Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | chromosome region maintenance protein 1/exportin, putative | 0.0141 | 0.0022 | 0.0225 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0284 | 0.0713 | 0.3599 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0284 | 0.0713 | 0.3599 |
Echinococcus granulosus | exportin 1 | 0.0337 | 0.0972 | 0.5161 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0284 | 0.0713 | 0.3599 |
Schistosoma mansoni | chromosome region maintenance protein 1/exportin | 0.0337 | 0.0972 | 0.5161 |
Trypanosoma cruzi | exportin 1, putative | 0.0337 | 0.0972 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0284 | 0.0713 | 0.3599 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0502 | 0.1773 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.085 | 0.0789 |
Brugia malayi | Importin-beta N-terminal domain containing protein | 0.0337 | 0.0972 | 0.0865 |
Loa Loa (eye worm) | nuclear export factor CRM1 | 0.0221 | 0.0408 | 0.0314 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0284 | 0.0713 | 0.3599 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0502 | 0.1773 | 0.1783 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0284 | 0.0713 | 0.3599 |
Trichomonas vaginalis | chromosome region maintenance protein, putative | 0.0141 | 0.0022 | 0.0225 |
Plasmodium vivax | exportin-1, putative | 0.0337 | 0.0972 | 0.5 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0284 | 0.0713 | 0.3599 |
Entamoeba histolytica | hypothetical protein | 0.0333 | 0.095 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0284 | 0.0713 | 0.3599 |
Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.0284 | 0.0713 | 0.3599 |
Loa Loa (eye worm) | hypothetical protein | 0.1915 | 0.8624 | 0.916 |
Echinococcus multilocularis | exportin 1 | 0.0337 | 0.0972 | 0.5161 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0284 | 0.0713 | 0.3599 |
Trichomonas vaginalis | chromosome region maintenance protein, putative | 0.0333 | 0.095 | 0.9775 |
Giardia lamblia | Hypothetical protein | 0.0221 | 0.0408 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0284 | 0.0713 | 0.3599 |
Loa Loa (eye worm) | hypothetical protein | 0.2076 | 0.9404 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0284 | 0.0713 | 0.3599 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0284 | 0.0713 | 0.3599 |
Schistosoma mansoni | chromosome region maintenance protein 1/exportin | 0.0333 | 0.095 | 0.5029 |
Trichomonas vaginalis | chromosome region maintenance protein, putative | 0.0337 | 0.0972 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0141 | 0.0022 | 0.0225 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0284 | 0.0713 | 0.0642 |
Toxoplasma gondii | exportin 1, putative | 0.0337 | 0.0972 | 0.5 |
Trichomonas vaginalis | pten, drome, putative | 0.0161 | 0.0117 | 0.1202 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.0287 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.1915 | 0.8624 | 0.916 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.0284 | 0.0713 | 0.3599 |
Leishmania major | exportin 1, putative | 0.0337 | 0.0972 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0284 | 0.0713 | 0.3599 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0284 | 0.0713 | 0.3599 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0502 | 0.1773 | 1 |
Trypanosoma brucei | exportin 1 | 0.0337 | 0.0972 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0141 | 0.0022 | 0.0225 |
Plasmodium falciparum | exportin-1, putative | 0.0337 | 0.0972 | 0.5 |
Onchocerca volvulus | 0.2038 | 0.922 | 1 | |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0502 | 0.1773 | 1 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0502 | 0.1773 | 0.1676 |
Loa Loa (eye worm) | hypothetical protein | 0.1915 | 0.8624 | 0.916 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 76.03 nM | Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay | ChEMBL. | 24316669 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.