularis | roundabout 2 | 0.0134 | 0.0596 | 0.0596 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1466 | 1 | 0.5 |
Echinococcus granulosus | Immunoglobulin | 0.0084 | 0.0249 | 0.0249 |
Onchocerca volvulus | Basement membrane proteoglycan homolog | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0596 | 0.0596 |
Schistosoma mansoni | nephrin | 0.0106 | 0.0402 | 0.0402 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1466 | 1 | 0.5 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.012 | 0.0498 | 0.0498 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0249 | 0.0249 |
Echinococcus multilocularis | Immunoglobulin | 0.0084 | 0.0249 | 0.0249 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1466 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1466 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1466 | 1 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0134 | 0.0596 | 0.0596 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0112 | 0.0444 | 0.0444 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.012 | 0.0498 | 0.0498 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1466 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1466 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1466 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1466 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0249 | 0.0249 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1466 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0249 | 0.0249 |
Echinococcus multilocularis | neuroglian | 0.0106 | 0.0402 | 0.0402 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0084 | 0.0249 | 0.0249 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1466 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0249 | 0.0249 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0084 | 0.0249 | 0.0249 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1466 | 1 | 0.5 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0084 | 0.0249 | 0.0249 |
Brugia malayi | hypothetical protein | 0.0084 | 0.0249 | 0.0249 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0084 | 0.0249 | 0.0249 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of ubiquitin displacement on His6-tagged E2 enzyme from His6-tagged UBA1 (unknown origin) at 10 uM after 1.5 hr by SDS-PAGE analysis | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.