Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 4C, cAMP-specific | References | |
Homo sapiens | phosphodiesterase 4D, cAMP-specific | Starlite/ChEMBL | References |
Homo sapiens | phosphodiesterase 4A, cAMP-specific | References | |
Homo sapiens | phosphodiesterase 4B, cAMP-specific | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | d-amino acid oxidase | 0.4411 | 1 | 1 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0447 | 0.0135 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0447 | 0.0135 | 1 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.4411 | 1 | 0.5 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0447 | 0.0135 | 1 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0447 | 0.0135 | 0.5 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0447 | 0.0135 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0447 | 0.0135 | 0.0135 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.4044 | 0.9085 | 0.5 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0447 | 0.0135 | 0.5 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.4411 | 1 | 0.5 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.0392 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC20 (functional) | = 61 uM | Compound was tested in vitro for positive chronotropic action. | ChEMBL. | 9379444 |
EC50 (functional) | = 0.45 uM | Tested in vitro for tracheal relaxation | ChEMBL. | 9379444 |
IC50 (binding) | = 2.2 uM | Inhibitory activity against Phosphodiesterase 4 from heart. | ChEMBL. | 9379444 |
IC50 (binding) | = 2.2 uM | Inhibitory activity against Phosphodiesterase 4 from heart. | ChEMBL. | 9379444 |
IC50 (binding) | = 149 uM | Inhibitory activity against PDE1 from cerebral cortex | ChEMBL. | 9379444 |
IC50 (binding) | = 149 uM | Inhibitory activity against PDE1 from cerebral cortex | ChEMBL. | 9379444 |
IC50 (binding) | > 300 uM | Inhibitory activity against Phosphodiesterase 3 from heart. | ChEMBL. | 9379444 |
IC50 (binding) | > 300 uM | Inhibitory activity against Phosphodiesterase 3 from heart. | ChEMBL. | 9379444 |
pA2 (functional) | = 6.23 | Negative inotropic response to adenosine in guinea pig left atrium | ChEMBL. | 9379444 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.