TDR Targets

Basic information

Technical information

TDR Targets ID: 1814559
Name: 2-tert-butyl-4-chloro-5-[[5-(2-chlorophenyl)- 1,3,4-oxadiazol-2-yl]methoxy]pyridazin-3-one
MW: 395.24 | Formula: C17H16Cl2N4O3
H donors: 0 H acceptors: 3 LogP: 3.12 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccccc1c1nnc(o1)COc1cnn(c(=O)c1Cl)C(C)(C)C
InChi: 1S/C17H16Cl2N4O3/c1-17(2,3)23-16(24)14(19)12(8-20-23)25-9-13-21-22-15(26-13)10-6-4-5-7-11(10)18/h4-8H,9H2,1-3H3
InChiKey: DMENOPFLFUTSKQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-tert-butyl-4-chloro-5-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]methoxy]-3-pyridazinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.003	0.0497	0.0347
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0218	0.0122
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0218	0.0414
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0238	0.0451
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0022	0.0238	0.0177
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0218	0.0414
Leishmania major	DNA polymerase eta, putative	0.0022	0.0218	0.0122
Brugia malayi	Importin beta-1 subunit	0.003	0.0497	0.0734
Plasmodium vivax	stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative	0.0164	0.4807	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0218	0.0414
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0218	0.0414
Echinococcus granulosus	importin subunit beta 1	0.003	0.0497	0.0347
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0238	0.0084
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0238	0.2408
Echinococcus multilocularis	dna polymerase kappa	0.0022	0.0218	0.0064
Schistosoma mansoni	importin beta-1	0.003	0.0497	0.0347
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0218	0.0135
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0156	0.5
Loa Loa (eye worm)	acyl-CoA desaturase	0.0164	0.4807	0.4724
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0238	0.0084
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0022	0.0218	0.0064
Leishmania major	stearic acid desaturase, putative	0.0178	0.5273	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0238	0.0161
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0022	0.0218	0.0064
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0238	0.0084
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0311	0.0305
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0218	0.0414
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0022	0.0218	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0218	0.0414
Trypanosoma cruzi	fatty acid desaturase, putative	0.0164	0.4807	0.9089
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0083	0.22	0.2076
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0218	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0218	0.0064
Trypanosoma cruzi	fatty acid desaturase, putative	0.0164	0.4807	0.9089
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0083	0.22	0.2076
Trichomonas vaginalis	DNA polymerase eta, putative	0.0022	0.0218	0.4015
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0218	0.0414
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0238	0.0161
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.0218	1
Entamoeba histolytica	Ran family GTPase	0.0022	0.0238	0.5279
Entamoeba histolytica	hypothetical protein	0.0025	0.0311	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0083	0.22	0.2076
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0497	1
Leishmania major	GTP-binding protein, putative	0.0022	0.0238	0.0161
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0083	0.22	0.2076
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0022	0.0238	0.0177
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0218	0.0414
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0311	1
Schistosoma mansoni	hypothetical protein	0.0324	1	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0022	0.0218	0.0122
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0022	0.0218	0.4015
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0083	0.22	0.2076
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0218	0.0122
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0238	0.0177
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0311	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0218	0.0135
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0083	0.22	0.2076
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0156	0.5
Trypanosoma brucei	DNA polymerase eta, putative	0.0022	0.0218	0.0414
Brugia malayi	acyl-CoA desaturase	0.0164	0.4807	1
Plasmodium vivax	importin-beta 2, putative	0.003	0.0497	0.0734
Echinococcus granulosus	dna polymerase kappa	0.0022	0.0218	0.0064
Giardia lamblia	DINP protein human, muc B family	0.0022	0.0218	0.7605
Schistosoma mansoni	ran	0.0022	0.0238	0.0084
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0022	0.0238	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0083	0.22	0.4395
Trypanosoma cruzi	fatty acid desaturase, putative	0.0178	0.5273	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0083	0.22	0.2076
Schistosoma mansoni	ran	0.0022	0.0238	0.0084
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0218	0.0414
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0218	0.0122
Trypanosoma brucei	unspecified product	0.0022	0.0218	0.0414
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0218	0.0122
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0497	0.0943
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0022	0.0218	0.0064
Echinococcus multilocularis	snurportin 1	0.0324	1	1
Trypanosoma brucei	fatty acid desaturase, putative	0.0178	0.5273	1
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0022	0.0218	0.0064
Onchocerca volvulus		0.0178	0.5273	0.5
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0218	1
Brugia malayi	RNA, U transporter 1	0.0086	0.2308	0.4628
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0497	0.0943
Plasmodium falciparum	stearoyl-CoA desaturase	0.0164	0.4807	1
Onchocerca volvulus		0.0178	0.5273	0.5
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0156	0.0295
Trichomonas vaginalis	ran, putative	0.0022	0.0238	0.5279
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0311	1
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0218	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0022	0.0218	0.0064
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0218	0.0414
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0311	0.0305
Echinococcus granulosus	dna polymerase eta	0.0022	0.0218	0.0064
Leishmania major	fatty-acid desaturase, putative	0.0178	0.5273	1
Schistosoma mansoni	DNA polymerase eta	0.0022	0.0218	0.0064
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0218	0.0414
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0083	0.22	0.2076
Plasmodium falciparum	importin beta, putative	0.003	0.0497	0.0734
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0324	1	1
Leishmania major	DNA polymerase kappa, putative	0.0022	0.0218	0.0122
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0218	0.0414
Echinococcus multilocularis	dna polymerase eta	0.0022	0.0218	0.0064
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0022	0.0218	0.4015
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0022	0.0218	0.0122
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0497	0.0347

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2252548

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1814559