Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0026 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0011 | 0.0026 | 0.0026 |
Mycobacterium leprae | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.0607 | 0.5106 | 0.5 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0026 | 0.0026 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0026 | 0.0026 |
Trypanosoma cruzi | hypothetical protein | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0011 | 0.0026 | 0.0146 |
Trypanosoma cruzi | hypothetical protein | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0011 | 0.0026 | 0.0146 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0026 | 0.0026 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.0607 | 0.5106 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.1181 | 1 | 1 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0011 | 0.0026 | 0.0026 |
Trichomonas vaginalis | ras GTP exchange factor, son of sevenless, putative | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling | 0.0011 | 0.0026 | 0.0026 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0219 | 0.1803 | 1 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0011 | 0.0026 | 0.0026 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0026 | 0.0026 |
Trichomonas vaginalis | guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0026 | 0.0026 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Trypanosoma cruzi | guanine nucleotide releasing protein, putative | 0.0008 | 0 | 0.5 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0011 | 0.0026 | 0.0146 |
Treponema pallidum | licC protein (licC) | 0.0111 | 0.0883 | 0.5 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0008 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0607 | 0.5106 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0026 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.1803 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0026 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.1181 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.1181 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.1181 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.1181 | 1 | 1 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.0607 | 0.5106 | 1 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0026 | 0.0026 |
Brugia malayi | DIX domain containing protein | 0.0011 | 0.0026 | 0.0146 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0026 | 0.0026 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0026 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | dep domain containing protein | 0.0011 | 0.0026 | 0.0026 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0011 | 0.0026 | 0.0146 |
Brugia malayi | N-terminal motif family protein | 0.0219 | 0.1803 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.1181 | 1 | 1 |
Onchocerca volvulus | 0.0011 | 0.0026 | 0.0146 | |
Echinococcus granulosus | p2X purinoceptor 4 | 0.1181 | 1 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.1181 | 1 | 1 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0011 | 0.0026 | 0.0026 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.1181 | 1 | 1 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0026 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0111 | 0.0883 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0026 | 0.0146 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0008 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0026 | 0.0146 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0026 | 0.0026 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0026 | 0.0026 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of Streptococcus pyogenes UMAA2616 streptokinase assessed as plasmin activity in human plasma after 24 hrs by colorimetric analysis | ChEMBL. | 24559768 | |
T/C (binding) | = 1.07 | Inhibition of Streptococcus pyogenes UMAA2616 streptokinase assessed as plasmin activity in human plasma at 5 uM after 24 hrs by colorimetric analysis relative to control | ChEMBL. | 24559768 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.