Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 protease | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | Get druggable targets OG5_131408 | All targets in OG5_131408 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0504 | 0.2486 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0504 | 0.2486 | 0.5 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0504 | 0.2486 | 0.5 |
Mycobacterium tuberculosis | 4,9-DHSA hydrolase | 0.1282 | 0.8197 | 1 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0504 | 0.2486 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0504 | 0.2486 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0504 | 0.2486 | 0.2977 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.1373 | 0.8867 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0504 | 0.2486 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0504 | 0.2486 | 0.5 |
Plasmodium falciparum | esterase, putative | 0.0504 | 0.2486 | 1 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0278 | 0.0823 | 0.0823 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0504 | 0.2486 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0504 | 0.2486 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1373 | 0.8867 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.1373 | 0.8867 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.1373 | 0.8867 | 0.8867 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.1373 | 0.8867 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0504 | 0.2486 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0504 | 0.2486 | 0.5 |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.1303 | 0.835 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0504 | 0.2486 | 0.5 |
Mycobacterium ulcerans | lysophospholipase | 0.0504 | 0.2486 | 0.2977 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0504 | 0.2486 | 0.5 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0166 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0504 | 0.2486 | 0.5 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0504 | 0.2486 | 0.3032 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.1373 | 0.8867 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0166 | 0 | 0.5 |
Leishmania major | monoglyceride lipase, putative | 0.0504 | 0.2486 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0504 | 0.2486 | 0.5 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0504 | 0.2486 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0504 | 0.2486 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0166 | 0 | 0.5 |
Schistosoma mansoni | amidase | 0.1373 | 0.8867 | 0.8867 |
Brugia malayi | amidase | 0.1373 | 0.8867 | 1 |
Plasmodium vivax | PST-A protein | 0.0504 | 0.2486 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (binding) | = 0.118 uM | In vivo antiviral activity (IC50) against HIV-1 protease. | ChEMBL. | 8759643 |
ED50 (binding) | = 0.118 uM | In vivo antiviral activity (IC50) against HIV-1 protease. | ChEMBL. | 8759643 |
ED90 (binding) | = 1 uM | In vivo for antiviral activity (ED90) against HIV-1 protease. | ChEMBL. | 8759643 |
ED90 (binding) | = 1 uM | In vivo for antiviral activity (ED90) against HIV-1 protease. | ChEMBL. | 8759643 |
IC50 (binding) | = 31 nM | In vivo antiviral activity (IC50) against HIV-1 protease. | ChEMBL. | 8759643 |
IC50 (binding) | = 31 nM | In vivo antiviral activity (IC50) against HIV-1 protease. | ChEMBL. | 8759643 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.