Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neuropeptide Y receptor Y2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Echinococcus granulosus | neuropeptide receptor | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Echinococcus multilocularis | neuropeptide receptor | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Schistosoma mansoni | neuropeptide receptor | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Echinococcus multilocularis | G protein coupled receptor 139 | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | neuropeptide Y receptor Y2 | 381 aa | 388 aa | 20.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0056 | 0.0325 | 0.0257 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.002 | 0.0069 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.002 | 0.0069 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.1201 | 0.8364 | 0.8352 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0056 | 0.0325 | 0.0257 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0325 | 0.0384 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.002 | 0.0069 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.002 | 0.0069 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.021 | 0.1403 | 0.1672 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0056 | 0.0325 | 0.5 |
Schistosoma mansoni | brg-1 associated factor | 0.0056 | 0.0325 | 0.0384 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0056 | 0.0325 | 0.0257 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0325 | 0.0384 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.002 | 0.0069 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0056 | 0.0325 | 0.0257 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0069 | 0.0078 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.002 | 0.0069 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.0056 | 0.0325 | 0.5 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0056 | 0.0325 | 0.0257 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.1201 | 0.8364 | 0.8352 |
Entamoeba histolytica | protein kinase, putative | 0.1201 | 0.8367 | 1 |
Leishmania major | hypothetical protein, conserved | 0.002 | 0.0069 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0056 | 0.0325 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0056 | 0.0325 | 1 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.002 | 0.0069 | 0.0078 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0188 | 0.125 | 0.1189 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.1403 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.002 | 0.0069 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0056 | 0.0325 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0325 | 0.0384 |
Entamoeba histolytica | protein kinase, putative | 0.1201 | 0.8367 | 1 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0069 | 0.0078 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1201 | 0.8367 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.002 | 0.0069 | 1 |
Echinococcus granulosus | serine:threonine protein kinase Chk2 | 0.1201 | 0.8367 | 0.8356 |
Echinococcus multilocularis | neuropeptide receptor | 0.0188 | 0.125 | 0.1189 |
Schistosoma mansoni | RNA binding protein | 0.002 | 0.0069 | 0.0078 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0056 | 0.0325 | 0.0257 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0056 | 0.0325 | 1 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0056 | 0.0325 | 1 |
Schistosoma mansoni | neuropeptide receptor | 0.0188 | 0.125 | 0.149 |
Trypanosoma brucei | hypothetical protein, conserved | 0.002 | 0.0069 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.002 | 0.0069 | 1 |
Onchocerca volvulus | 0.0056 | 0.0325 | 0.1915 | |
Brugia malayi | brahma associated protein 60 kDa | 0.0056 | 0.0325 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.1433 | 1 | 1 |
Schistosoma mansoni | fusion | 0.002 | 0.0069 | 0.0078 |
Trypanosoma brucei | hypothetical protein, conserved | 0.002 | 0.0069 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0056 | 0.0325 | 0.5 |
Loa Loa (eye worm) | brahma associated protein | 0.0056 | 0.0325 | 0.1915 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0056 | 0.0325 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.002 | 0.0069 | 1 |
Giardia lamblia | Kinase, NEK | 0.0011 | 0.0004 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0056 | 0.0325 | 1 |
Giardia lamblia | Kinase | 0.0011 | 0.0004 | 0.5 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0056 | 0.0325 | 0.1915 |
Leishmania major | hypothetical protein, conserved | 0.002 | 0.0069 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0056 | 0.0325 | 0.5 |
Onchocerca volvulus | 0.021 | 0.1403 | 1 | |
Leishmania major | hypothetical protein, conserved | 0.002 | 0.0069 | 1 |
Giardia lamblia | Kinase, NEK | 0.0011 | 0.0004 | 0.5 |
Echinococcus granulosus | neuropeptide receptor | 0.0188 | 0.125 | 0.1189 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.002 | 0.0069 | 1 |
Leishmania major | hypothetical protein, conserved | 0.002 | 0.0069 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.002 | 0.0069 | 1 |
Leishmania major | hypothetical protein, conserved | 0.002 | 0.0069 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.1201 | 0.8367 | 0.8356 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.6 uM | Displacement of [125I]-PYY from human NPYY2 receptor | ChEMBL. | 24365162 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.