Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | G protein-coupled receptor kinase 5 | Starlite/ChEMBL | References |
Homo sapiens | adrenergic, beta, receptor kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0128 | 0.6649 | 0.6649 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.014 | 0.7673 | 0.7673 |
Echinococcus granulosus | carbonic anhydrase II | 0.0108 | 0.4913 | 0.6404 |
Plasmodium falciparum | carbonic anhydrase | 0.0051 | 0 | 0.5 |
Echinococcus granulosus | G protein coupled receptor kinase 1 | 0.0101 | 0.4321 | 0.5632 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0108 | 0.4913 | 0.4913 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0128 | 0.6649 | 0.8665 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.014 | 0.7673 | 0.7673 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.014 | 0.7673 | 0.7673 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0128 | 0.6649 | 0.6649 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0108 | 0.4913 | 0.4913 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.014 | 0.7673 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0108 | 0.4913 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0108 | 0.4913 | 0.4913 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.014 | 0.7673 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0108 | 0.4913 | 0.4913 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0167 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0108 | 0.4913 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0108 | 0.4913 | 0.6404 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0167 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0128 | 0.6649 | 0.6649 |
Leishmania major | carbonic anhydrase-like protein | 0.0108 | 0.4913 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0108 | 0.4913 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0051 | 0 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0108 | 0.4913 | 0.4913 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0128 | 0.6649 | 0.8665 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0108 | 0.4913 | 0.4913 |
Echinococcus multilocularis | G protein coupled receptor kinase 1 | 0.0101 | 0.4321 | 0.5632 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.5 uM | Inhibition of GRK-5 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRET assay | ChEMBL. | 24210504 |
IC50 (binding) | > 10 uM | Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRET assay | ChEMBL. | 24210504 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.