Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Valosin-containing protein | 0.0476 | 0.9457 | 1 |
Brugia malayi | ATPase, AAA family protein | 0.0026 | 0.0000041468 | 0.0000073523 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.03 | 0.5767 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0476 | 0.9457 | 0.9457 |
Toxoplasma gondii | cell division protein CDC48AP | 0.03 | 0.5767 | 0.5767 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0479 | 0.0479 |
Trypanosoma cruzi | vacuolar transport protein 4A, putative | 0.0026 | 0.0000041468 | 0.0000043848 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0476 | 0.9457 | 1 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0502 | 1 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0502 | 1 | 1 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0476 | 0.9457 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.0393 | 0.0393 |
Trypanosoma cruzi | katanin, putative | 0.0026 | 0.0000041468 | 0.0000043848 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0502 | 1 | 1 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0502 | 1 | 0.5 |
Trypanosoma cruzi | katanin, putative | 0.0026 | 0.0000041468 | 0.0000043848 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0208 | 0.3817 | 0.3817 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0331 | 0.0331 |
Trypanosoma cruzi | vacuolar protein sorting-associated protein 4, putative | 0.0026 | 0.0000041468 | 0.0000043848 |
Loa Loa (eye worm) | fidgetin protein | 0.0026 | 0.0000041468 | 0.0000073523 |
Brugia malayi | vesicle-fusing ATPase | 0.0294 | 0.564 | 1 |
Trichomonas vaginalis | 26S protease regulatory subunit S10b, putative | 0.0119 | 0.195 | 0.195 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.564 | 1 |
Trypanosoma cruzi | katanin, putative | 0.0026 | 0.0000041468 | 0.0000043848 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0502 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0331 | 0.0331 |
Trypanosoma cruzi | metalloprotease, putative | 0.0026 | 0.0000041468 | 0.0000043848 |
Loa Loa (eye worm) | VCP protein | 0.0208 | 0.3817 | 0.6768 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0476 | 0.9457 | 1 |
Trypanosoma cruzi | katanin, putative | 0.0026 | 0.0000041468 | 0.0000043848 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0269 | 0.0478 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0294 | 0.564 | 1 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0476 | 0.9457 | 1 |
Trichomonas vaginalis | proteasome-activating nucleotidase, putative | 0.0119 | 0.195 | 0.195 |
Loa Loa (eye worm) | ATPase | 0.0026 | 0.0000041468 | 0.0000073523 |
Toxoplasma gondii | transitional endoplasmic reticulum ATPase, putative | 0.03 | 0.5767 | 0.5767 |
Brugia malayi | valosin containing protein | 0.0294 | 0.564 | 1 |
Trypanosoma cruzi | katanin-like protein, putative | 0.0026 | 0.0000041468 | 0.0000043848 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0479 | 0.0479 |
Brugia malayi | vps4b-prov protein | 0.0026 | 0.0000041468 | 0.0000073523 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.0393 | 0.0393 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0476 | 0.9457 | 1 |
Trypanosoma cruzi | katanin, putative | 0.0026 | 0.0000041468 | 0.0000043848 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.0393 | 0.0697 |
Giardia lamblia | AAA family ATPase | 0.03 | 0.5767 | 1 |
Trypanosoma cruzi | vesicular transport protein (CDC48 homologue), putative | 0.0026 | 0.0000041468 | 0.0000043848 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.0393 | 0.0697 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0208 | 0.3817 | 0.3817 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0476 | 0.9457 | 1 |
Mycobacterium ulcerans | ATPase | 0.03 | 0.5767 | 0.5 |
Brugia malayi | transitional endoplasmic reticulum ATPase TER94, putative | 0.0208 | 0.3817 | 0.6768 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2654 nM | Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysis | ChEMBL. | 24224763 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.