Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 7 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 8 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 9 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | serine carboxypeptidase S28, putative | dipeptidyl-peptidase 7 | 492 aa | 471 aa | 25.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.2681 | 0.2419 | 0.2398 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0345 | 0.0156 | 0.013 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.2681 | 0.2419 | 1 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.2681 | 0.2419 | 0.2398 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0456 | 0.0264 | 0.0237 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0212 | 0.0027 | 0.0111 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0345 | 0.0156 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 1.0507 | 1 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 1.0507 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0345 | 0.0156 | 0.0541 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0345 | 0.0156 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.035 | 0.0161 | 0.0134 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 1.0507 | 1 | 1 |
Onchocerca volvulus | 0.2681 | 0.2419 | 1 | |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0345 | 0.0156 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0345 | 0.0156 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.2681 | 0.2419 | 1 |
Schistosoma mansoni | sodium/solute symporter | 0.2681 | 0.2419 | 0.2398 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0345 | 0.0156 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0212 | 0.0027 | 0.0111 |
Schistosoma mansoni | inositol transporter | 1.0507 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 1.0507 | 1 | 1 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.2681 | 0.2419 | 0.2398 |
Schistosoma mansoni | high-affinity choline transporter | 0.2681 | 0.2419 | 0.2398 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.2681 | 0.2419 | 0.2398 |
Brugia malayi | prolyl oligopeptidase family protein | 0.035 | 0.0161 | 0.0559 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.035 | 0.0161 | 0.0134 |
Echinococcus granulosus | solute carrier family 5 | 1.0507 | 1 | 1 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0456 | 0.0264 | 0.0237 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 1.0507 | 1 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0345 | 0.0156 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.2681 | 0.2419 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.035 | 0.0161 | 0.0664 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 1.0507 | 1 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0345 | 0.0156 | 1 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0456 | 0.0264 | 0.0237 |
Brugia malayi | GH02984p | 0.2681 | 0.2419 | 1 |
Brugia malayi | Sodium:solute symporter family protein | 0.2681 | 0.2419 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.035 | 0.0161 | 0.0134 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.248 uM | Inhibition of 6xHis-tagged recombinant human DPP4 expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethylcoumarin by fluorometric assay | ChEMBL. | 24153396 |
IC50 (binding) | = 0.63 uM | Inhibition of 6xHis-tagged recombinant DPP8 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethylcoumarin preincubated for 20 mins followed by Gly-PropNA3 Tos addition measured after 90 mins by fluorometric assay | ChEMBL. | 24153396 |
IC50 (binding) | = 2 uM | Inhibition of 6xHis-tagged recombinant DPP9 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethylcoumarin preincubated for 20 mins followed by Gly-PropNA3 Tos addition measured after 90 mins by fluorometric assay | ChEMBL. | 24153396 |
IC50 (binding) | = 5.44 uM | Inhibition of 6xHis-tagged recombinant DPP7 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Nle-Pro-aminomethylcoumarin after 20 mins by fluorometric assay | ChEMBL. | 24153396 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.