TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 262.306 | Formula: C17H14N2O
H donors: 1 H acceptors: 3 LogP: 3.48 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)c1cc(O)nnc1c1ccccc1
InChi: 1S/C17H14N2O/c1-12-7-9-13(10-8-12)15-11-16(20)18-19-17(15)14-5-3-2-4-6-14/h2-11H,1H3,(H,18,20)
InChiKey: QNCJRMLPFCTQHE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0031	0.8889	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0849	0.0692
Giardia lamblia	Aldose reductase	0.0031	0.8889	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0849	0.0692
Entamoeba histolytica	P-glyco protein 6, putative	0.001	0.0849	0.0692
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.8889	1
Trypanosoma cruzi	ferric reductase transmembrane protein, putative	0.0034	1	1
Echinococcus granulosus	ATP binding cassette sub family G	0.001	0.0578	0.0378
Toxoplasma gondii	microneme protein MIC17C	0.0014	0.2272	0.2339
Onchocerca volvulus		0.0031	0.8889	0.886
Loa Loa (eye worm)	oxidoreductase	0.0031	0.8889	0.8889
Schistosoma mansoni	multidrug resistance protein	0.001	0.0849	0.0955
Echinococcus multilocularis	aldehyde reductase	0.0022	0.5367	0.5922
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.001	0.0578	0.0378
Plasmodium falciparum	multidrug resistance protein 1	0.001	0.0849	0.1183
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.8889	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.8889	1
Trypanosoma brucei	ferric reductase transmembrane protein, putative	0.0034	1	1
Trichomonas vaginalis	taga, putative	0.001	0.0849	0.0692
Loa Loa (eye worm)	hypothetical protein	0.0014	0.2272	0.2272
Entamoeba histolytica	hypothetical protein	0.001	0.0519	0.031
Onchocerca volvulus		0.001	0.0849	0.0613
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0849	0.0692
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0849	0.0692
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0022	0.53	1
Onchocerca volvulus		0.0014	0.2272	0.2072
Trypanosoma brucei	ATP-binding cassette protein, putative	0.001	0.0578	0.0335
Entamoeba histolytica	P-glycoprotein-2	0.001	0.0849	0.0692
Loa Loa (eye worm)	hypothetical protein	0.0022	0.53	0.53
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0849	0.0692
Echinococcus granulosus	aldehyde reductase	0.0022	0.5367	0.5922
Schistosoma mansoni	aldo-keto reductase	0.0031	0.8889	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.8889	1
Plasmodium vivax	ABC transporter G family member 2, putative	0.001	0.0578	0.0647
Plasmodium falciparum	ABC transporter G family member 2	0.001	0.0578	0.0647
Schistosoma mansoni	smdr2	0.001	0.0849	0.0955
Echinococcus granulosus	tissue type plasminogen activator	0.0022	0.53	0.5845
Brugia malayi	PAN domain containing protein	0.0014	0.2272	0.2272
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.53	0.5179
Loa Loa (eye worm)	PAN domain-containing protein	0.0014	0.2272	0.2272
Toxoplasma gondii	ATP-binding cassette G family transporter ABCG84	0.001	0.0578	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0014	0.2272	0.2272
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0849	0.0692
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.8889	1
Plasmodium falciparum	cysteine repeat modular protein 1	0.0022	0.53	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0031	0.8889	0.8889
Echinococcus granulosus	aldo keto reductase	0.0031	0.8889	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.8889	1
Toxoplasma gondii	PAN domain-containing protein	0.0014	0.2272	0.2339
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.8889	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.8889	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0031	0.8889	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.8889	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.8889	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.8889	1
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.001	0.0849	0.0849
Brugia malayi	Protein kinase domain containing protein	0.0022	0.53	0.53
Onchocerca volvulus		0.0014	0.2272	0.2072
Echinococcus granulosus	ATP binding cassette sub family G	0.001	0.0578	0.0378
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0849	0.0692
Onchocerca volvulus		0.0014	0.2272	0.2072
Schistosoma mansoni	potassium channel beta	0.0009	0.0251	0.0283
Entamoeba histolytica	aldose reductase, putative	0.0031	0.8889	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0849	0.0692
Echinococcus multilocularis	multidrug resistance protein 1	0.001	0.0849	0.0692
Trypanosoma cruzi	ATP-binding cassette protein, putative	0.001	0.0578	0.0335
Brugia malayi	PAN domain containing protein	0.0014	0.2272	0.2272
Echinococcus multilocularis	aldo keto reductase	0.0031	0.8889	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0849	0.0692
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.8889	1
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.001	0.0849	0.0692
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.001	0.076	0.0589
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.8889	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.8889	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.8889	1
Onchocerca volvulus		0.0014	0.2272	0.2072
Onchocerca volvulus		0.0031	0.8889	0.886
Onchocerca volvulus		0.0031	0.8889	0.886
Trypanosoma cruzi	aldo-keto reductase	0.0031	0.8889	0.886
Giardia lamblia	Aldose reductase	0.0031	0.8889	1
Leishmania major	prostaglandin f synthase, putative	0.0031	0.8889	0.886
Loa Loa (eye worm)	TK/ROR protein kinase	0.0022	0.53	0.53
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0031	0.8889	0.886
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0849	0.0692
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0849	0.0692
Echinococcus granulosus	multidrug resistance protein 1	0.001	0.0849	0.0692
Loa Loa (eye worm)	PAN domain-containing protein	0.0014	0.2272	0.2272
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.8889	1
Echinococcus multilocularis	aldo keto reductase	0.0031	0.8889	1
Trypanosoma cruzi	ferric reductase transmembrane protein, putative	0.0034	1	1
Loa Loa (eye worm)	oxidoreductase	0.0031	0.8889	0.8889
Loa Loa (eye worm)	hypothetical protein	0.0014	0.2272	0.2272
Toxoplasma gondii	PAN domain-containing protein	0.0014	0.2272	0.2339
Loa Loa (eye worm)	hypothetical protein	0.0014	0.2272	0.2272
Loa Loa (eye worm)	hypothetical protein	0.0014	0.2272	0.2272
Toxoplasma gondii	microneme protein MIC17A	0.0014	0.2272	0.2339
Mycobacterium leprae	Conserved hypothetical protein	0.0022	0.5367	0.5922
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.001	0.0578	0.0378
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0849	0.0692
Echinococcus multilocularis	aldo keto reductase	0.0031	0.8889	1
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.001	0.0578	0.0378
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0031	0.8889	0.8889
Onchocerca volvulus		0.0014	0.2272	0.2072
Entamoeba histolytica	P-glycoprotein-5	0.001	0.0849	0.0692
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0849	0.0692
Entamoeba histolytica	P-glycoprotein-1	0.001	0.0849	0.0692
Leishmania major	ATP-binding cassette protein subfamily G, member 6, putative	0.001	0.0578	0.0335
Echinococcus multilocularis	ATP binding cassette sub family G	0.001	0.0578	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0014	0.2272	0.2272
Trypanosoma brucei	ABC transporter, putative	0.001	0.0578	0.0335
Onchocerca volvulus		0.0014	0.2272	0.2072
Echinococcus multilocularis	ATP binding cassette sub family G	0.001	0.0578	0.0378
Echinococcus granulosus	hypothetical protein	0.0031	0.8889	1
Brugia malayi	multidrug resistance protein 3	0.001	0.0849	0.0849
Entamoeba histolytica	aldose reductase, putative	0.0031	0.8889	1
Onchocerca volvulus		0.0031	0.8889	0.886
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.8889	1
Toxoplasma gondii	PAN domain-containing protein	0.0014	0.2272	0.2339
Schistosoma mansoni	multidrug resistance protein	0.001	0.0849	0.0955
Loa Loa (eye worm)	hypothetical protein	0.001	0.0849	0.0849
Echinococcus multilocularis	tissue type plasminogen activator	0.0022	0.53	0.5845
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.8889	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.8889	0.8889
Treponema pallidum	hypothetical protein	0.001	0.0519	0.5
Leishmania major	aldo-keto reductase-like protein	0.0031	0.8889	0.886
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0031	0.8889	0.886
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0849	0.0692
Toxoplasma gondii	microneme protein MIC4	0.0014	0.2272	0.2339
Schistosoma mansoni	aldo-keto reductase	0.0031	0.8889	1
Trypanosoma brucei	prostaglandin f synthase	0.0031	0.8889	0.886
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.8889	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0849	0.0692
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0014	0.2272	0.2339
Mycobacterium ulcerans	oxidoreductase	0.0031	0.8889	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0031	0.8889	1
Toxoplasma gondii	subtilisin SUB12	0.0014	0.2272	0.2339
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.001	0.0849	0.0692
Loa Loa (eye worm)	multidrug resistance protein 3	0.001	0.0849	0.0849
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0849	0.0692
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.001	0.0849	0.5
Echinococcus granulosus	ATP binding cassette sub family G	0.001	0.0578	0.0378
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0849	0.0692
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0031	0.8889	0.8889
Onchocerca volvulus		0.0022	0.53	0.5179
Brugia malayi	PAN domain containing protein	0.0014	0.2272	0.2272
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0031	0.8889	1
Echinococcus multilocularis	ATP binding cassette sub family G	0.001	0.0578	0.0378
Schistosoma mansoni	ATP-binding cassette sub-family g2 (white protein) (abcg2)	0.001	0.0578	0.0651
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.001	0.0849	0.0692
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0849	0.0692
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.8889	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.076	0.076
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0849	0.0692
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0009	0.0251	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0014	0.2272	0.2272
Trypanosoma cruzi	ABC transporter, putative	0.001	0.0578	0.0335
Schistosoma mansoni	multidrug resistance protein	0.001	0.0849	0.0955
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0849	0.0692
Echinococcus granulosus	multidrug resistance protein 1	0.001	0.0849	0.0692
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.8889	1
Toxoplasma gondii	microneme protein MIC17B	0.0014	0.2272	0.2339
Leishmania major	ATP-binding cassette protein subfamily G, member 4, putative	0.001	0.0578	0.0335
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0849	0.0692
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0849	0.0692
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0849	0.0692
Onchocerca volvulus		0.0014	0.2272	0.2072
Onchocerca volvulus		0.0031	0.8889	0.886
Echinococcus multilocularis	ATP binding cassette sub family B	0.001	0.076	0.0589
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0849	0.0692
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0849	0.0692
Brugia malayi	PAN domain containing protein	0.0014	0.2272	0.2272
Onchocerca volvulus		0.0014	0.2272	0.2072
Echinococcus multilocularis	aldo keto reductase	0.0031	0.8889	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0031	0.8889	1
Toxoplasma gondii	hypothetical protein	0.0014	0.2272	0.2339
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.8889	1
Toxoplasma gondii	hypothetical protein	0.0014	0.2272	0.2339
Leishmania major	hypothetical protein, conserved	0.0022	0.53	0.5179
Trichomonas vaginalis	aldo/keto reductase, putative	0.0031	0.8889	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.8889	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.8889	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.8889	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.8889	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.8889	1
Entamoeba histolytica	P-glycoprotein-2	0.001	0.0849	0.0692
Brugia malayi	Kringle domain containing protein	0.0022	0.53	0.53
Echinococcus multilocularis	multidrug resistance protein 1	0.001	0.0849	0.0692
Toxoplasma gondii	PAN domain-containing protein	0.0014	0.2272	0.2339
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.8889	1
Plasmodium vivax	multidrug resistance protein 1, putative	0.001	0.0849	0.1183
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.8889	1
Toxoplasma gondii	kringle domain-containing protein	0.0022	0.53	0.5845
Brugia malayi	PAN domain containing protein	0.0014	0.2272	0.2272
Toxoplasma gondii	aldose reductase, putative	0.0031	0.8889	1
Entamoeba histolytica	aldose reductase, putative	0.0031	0.8889	1
Onchocerca volvulus		0.0014	0.2272	0.2072
Brugia malayi	NADH-dependent xylose reductase	0.0009	0.0251	0.0251
Brugia malayi	PAN domain containing protein	0.0014	0.2272	0.2272
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0849	0.0692
Trichomonas vaginalis	abcb9, putative	0.001	0.0849	0.0692
Brugia malayi	PAN domain containing protein	0.0014	0.2272	0.2272
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0031	0.8889	0.8889
Loa Loa (eye worm)	PAN domain-containing protein	0.0014	0.2272	0.2272
Toxoplasma gondii	PAN domain-containing protein	0.0014	0.2272	0.2339
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0009	0.0251	0.0251
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0849	0.0692
Trypanosoma cruzi	aldo/keto reductase, putative	0.0031	0.8889	0.886
Brugia malayi	PAN domain containing protein	0.0014	0.2272	0.2272
Loa Loa (eye worm)	hypothetical protein	0.001	0.0849	0.0849
Loa Loa (eye worm)	oxidoreductase	0.0031	0.8889	0.8889
Loa Loa (eye worm)	PAN domain-containing protein	0.0014	0.2272	0.2272
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.001	0.0849	0.0692
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0014	0.2272	0.2339
Brugia malayi	PAN domain containing protein	0.0014	0.2272	0.2272
Echinococcus granulosus	aldo keto reductase	0.0031	0.8889	1
Trichomonas vaginalis	abcb9, putative	0.001	0.0849	0.0692
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.001	0.0849	0.0692
Loa Loa (eye worm)	blistered cuticle protein 3	0.0034	1	1
Leishmania major	ferric reductase, putative	0.0034	1	1
Entamoeba histolytica	ABC transporter, putative	0.001	0.0578	0.0378
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0849	0.0692
Echinococcus granulosus	aldo keto reductase	0.0031	0.8889	1
Onchocerca volvulus	Dual oxidase homolog	0.0034	1	1
Echinococcus granulosus	multidrug resistance protein 1	0.001	0.0849	0.0692
Trichomonas vaginalis	aldo/keto reductase, putative	0.0031	0.8889	1
Leishmania major	p-glycoprotein	0.001	0.0849	0.0613
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.8889	1
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.001	0.0849	0.0613
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0849	0.0692
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.8889	1
Toxoplasma gondii	microneme protein, putative	0.0014	0.2272	0.2339
Schistosoma mansoni	pol-related	0.0031	0.8889	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0031	0.8889	1
Schistosoma mansoni	hypothetical protein	0.0022	0.53	0.5963
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0849	0.0692
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.8889	1
Entamoeba histolytica	P-glycoprotein 5, putative	0.001	0.0849	0.0692
Brugia malayi	PAN domain containing protein	0.0014	0.2272	0.2272
Onchocerca volvulus		0.0031	0.8889	0.886
Trichomonas vaginalis	abcb9, putative	0.001	0.0849	0.0692
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0849	0.0692
Brugia malayi	ABC transporter family protein	0.001	0.0849	0.0849
Toxoplasma gondii	PAN domain-containing protein	0.0014	0.2272	0.2339
Loa Loa (eye worm)	oxidoreductase	0.0031	0.8889	0.8889
Onchocerca volvulus		0.0014	0.2272	0.2072
Trypanosoma brucei	aldo-keto reductase, putative	0.0031	0.8889	0.886
Loa Loa (eye worm)	oxidoreductase	0.0031	0.8889	0.8889
Entamoeba histolytica	P-glycoprotein-2, putative	0.001	0.0849	0.0692
Onchocerca volvulus		0.0014	0.2272	0.2072
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0849	0.0692
Loa Loa (eye worm)	PAN domain-containing protein	0.0014	0.2272	0.2272
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0849	0.0692

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 152 uM	The antiplatelet activity was tested by the turbidimetric method in washed human platelets using thrombin as agonist.	ChEMBL.	14698150
IC50 (functional)	= 152 uM	The antiplatelet activity was tested by the turbidimetric method in washed human platelets using thrombin as agonist.	ChEMBL.	14698150

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 181868