Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | endonuclease G, putative | 0.0294 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0489 | 0.2563 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0489 | 0.2563 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0412 | 0.1553 | 0.6061 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0489 | 0.2563 | 0.2563 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0294 | 0 | 0.5 |
Onchocerca volvulus | 0.1057 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.1057 | 1 | 1 |
Echinococcus multilocularis | ectonucleotide | 0.0412 | 0.1553 | 0.6061 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0294 | 0 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0294 | 0 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0489 | 0.2563 | 0.2563 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0489 | 0.2563 | 0.2563 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.2563 | 0.1195 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.1057 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0489 | 0.2563 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0489 | 0.2563 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0489 | 0.2563 | 0.2563 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0489 | 0.2563 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0489 | 0.2563 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0489 | 0.2563 | 1 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0294 | 0 | 0.5 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0294 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0489 | 0.2563 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0412 | 0.1553 | 0.6061 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0489 | 0.2563 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0489 | 0.2563 | 0.2563 |
Echinococcus granulosus | ectonucleotide | 0.0412 | 0.1553 | 0.6061 |
Trypanosoma cruzi | endonuclease G, putative | 0.0294 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.2563 | 0.1195 |
Trypanosoma cruzi | endonuclease G, putative | 0.0294 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0489 | 0.2563 | 1 |
Leishmania major | endonuclease G, putative | 0.0294 | 0 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0294 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.2563 | 0.1195 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0489 | 0.2563 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 6 | Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assay | ChEMBL. | 24161834 |
Ki (functional) | = 8 | Antagonist activity at human histamine H3 receptor expressed in CHOK1 cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay | ChEMBL. | 24161834 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.