TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 530.83 | Formula: C26H22Cl3N3O3
H donors: 1 H acceptors: 3 LogP: 5.84 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: COc1cc(CNC(=O)c2cc(cnc2c2cccnc2)c2cc(Cl)cc(c2)Cl)ccc1OC.Cl
InChi: 1S/C26H21Cl2N3O3.ClH/c1-33-23-6-5-16(8-24(23)34-2)13-31-26(32)22-11-19(18-9-20(27)12-21(28)10-18)15-30-25(22)17-4-3-7-29-14-17;/h3-12,14-15H,13H2,1-2H3,(H,31,32);1H
InChiKey: HRJJWOTVUSQJAP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	neuropeptide s receptor	0.0019	0.0027	0.0088
Schistosoma mansoni	biogenic amine receptor	0.0019	0.0027	0.0027
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0019	0.0027	0.0086
Mycobacterium ulcerans	glycerol-3-phosphate dehydrogenase GlpD2	0.022	0.0792	0.0759
Schistosoma mansoni	glycerol-3-phosphate dehydrogenase	0.022	0.0792	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Schistosoma mansoni	patched 1	0.0048	0.0137	0.0137
Brugia malayi	hypothetical protein	0.0019	0.0027	0.0171
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 20	0.022	0.0792	1
Echinococcus granulosus	allatostatin A receptor	0.0019	0.0027	0.0086
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0027	0.0088
Echinococcus multilocularis	g-protein coupled receptor	0.0019	0.0027	0.0088
Brugia malayi	follicle stimulating hormone receptor	0.0019	0.0027	0.0171
Loa Loa (eye worm)	TYRA-2 protein	0.0019	0.0027	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Schistosoma mansoni	neuropeptide F-like receptor	0.0019	0.0027	0.0027
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0019	0.0027	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0166	0.0587	0.0587
Brugia malayi	CHE-14 protein	0.0048	0.0137	0.0963
Schistosoma mansoni	d-amino acid oxidase	0.2638	1	1
Loa Loa (eye worm)	glycerol-3-phosphate dehydrogenase	0.022	0.0792	0.0789
Onchocerca volvulus		0.0141	0.0492	0.6075
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.0027	0.0027
Trypanosoma cruzi	FAD dependent oxidoreductase, putative	0.022	0.0792	1
Echinococcus granulosus	sex peptide receptor	0.0019	0.0027	0.0086
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0036	0.5
Echinococcus multilocularis	somatostatin receptor	0.0019	0.0027	0.0088
Schistosoma mansoni	ap endonuclease	0.0021	0.0036	0.0036
Brugia malayi	hypothetical protein	0.0019	0.0027	0.0171
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0104	0.0349	0.2499
Echinococcus multilocularis	sterol regulatory element binding protein	0.0048	0.0137	0.0438
Echinococcus granulosus	hypothetical protein	0.0852	0.32	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0104	0.0349	0.0349
Echinococcus granulosus	Niemann Pick C1 protein	0.0112	0.038	0.1186
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0048	0.0137	0.0134
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.014	0.014
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0019	0.0027	0.0086
Brugia malayi	Dopamine receptor protein 1	0.0019	0.0027	0.0171
Schistosoma mansoni	cell adhesion molecule	0.0013	0.0003	0.0003
Toxoplasma gondii	FAD-dependent glycerol-3-phosphate dehydrogenase	0.022	0.0792	1
Echinococcus granulosus	fmrfamide receptor	0.0019	0.0027	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Loa Loa (eye worm)	hypothetical protein	0.022	0.0792	0.0789
Onchocerca volvulus	Tyrosine kinase homolog	0.0145	0.0508	0.6293
Schistosoma mansoni	biogenic amine receptor	0.0019	0.0027	0.0027
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0019	0.0027	0.0025
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0222	0.0801	0.2562
Loa Loa (eye worm)	hypothetical protein	0.022	0.0792	0.0789
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Brugia malayi	G protein-coupled receptor	0.0019	0.0027	0.0171
Brugia malayi	hypothetical protein	0.0019	0.0027	0.0171
Echinococcus multilocularis	protein patched	0.0048	0.0137	0.0438
Echinococcus granulosus	biogenic amine 5HT receptor	0.0166	0.0587	0.1835
Schistosoma mansoni	ATP:guanidino kinase (Smc74)	0.022	0.0792	0.0792
Echinococcus granulosus	roundabout 2	0.0015	0.0012	0.0037
Schistosoma mansoni	opsin-like receptor	0.0019	0.0027	0.0027
Trypanosoma brucei	FAD dependent oxidoreductase, putative	0.022	0.0792	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Brugia malayi	RE15519p	0.0019	0.0027	0.0171
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0027	0.0086
Plasmodium falciparum	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.022	0.0792	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0027	0.0086
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0013	0.0004	0.0012
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0019	0.0027	0.0025
Toxoplasma gondii	hypothetical protein	0.022	0.0792	1
Echinococcus multilocularis	protein dispatched 1	0.0055	0.0163	0.052
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0019	0.0027	0.0086
Brugia malayi	neuropeptide F receptor	0.0019	0.0027	0.0171
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0004	0.0004
Echinococcus granulosus	orexin receptor type 2	0.0019	0.0027	0.0086
Echinococcus multilocularis	G protein coupled receptor 139	0.0143	0.0497	0.1591
Brugia malayi	hypothetical protein	0.0019	0.0027	0.0171
Schistosoma mansoni	hypothetical protein	0.0046	0.013	0.013
Loa Loa (eye worm)	melatonin receptor type 1A	0.0019	0.0027	0.0025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0027	0.0027
Echinococcus granulosus	voltage gated potassium channel	0.0013	0.0004	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0019	0.0027	0.0086
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0019	0.0027	0.0088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0104	0.0349	0.1092
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0113	0.0386	0.0386
Schistosoma mansoni	histamine h1 receptor	0.0019	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0012	0.0009
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0113	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Onchocerca volvulus	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog	0.022	0.0792	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.0124	0.0397
Brugia malayi	cDNA sequence BC016226	0.022	0.0792	0.5697
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0036	0.0033
Echinococcus granulosus	neuropeptide Y receptor	0.0019	0.0027	0.0086
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0027	0.0027
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0019	0.0027	0.0027
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0027	0.0088
Schistosoma mansoni	myosin xvIII	0.0019	0.0027	0.0027
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.0124	0.0871
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0027	0.0086
Schistosoma mansoni	neuropeptide f receptor 76f	0.0019	0.0027	0.0027
Brugia malayi	Dopamine receptor protein 2	0.0019	0.0027	0.0171
Chlamydia trachomatis	D-amino acid dehydrogenase	0.022	0.0792	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0027	0.0027
Schistosoma mansoni	amine GPCR	0.0019	0.0027	0.0027
Schistosoma mansoni	hypothetical protein	0.0019	0.0027	0.0027
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0027	0.0088
Brugia malayi	G protein-coupled receptor F59B2.13	0.0019	0.0027	0.0171
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0019	0.0027	0.0171
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0027	0.0088
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0013	0.0003	0.0008
Echinococcus multilocularis	orexin receptor type 2	0.0019	0.0027	0.0088
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0027	0.0088
Leishmania major	hypothetical protein, conserved	0.022	0.0792	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0019	0.0027	0.0088
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.022	0.0792	1
Echinococcus granulosus	neuropeptides capa receptor	0.0019	0.0027	0.0086
Brugia malayi	putative neuropeptide receptor NPR1	0.0019	0.0027	0.0171
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0027	0.0027
Echinococcus multilocularis	neuropeptide Y receptor	0.0019	0.0027	0.0088
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0019	0.0027	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Schistosoma mansoni	fad oxidoreductase	0.022	0.0792	0.0792
Echinococcus multilocularis	neuropeptide receptor	0.0019	0.0027	0.0088
Leishmania major	hypothetical protein, conserved	0.022	0.0792	1
Echinococcus multilocularis	voltage gated potassium channel	0.0013	0.0004	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Loa Loa (eye worm)	hypothetical protein	0.022	0.0792	0.0789
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0019	0.0027	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0019	0.0027	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0102	0.0099
Echinococcus multilocularis	glycerol 3 phosphate dehydrogenase	0.022	0.0792	0.2532
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0027	0.0086
Entamoeba histolytica	NAD(FAD)-dependent dehydrogenase, putative	0.022	0.0792	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0137	0.0134
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.0124	0.0122
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase, putative	0.022	0.0792	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0019	0.0027	0.0088
Echinococcus granulosus	neuropeptide FF receptor 2	0.0019	0.0027	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0376	0.1387	0.1385
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Brugia malayi	hypothetical protein	0.0019	0.0027	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0019	0.0027	0.0088
Loa Loa (eye worm)	neuropeptide F receptor	0.0019	0.0027	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Mycobacterium ulcerans	glycerol-3-phosphate dehydrogenase	0.022	0.0792	0.0759
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Schistosoma mansoni	hypothetical protein	0.0019	0.0027	0.0027
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.2638	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0019	0.0027	0.0027
Schistosoma mansoni	NAD dehydrogenase	0.022	0.0792	0.0792
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0027	0.0088
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0027	0.0027
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0376	0.1387	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0019	0.0027	0.0027
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0036	0.0112
Brugia malayi	putative neuropeptide receptor	0.0019	0.0027	0.0171
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0019	0.0027	0.0027
Schistosoma mansoni	hypothetical protein	0.0019	0.0027	0.0027
Echinococcus granulosus	raf serine:threonine protein kinase	0.0222	0.0801	0.2504
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Echinococcus multilocularis	FAD dependent oxidoreductase domain containing protein	0.022	0.0792	0.2532
Brugia malayi	G-protein coupled receptor	0.0019	0.0027	0.0171
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0019	0.0027	0.0027
Brugia malayi	GnHR receptor homolog	0.0019	0.0027	0.0171
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0027	0.0027
Schistosoma mansoni	ap endonuclease	0.0021	0.0036	0.0036
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0027	0.0088
Echinococcus multilocularis	sex peptide receptor	0.0019	0.0027	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Echinococcus granulosus	somatostatin receptor	0.0019	0.0027	0.0086
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0019	0.0027	0.0086
Echinococcus granulosus	7TM GPCR rhodopsin	0.0019	0.0027	0.0086
Schistosoma mansoni	opsin-like receptor	0.0019	0.0027	0.0027
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0112	0.038	0.4547
Trypanosoma brucei	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.022	0.0792	1
Brugia malayi	AKH receptor	0.0019	0.0027	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0027	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0178	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Echinococcus granulosus	g-protein coupled receptor	0.0019	0.0027	0.0086
Echinococcus multilocularis	expressed conserved protein	0.0105	0.0354	0.1131
Mycobacterium ulcerans	thiamine biosynthesis oxidoreductase ThiO	0.022	0.0792	0.0759
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Brugia malayi	neuropeptide F receptor	0.0019	0.0027	0.0171
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0036	0.0232
Echinococcus granulosus	FAD dependent oxidoreductase domain containing protein	0.022	0.0792	0.2474
Mycobacterium tuberculosis	Possible thiamine biosynthesis oxidoreductase ThiO	0.022	0.0792	0.0828
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0027	0.0086
Echinococcus multilocularis	fmrfamide receptor	0.0019	0.0027	0.0088
Leishmania major	glycerol-3-phosphate dehydrogenase-like protein	0.022	0.0792	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0019	0.0027	0.0088
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0027	0.0086
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0027	0.0088
Loa Loa (eye worm)	G-protein coupled receptor	0.0019	0.0027	0.0025
Schistosoma mansoni	hypothetical protein	0.0019	0.0027	0.0027
Schistosoma mansoni	serine/threonine protein kinase	0.0222	0.0801	0.0801
Echinococcus granulosus	expressed conserved protein	0.0105	0.0354	0.1105
Echinococcus multilocularis	neuropeptides capa receptor	0.0019	0.0027	0.0088
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0036	0.0114
Echinococcus multilocularis	dro:myosuppressin receptor	0.0019	0.0027	0.0088
Echinococcus multilocularis	serotonin receptor	0.0166	0.0587	0.1878
Brugia malayi	Raf kinase	0.0215	0.0772	0.5552
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0004	0.0004
Echinococcus granulosus	dro:myosuppressin receptor	0.0019	0.0027	0.0086
Schistosoma mansoni	amine GPCR	0.0019	0.0027	0.0027
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0019	0.0027	0.0027
Echinococcus multilocularis	allatostatin A receptor	0.0019	0.0027	0.0088
Giardia lamblia	Glycerol-3-phosphate dehydrogenase	0.022	0.0792	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0019	0.0027	0.0025
Brugia malayi	hypothetical protein	0.0019	0.0027	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0019	0.0027	0.0027
Schistosoma mansoni	biogenic amine receptor	0.0019	0.0027	0.0027
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0027	0.0027
Echinococcus multilocularis	neuropeptide Y receptor	0.0019	0.0027	0.0088
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.0027	0.0027
Loa Loa (eye worm)	G-protein coupled receptor	0.0019	0.0027	0.0025
Echinococcus granulosus	glycerol 3 phosphate dehydrogenase	0.022	0.0792	0.2474
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0019	0.0027	0.0171
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0027	0.0088
Onchocerca volvulus	Dimethylglycine dehydrogenase, mitochondrial homolog	0.022	0.0792	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0019	0.0027	0.0086
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0027	0.0086
Schistosoma mansoni	hypothetical protein	0.0046	0.013	0.013
Echinococcus multilocularis	neuropeptide receptor	0.0143	0.0497	0.1591
Echinococcus granulosus	Niemann Pick C1 protein	0.016	0.0562	0.1756
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0027	0.0088
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0019	0.0027	0.0088
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0027	0.0027
Schistosoma mansoni	vesicular amine transporter	0.0012	0.0002	0.0002
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0019	0.0027	0.0088
Trypanosoma brucei	electron transfer flavoprotein-ubiquinone oxidoreductase, putative	0.022	0.0792	1
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0027	0.0027
Mycobacterium leprae	PROBABLE D-AMINO ACID OXIDASE AAO	0.2638	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0027	0.0027
Schistosoma mansoni	fad oxidoreductase	0.022	0.0792	0.0792
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0019	0.0027	0.0025
Echinococcus multilocularis	neuropeptides capa receptor	0.0019	0.0027	0.0088
Echinococcus granulosus	neuropeptide s receptor	0.0019	0.0027	0.0086
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0019	0.0027	0.0025
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.022	0.0792	1
Brugia malayi	Dopamine receptor	0.0019	0.0027	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Brugia malayi	Niemann-Pick C1 protein precursor	0.0112	0.038	0.2717
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.0124	0.0388
Loa Loa (eye worm)	neuropeptide F receptor	0.0019	0.0027	0.0025
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.022	0.0792	1
Echinococcus multilocularis	serotonin receptor	0.0166	0.0587	0.1878
Echinococcus granulosus	biogenic amine 5HT receptor	0.0019	0.0027	0.0086
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0027	0.0086
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0027	0.0088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0104	0.0349	0.0347
Plasmodium vivax	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.022	0.0792	1
Schistosoma mansoni	adenoreceptor	0.0019	0.0027	0.0027
Echinococcus granulosus	Protein patched homolog 1	0.0048	0.0137	0.0428
Brugia malayi	RE18450p	0.022	0.0792	0.5697
Loa Loa (eye worm)	hypothetical protein	0.0112	0.038	0.0377
Brugia malayi	Serotonin receptor	0.0019	0.0027	0.0171
Echinococcus granulosus	7tm_1 domain containing protein	0.0019	0.0027	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Brugia malayi	pyruvate dehydrogenase phosphatase regulatory subunit precursor	0.022	0.0792	0.5697
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0019	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0587	0.0585
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0019	0.0027	0.0086
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0019	0.0027	0.0171
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0019	0.0027	0.0088
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0156	0.0547	0.3929
Brugia malayi	larval opioid receptor	0.0019	0.0027	0.0171
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0027	0.0086
Echinococcus granulosus	G protein coupled receptor 139	0.0019	0.0027	0.0086
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0019	0.0027	0.0171
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0019	0.0027	0.0027
Brugia malayi	Melatonin receptor type 1A	0.0019	0.0027	0.0171
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0027	0.0088
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0027	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0004	0.0001
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0104	0.0349	0.1117
Brugia malayi	hypothetical protein	0.0019	0.0027	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.022	0.0792	1
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0137	1
Echinococcus multilocularis	fmrfamide receptor	0.0019	0.0027	0.0088
Echinococcus granulosus	neuropeptide receptor	0.0143	0.0497	0.1554
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0027	0.0086
Brugia malayi	Serotonin receptor	0.0019	0.0027	0.0171
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0104	0.0349	0.1092
Brugia malayi	G-protein coupled receptor	0.0019	0.0027	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Echinococcus multilocularis	roundabout 2	0.0015	0.0012	0.0038
Schistosoma mansoni	growth hormone secretagogue receptor	0.0019	0.0027	0.0027
Echinococcus multilocularis	conserved hypothetical protein	0.0833	0.3127	1
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0027	0.0086
Schistosoma mansoni	hypothetical protein	0.0046	0.013	0.013
Brugia malayi	hypothetical protein	0.0019	0.0027	0.0171
Loa Loa (eye worm)	raf kinase	0.022	0.0794	0.0791
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.014	0.014
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0126	0.0436	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Echinococcus multilocularis	Niemann Pick C1 protein	0.0112	0.038	0.1214
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0019	0.0027	0.0027
Schistosoma mansoni	amine GPCR	0.0019	0.0027	0.0027
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0019	0.0027	0.0088
Echinococcus granulosus	sterol regulatory element binding protein	0.0048	0.0137	0.0428
Schistosoma mansoni	hypothetical protein	0.0046	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0587	0.0585
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0019	0.0027	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Brugia malayi	hypothetical protein	0.0019	0.0027	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0012	0.0009
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0376	0.1387	0.1387
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0027	0.0086
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0013	0.0004	0.0011
Entamoeba histolytica	anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative	0.022	0.0792	1
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0027	0.0027
Schistosoma mansoni	neuropeptide receptor	0.0143	0.0497	0.0497
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0027	0.0086
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0156	0.0547	0.0545
Echinococcus multilocularis	Niemann Pick C1 protein	0.016	0.0562	0.1797
Echinococcus granulosus	neuropeptides capa receptor	0.0019	0.0027	0.0086
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0019	0.0027	0.0086
Echinococcus granulosus	neuropeptide receptor A26	0.0019	0.0027	0.0086
Schistosoma mansoni	amine GPCR	0.0019	0.0027	0.0027
Echinococcus granulosus	serotonin receptor	0.0019	0.0027	0.0086
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0104	0.0349	0.1117
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0019	0.0027	0.0088
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.022	0.0792	0.0759
Schistosoma mansoni	amine GPCR	0.0019	0.0027	0.0027
Echinococcus granulosus	neuropeptide Y receptor	0.0019	0.0027	0.0086
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0019	0.0027	0.0171
Brugia malayi	dimethylglycine dehydrogenase, mitochondrial precursor, putative	0.022	0.0792	0.5697
Mycobacterium tuberculosis	Probable D-amino acid oxidase Aao	0.2418	0.9163	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0019	0.0027	0.0027
Brugia malayi	hypothetical protein	0.0019	0.0027	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Brugia malayi	ORL1-like opioid receptor	0.0019	0.0027	0.0171
Schistosoma mansoni	opsin-like receptor	0.0019	0.0027	0.0027
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0113	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0036	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0104	0.0349	0.0349
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.022	0.0792	1
Brugia malayi	sulfakinin receptor protein	0.0019	0.0027	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0376	0.1387	0.1385
Echinococcus granulosus	neuropeptide receptor	0.0019	0.0027	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0025
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial	0.022	0.0792	1
Onchocerca volvulus	Putative fad oxidoreductase	0.022	0.0792	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0019	0.0027	0.0027
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0104	0.0349	0.0349

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3099978

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1821139