Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | platelet derived growth factor receptor, beta polypeptide | Starlite/ChEMBL | References |
Homo sapiens | colony stimulating factor 1 receptor | Starlite/ChEMBL | References |
Homo sapiens | kinase insert domain receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | TK/KIN16 protein kinase | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Onchocerca volvulus | Tyrosine kinase homolog | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Brugia malayi | Immunoglobulin I-set domain containing protein | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Onchocerca volvulus | Get druggable targets OG5_130320 | All targets in OG5_130320 | |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | Get druggable targets OG5_132967 | All targets in OG5_132967 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.2036 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0164 | 0.0104 |
Echinococcus granulosus | twitchin | 0.0061 | 0.0192 | 0.0192 |
Giardia lamblia | Kinase, CMGC MAPK | 0.2036 | 1 | 0.5 |
Plasmodium falciparum | protein kinase, putative | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0052 | 0.015 | 0.015 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.2036 | 1 | 1 |
Schistosoma mansoni | nephrin | 0.0042 | 0.01 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0086 | 0.0026 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.2036 | 1 | 1 |
Echinococcus multilocularis | neuroglian | 0.0042 | 0.01 | 0.01 |
Echinococcus multilocularis | Immunoglobulin | 0.0039 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.015 | 0.009 |
Echinococcus multilocularis | Immunoglobulin | 0.0039 | 0.0086 | 0.0086 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.2036 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.2036 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2036 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0164 | 0.0104 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0086 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0086 | 0.0026 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.2036 | 1 | 1 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0039 | 0.0086 | 0.0086 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2036 | 1 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0222 | 0.0995 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0086 | 0.0026 |
Echinococcus granulosus | defective proboscis extension response | 0.0039 | 0.0086 | 0.0086 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2036 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0086 | 0.0026 |
Echinococcus multilocularis | roundabout 2 | 0.0055 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0222 | 0.0995 | 0.094 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0086 | 0.0026 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0039 | 0.0086 | 0.0086 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.0504 | 0.2391 | 0.2391 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0039 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.2036 | 1 | 1 |
Echinococcus granulosus | neuroglian | 0.0042 | 0.01 | 0.01 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0173 | 0.075 | 1 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0052 | 0.015 | 0.015 |
Schistosoma mansoni | vesicular amine transporter | 0.0039 | 0.0086 | 0.0086 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.2036 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.2036 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.2036 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2036 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.2036 | 1 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0055 | 0.0164 | 0.0164 |
Echinococcus granulosus | Immunoglobulin | 0.0039 | 0.0086 | 0.0086 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.2036 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.2036 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0022 | 0 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.2036 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2036 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9 nM | Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluorescence assay | ChEMBL. | 24900776 |
IC50 (binding) | = 42 nM | Inhibition of KDR (unknown origin) | ChEMBL. | 24900776 |
IC50 (binding) | = 312 nM | Inhibition of cFMS (unknown origin) | ChEMBL. | 24900776 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.