Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | P2X receptor subunit | 0.1181 | 1 | 1 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0026 | 0.0026 |
Schistosoma mansoni | P2X receptor subunit | 0.1181 | 1 | 1 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0026 | 0.0026 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0026 | 0.0026 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0011 | 0.0026 | 0.0026 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.1181 | 1 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0219 | 0.1803 | 1 |
Trypanosoma cruzi | guanine nucleotide releasing protein, putative | 0.0008 | 0 | 0.5 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.1181 | 1 | 1 |
Trichomonas vaginalis | ras GTP exchange factor, son of sevenless, putative | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0026 | 0.0026 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.1803 | 1 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0026 | 0.0146 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.0607 | 0.5106 | 1 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0026 | 0.0026 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.1181 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.1181 | 1 | 1 |
Trichomonas vaginalis | guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0026 | 0.0146 |
Mycobacterium leprae | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.0607 | 0.5106 | 0.5 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0026 | 0.0026 |
Brugia malayi | N-terminal motif family protein | 0.0219 | 0.1803 | 1 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0026 | 0.0146 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0011 | 0.0026 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | dep domain containing protein | 0.0011 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0026 | 0.0146 |
Onchocerca volvulus | 0.0011 | 0.0026 | 0.0146 | |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0026 | 0.0026 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0011 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0011 | 0.0026 | 0.0146 |
Brugia malayi | DIX domain containing protein | 0.0011 | 0.0026 | 0.0146 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.1181 | 1 | 1 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0026 | 0.0146 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0026 | 0.0026 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0111 | 0.0883 | 1 |
Treponema pallidum | licC protein (licC) | 0.0111 | 0.0883 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0026 | 0.0026 |
Trypanosoma cruzi | hypothetical protein | 0.0008 | 0 | 0.5 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0011 | 0.0026 | 0.0146 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.1181 | 1 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.0607 | 0.5106 | 1 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0011 | 0.0026 | 0.0146 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0011 | 0.0026 | 0.0026 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.1181 | 1 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0026 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0607 | 0.5106 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0011 | 0.0026 | 0.0026 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0026 | 0.0146 |
Schistosoma mansoni | regulator of G protein signaling | 0.0011 | 0.0026 | 0.0026 |
Trypanosoma cruzi | hypothetical protein | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of Streptococcus pyogenes UMAA2616 streptokinase assessed as plasmin activity in human plasma after 24 hrs by colorimetric analysis | ChEMBL. | 24559768 | |
T/C (binding) | = 1.07 | Inhibition of Streptococcus pyogenes UMAA2616 streptokinase assessed as plasmin activity in human plasma at 5 uM after 24 hrs by colorimetric analysis relative to control | ChEMBL. | 24559768 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.