Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | sonic hedgehog | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K06224 hedgehog, putative | Get druggable targets OG5_131225 | All targets in OG5_131225 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0414 | 0.0791 | 0.0791 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0414 | 0.0791 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0414 | 0.0791 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0414 | 0.0791 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0414 | 0.0791 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2602 | 1 | 1 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0414 | 0.0791 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0414 | 0.0791 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.2602 | 1 | 1 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0414 | 0.0791 | 0.0791 |
Toxoplasma gondii | hypothetical protein | 0.0414 | 0.0791 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0414 | 0.0791 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0414 | 0.0791 | 0.0791 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.2602 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0414 | 0.0791 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0414 | 0.0791 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.2602 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0414 | 0.0791 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.2602 | 1 | 1 |
Leishmania major | glutaminyl cyclase, putative | 0.0414 | 0.0791 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0414 | 0.0791 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0414 | 0.0791 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0414 | 0.0791 | 0.0791 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0414 | 0.0791 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0414 | 0.0791 | 0.0791 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10.6 nM | Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assay | ChEMBL. | 24176396 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.