Detailed information for compound 1825094

Basic information

Technical information
  • TDR Targets ID: 1825094
  • Name: N'-(4-aminophenyl)sulfonylpyridine-4-carbohyd razide
  • MW: 292.314 | Formula: C12H12N4O3S
  • H donors: 3 H acceptors: 4 LogP: 0.3 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc(cc1)S(=O)(=O)NNC(=O)c1ccncc1
  • InChi: 1S/C12H12N4O3S/c13-10-1-3-11(4-2-10)20(18,19)16-15-12(17)9-5-7-14-8-6-9/h1-8,16H,13H2,(H,15,17)
  • InChiKey: MPOSWSGTQFFLLR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-(4-aminophenyl)sulfonyl-4-pyridinecarbohydrazide
  • N'-(4-aminophenyl)sulfonylisonicotinohydrazide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible D-alpha-D-heptose-7-phosphate kinase HddA 0.0036 0.0759 0.2026
Echinococcus multilocularis caspase 2 0.002 0.016 0.016
Trypanosoma brucei galactokinase-like protein, putative 0.0079 0.23 1
Mycobacterium tuberculosis Probable galactokinase GalK (galactose kinase) 0.0119 0.3745 1
Echinococcus granulosus galactokinase 0.0119 0.3745 0.3745
Onchocerca volvulus Cell death protein 3 homolog 0.002 0.016 0.0973
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0061 0.1644 0.1644
Entamoeba histolytica galactokinase, putative 0.0119 0.3745 0.5
Trypanosoma brucei phosphomevalonate kinase protein, putative 0.0036 0.0759 0.33
Echinococcus granulosus apoptotic protease activating factor 1 0.002 0.016 0.016
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.016 0.0973
Echinococcus granulosus Mevalonate galactokinase 0.0036 0.0759 0.0759
Brugia malayi Cell death protein 3 precursor 0.002 0.016 0.0973
Trichomonas vaginalis galactokinase, putative 0.0021 0.02 0.1387
Loa Loa (eye worm) hypothetical protein 0.0036 0.0759 0.4616
Echinococcus multilocularis Mevalonate galactokinase 0.0036 0.0759 0.0759
Chlamydia trachomatis 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0015 0 0.5
Onchocerca volvulus Deterin homolog 0.0061 0.1644 1
Mycobacterium leprae Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) 0.0036 0.0759 1
Toxoplasma gondii GHMP kinase, N-terminal domain-containing protein 0.0055 0.1445 1
Schistosoma mansoni caspase-7 (C14 family) 0.002 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0061 0.1644 1
Trypanosoma cruzi galactokinase, putative 0.0119 0.3745 1
Brugia malayi mevalonate kinase family protein 0.0036 0.0759 0.4616
Mycobacterium ulcerans galactokinase 0.0119 0.3745 1
Echinococcus multilocularis inhibitor of apoptosis protein 0.0061 0.1644 0.1644
Trichomonas vaginalis galactokinase, putative 0.0055 0.1445 1
Echinococcus multilocularis galactokinase 0.0119 0.3745 0.3745
Echinococcus granulosus caspase 2 0.002 0.016 0.016
Schistosoma mansoni hypothetical protein 0.0061 0.1644 0.1644
Schistosoma mansoni mevalonate kinase 0.0036 0.0759 0.0759
Trichomonas vaginalis galactokinase, putative 0.0055 0.1445 1
Trypanosoma cruzi galactokinase-like protein, putative 0.0103 0.3186 0.8509
Mycobacterium ulcerans homoserine kinase 0.0036 0.0759 0.2026
Loa Loa (eye worm) hypothetical protein 0.0061 0.1644 1
Mycobacterium ulcerans phosphomevalonate kinase 0.0036 0.0759 0.2026
Onchocerca volvulus 0.002 0.016 0.0973
Mycobacterium ulcerans 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0036 0.0759 0.2026
Mycobacterium ulcerans mevalonate kinase, Erg12 0.0036 0.0759 0.2026
Loa Loa (eye worm) galactokinase 0.0055 0.1445 0.879
Leishmania major mevalonate kinase, putative 0.0036 0.0759 0.2026
Trichomonas vaginalis galactokinase, putative 0.0055 0.1445 1
Leishmania major galactokinase-like protein 0.0119 0.3745 1
Echinococcus multilocularis N acetylgalactosamine kinase 0.0055 0.1445 0.1445
Schistosoma mansoni inhibitor of apoptosis protein 0.0061 0.1644 0.1644
Trypanosoma cruzi mevalonate kinase, putative 0.0036 0.0759 0.2026
Trypanosoma cruzi fucose kinase, putative 0.0021 0.02 0.0535
Trypanosoma brucei homoserine kinase 0.0036 0.0759 0.33
Trypanosoma cruzi galactokinase, putative 0.0103 0.3186 0.8509
Treponema pallidum galactokinase 0.0103 0.3186 1
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0061 0.1644 0.1644
Trichomonas vaginalis galactokinase, putative 0.0055 0.1445 1
Wolbachia endosymbiont of Brugia malayi 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0036 0.0759 0.5
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0061 0.1644 1
Echinococcus granulosus N acetylgalactosamine kinase 0.0055 0.1445 0.1445
Echinococcus granulosus inhibitor of apoptosis protein 0.0061 0.1644 0.1644
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0061 0.1644 1
Brugia malayi hypothetical protein 0.002 0.016 0.0973
Leishmania major homoserine kinase, putative 0.0036 0.0759 0.2026
Loa Loa (eye worm) hypothetical protein 0.002 0.016 0.0973
Schistosoma mansoni hypothetical protein 0.002 0.016 0.016
Schistosoma mansoni biogenic amine (5HT) receptor 0.0291 1 1
Brugia malayi galactokinase family protein 0.0055 0.1445 0.879
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0061 0.1644 0.1644
Leishmania major phosphomevalonate kinase protein, putative 0.0036 0.0759 0.2026
Trypanosoma cruzi homoserine kinase 0.0036 0.0759 0.2026
Trypanosoma brucei mevalonate kinase, putative 0.0036 0.0759 0.33
Trypanosoma cruzi fucose kinase, putative 0.0021 0.02 0.0535
Giardia lamblia Mevalonate kinase 0.0036 0.0759 1
Trypanosoma cruzi galactokinase, putative 0.0119 0.3745 1
Trypanosoma cruzi homoserine kinase 0.0036 0.0759 0.2026
Schistosoma mansoni galactokinase 0.0055 0.1445 0.1445
Onchocerca volvulus 0.0061 0.1644 1
Echinococcus multilocularis apoptotic protease activating factor 1 0.002 0.016 0.016

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 600 ug ml-1 Antitubercular activity against Mycobacterium tuberculosis ChEMBL. 24246731
MIC (functional) = 2052.615 uM Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by BACTEC 960 assay ChEMBL. 24836065

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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