Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Zea mays | Glutamine synthetase, chloroplastic | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | glutamine synthetase, type I, putative | Glutamine synthetase, chloroplastic | 423 aa | 342 aa | 22.8 % |
Neospora caninum | Glutamine synthetase (EC 6.3.1.2), related | Glutamine synthetase, chloroplastic | 423 aa | 346 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0288 | 1 | 1 | |
Leishmania major | carbonic anhydrase family protein, putative | 0.0222 | 0.6691 | 0.5608 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0146 | 0.2866 | 0.0531 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.037 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0146 | 0.2866 | 0.0946 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0288 | 1 | 1 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0096 | 0.037 | 0.1974 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0096 | 0.037 | 0.0553 |
Trypanosoma brucei | Prostaglandin E synthase | 0.0288 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0146 | 0.2866 | 0.0531 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0146 | 0.2866 | 0.0946 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0222 | 0.6691 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0126 | 0.1875 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0146 | 0.2866 | 0.0531 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.037 | 0.5 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0222 | 0.6691 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0146 | 0.2866 | 1 |
Plasmodium vivax | glutamine synthetase, putative | 0.0089 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0222 | 0.6691 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0146 | 0.2866 | 0.2866 |
Plasmodium falciparum | glutamine synthetase, putative | 0.0089 | 0 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0146 | 0.2866 | 0.2866 |
Leishmania major | carbonic anhydrase-like protein | 0.0146 | 0.2866 | 0.0531 |
Toxoplasma gondii | prostaglandin-E synthase | 0.0288 | 1 | 1 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.0288 | 1 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0222 | 0.6691 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0146 | 0.2866 | 1 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0288 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | Growth inhibition of Arabidopsis thaliana suspension cultured cells assessed as reduction in dry weight increase measured 8 days after compound incubation | ChEMBL. | 18399639 | |
IC50 (binding) | = 3.991 | Inhibition of Arabidopsis thaliana P5C assessed as reduction in NADH oxidation incubated at 35 degC up to 10 min | ChEMBL. | 18399639 |
IC50 (binding) | = 4.893 | Inhibition of Zea mays cv. Jeff (maize) leaf glutamine synthetase using L-glutamate as substrate assessed as inorganic phosphate production after 20 min by malachite green assay relative to control | ChEMBL. | 19697446 |
IC50 (binding) | = 0.102 mM | Inhibition of Arabidopsis thaliana P5C assessed as reduction in NADH oxidation incubated at 35 degC up to 10 min | ChEMBL. | 18399639 |
IC50 (binding) | = 12.8 uM | Inhibition of Zea mays cv. Jeff (maize) leaf glutamine synthetase using L-glutamate as substrate assessed as inorganic phosphate production after 20 min by malachite green assay relative to control | ChEMBL. | 19697446 |
Inhibition (binding) | = 84.9 % | Inhibition of Zea mays cv. Jeff (maize) leaf glutamine synthetase using L-glutamate as substrate assessed as inorganic phosphate production at 1 mM after 20 min by malachite green assay relative to control | ChEMBL. | 19697446 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.