Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycogen synthase kinase 3 beta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0079 | 0.9996 | 0.9985 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0059 | 0.7356 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0059 | 0.7356 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0059 | 0.7356 | 0.7356 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0059 | 0.7356 | 0.5 |
Onchocerca volvulus | 0.0059 | 0.7356 | 0.5 | |
Brugia malayi | intracellular kinase | 0.0059 | 0.7356 | 0.5 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0059 | 0.7356 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0079 | 1 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0079 | 0.9996 | 0.9985 |
Trypanosoma brucei | protein kinase, putative | 0.0059 | 0.7356 | 1 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0059 | 0.7356 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0079 | 1 | 1 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0059 | 0.7356 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0059 | 0.7356 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0079 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0079 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0059 | 0.7356 | 0.7356 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0059 | 0.7356 | 0.5 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0059 | 0.7356 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0059 | 0.7356 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0059 | 0.7356 | 0.7356 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0059 | 0.7356 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 51 nM | Inhibition of human recombinant GSK-3beta using prephosphorylated GS1 peptide and [gamma-32P]ATP as substrate after 1 hr by liquid scintillation spectrometry | ChEMBL. | 24176395 |
IC50 (ADMET) | = 23.1 uM | Inhibition of recombinant human CYP1A2 | ChEMBL. | 24176395 |
IC50 (ADMET) | = 47.4 uM | Inhibition of recombinant human CYP2D6 | ChEMBL. | 24176395 |
IC50 (ADMET) | > 50 uM | Inhibition of recombinant human CYP3A4 | ChEMBL. | 24176395 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.