Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0495 | 0.0096 | 0.5 | |
Giardia lamblia | Hypothetical protein | 0.0495 | 0.0096 | 0.5 |
Echinococcus granulosus | potassium channel subfamily K | 0.0495 | 0.0096 | 0.0096 |
Toxoplasma gondii | ion channel protein | 0.0495 | 0.0096 | 0.5 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.0495 | 0.0096 | 0.5 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0495 | 0.0096 | 0.0096 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.0495 | 0.0096 | 0.5 |
Onchocerca volvulus | 0.0495 | 0.0096 | 0.5 | |
Onchocerca volvulus | 0.0495 | 0.0096 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0495 | 0.0096 | 0.5 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0495 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.8222 | 1 | 1 |
Echinococcus granulosus | calcium activated potassium channel variant | 0.0495 | 0.0096 | 0.0096 |
Echinococcus granulosus | twik family of potassium channels | 0.0495 | 0.0096 | 0.0096 |
Plasmodium falciparum | potassium channel | 0.0495 | 0.0096 | 0.5 |
Toxoplasma gondii | ion channel protein | 0.0495 | 0.0096 | 0.5 |
Plasmodium falciparum | potassium channel | 0.0495 | 0.0096 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0495 | 0.0096 | 0.0096 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0495 | 0.0096 | 0.0096 |
Echinococcus granulosus | potassium channel subfamily K 8 | 0.0495 | 0.0096 | 0.0096 |
Echinococcus multilocularis | potassium channel subfamily K 8 | 0.0495 | 0.0096 | 0.0096 |
Leishmania major | calcium/potassium channel (CAKC), putative | 0.0495 | 0.0096 | 0.5 |
Echinococcus multilocularis | calcium activated potassium channel variant | 0.0495 | 0.0096 | 0.0096 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0495 | 0.0096 | 0.0096 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0495 | 0.0096 | 0.0096 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0495 | 0.0096 | 0.0096 |
Entamoeba histolytica | calcium-gated potassium channel protein, putative | 0.0495 | 0.0096 | 0.5 |
Trypanosoma cruzi | ion transport protein, putative | 0.0495 | 0.0096 | 0.5 |
Leishmania major | ion transport protein-like protein | 0.0495 | 0.0096 | 0.5 |
Echinococcus granulosus | twik family of potassium channels | 0.0495 | 0.0096 | 0.0096 |
Echinococcus multilocularis | Two pore potassium channel protein sup 9 | 0.8222 | 1 | 1 |
Onchocerca volvulus | 0.0495 | 0.0096 | 0.5 | |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0495 | 0.0096 | 0.0096 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0495 | 0.0096 | 0.5 |
Trypanosoma brucei | calcium-activated potassium channel, putative | 0.0495 | 0.0096 | 0.5 |
Mycobacterium ulcerans | transmembrane cation transporter | 0.0495 | 0.0096 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0495 | 0.0096 | 0.5 |
Plasmodium vivax | potassium channel, putative | 0.0495 | 0.0096 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.7727 | 0.9366 | 0.936 |
Echinococcus multilocularis | potassium channel subfamily K 8 | 0.0495 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.8222 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0495 | 0.0096 | 0.5 |
Plasmodium vivax | potassium channel, putative | 0.0495 | 0.0096 | 0.5 |
Trypanosoma brucei | calcium/potassium channel (CAKC), putative | 0.0495 | 0.0096 | 0.5 |
Schistosoma mansoni | twik family of potassium channels-related | 0.8222 | 1 | 1 |
Onchocerca volvulus | 0.0495 | 0.0096 | 0.5 | |
Echinococcus granulosus | small conductance calcium activated potassium | 0.0495 | 0.0096 | 0.0096 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0495 | 0.0096 | 0.5 |
Leishmania major | potassium channel subunit-like protein | 0.0495 | 0.0096 | 0.5 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.0495 | 0.0096 | 0.5 |
Onchocerca volvulus | 0.0495 | 0.0096 | 0.5 | |
Echinococcus granulosus | potassium channel subfamily K 8 | 0.0495 | 0.0096 | 0.0096 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0495 | 0.0096 | 0.0096 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0495 | 0.0096 | 0.0096 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0495 | 0.0096 | 0.0096 |
Mycobacterium ulcerans | ion transport protein | 0.0495 | 0.0096 | 0.5 |
Onchocerca volvulus | 0.0495 | 0.0096 | 0.5 | |
Leishmania major | hypothetical protein, conserved | 0.0495 | 0.0096 | 0.5 |
Echinococcus multilocularis | potassium channel subfamily K | 0.0495 | 0.0096 | 0.0096 |
Schistosoma mansoni | hypothetical protein | 0.0495 | 0.0096 | 0.0096 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0495 | 0.0096 | 0.5 |
Onchocerca volvulus | 0.0495 | 0.0096 | 0.5 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0495 | 0.0096 | 0.5 |
Trypanosoma cruzi | ion transport protein, putative | 0.0495 | 0.0096 | 0.5 |
Echinococcus multilocularis | twik family of potassium channels | 0.0495 | 0.0096 | 0.0096 |
Echinococcus granulosus | Two pore potassium channel protein sup 9 | 0.8222 | 1 | 1 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.0495 | 0.0096 | 0.5 |
Echinococcus multilocularis | TWiK family of potassium channels protein 7 | 0.0495 | 0.0096 | 0.0096 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0495 | 0.0096 | 0.0096 |
Echinococcus granulosus | TWiK family of potassium channels protein 7 | 0.0495 | 0.0096 | 0.0096 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0495 | 0.0096 | 0.5 |
Echinococcus multilocularis | twik family of potassium channels | 0.0495 | 0.0096 | 0.0096 |
Mycobacterium tuberculosis | Possible transmembrane cation transporter | 0.0495 | 0.0096 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1.56 ug ml-1 | Antibacterial activity against Mycobacterium tuberculosis H37Rv assessed as parasite growth inhibition after 6 days by microplate Alamar Blue assay | ChEMBL. | 24266862 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.