Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sortilin 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.2794 | 0.5256 |
Schistosoma mansoni | sortilin | 0.0059 | 0.3275 | 1 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.2794 | 0.5256 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.2794 | 0.5256 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.2794 | 0.8533 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.014 | 1 | 1 |
Plasmodium falciparum | sortilin | 0.0084 | 0.5316 | 0.5 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Toxoplasma gondii | sortilin, putative | 0.0084 | 0.5316 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0054 | 0.2794 | 0.2794 |
Echinococcus granulosus | sortilin | 0.0084 | 0.5316 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.2794 | 0.8533 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.014 | 1 | 1 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.2794 | 0.8533 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.2794 | 0.5256 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0054 | 0.2794 | 0.2794 |
Echinococcus multilocularis | sortilin | 0.0084 | 0.5316 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0034 | 0.0103 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Plasmodium vivax | sortilin, putative | 0.0084 | 0.5316 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.036 | 0.11 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.002 | 0 | 0.5 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0034 | 0.0103 |
Onchocerca volvulus | 0.002 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 170 nM | Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintillation proximity assay | ChEMBL. | 24355129 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.