Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.0446 | 1 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14, putative | 0.0077 | 0.1436 | 1 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0077 | 0.1436 | 0.5 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0077 | 0.1436 | 1 |
Brugia malayi | Carboxypeptidase A2 precursor | 0.0077 | 0.1436 | 1 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0077 | 0.1436 | 0.1745 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1436 | 0.1745 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1436 | 0.1745 |
Trypanosoma brucei | metallo-peptidase, Clan MC, Family M14, putative | 0.0077 | 0.1436 | 1 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0077 | 0.1436 | 1 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0077 | 0.1436 | 1 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0077 | 0.1436 | 0.1745 |
Toxoplasma gondii | zinc carboxypeptidase, putative | 0.0077 | 0.1436 | 0.5 |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0446 | 1 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14 | 0.0077 | 0.1436 | 1 |
Onchocerca volvulus | 0.0446 | 1 | 1 | |
Trypanosoma brucei | Carboxypeptidase-like protein | 0.0077 | 0.1436 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14, putative | 0.0077 | 0.1436 | 1 |
Trypanosoma cruzi | zinc carboxypeptidase, putative | 0.0077 | 0.1436 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1436 | 0.1745 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0077 | 0.1436 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1436 | 0.1745 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0077 | 0.1436 | 0.5 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0077 | 0.1436 | 1 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0077 | 0.1436 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1436 | 0.1745 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0077 | 0.1436 | 0.5 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0077 | 0.1436 | 0.5 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0077 | 0.1436 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1436 | 0.1745 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0077 | 0.1436 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MC, Family M14, putative | 0.0077 | 0.1436 | 1 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0077 | 0.1436 | 0.5 |
Onchocerca volvulus | 0.0446 | 1 | 1 | |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | subfamily M14A unassigned peptidase | 0.0446 | 1 | 1 |
Onchocerca volvulus | 0.0446 | 1 | 1 | |
Toxoplasma gondii | zinc carboxypeptidase superfamily protein | 0.0077 | 0.1436 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.8225 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1436 | 0.1745 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0077 | 0.1436 | 1 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0077 | 0.1436 | 1 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0077 | 0.1436 | 0.5 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0077 | 0.1436 | 1 |
Toxoplasma gondii | zinc carboxypeptidase superfamily protein | 0.0077 | 0.1436 | 0.5 |
Onchocerca volvulus | 0.0446 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1436 | 0.1745 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0077 | 0.1436 | 0.5 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0077 | 0.1436 | 0.5 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0077 | 0.1436 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0077 | 0.1436 | 0.5 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0077 | 0.1436 | 0.1745 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0077 | 0.1436 | 0.5 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0077 | 0.1436 | 1 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0077 | 0.1436 | 0.5 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0077 | 0.1436 | 0.1745 |
Toxoplasma gondii | flagellar/basal body protein | 0.0077 | 0.1436 | 0.5 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0077 | 0.1436 | 0.5 |
Trypanosoma cruzi | Carboxypeptidase-like protein | 0.0077 | 0.1436 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1436 | 0.1745 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0077 | 0.1436 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1436 | 0.1745 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
pD2 (functional) | 0 | In vivo activity of the compound against gastric secretion in conscious cat; not active | ChEMBL. | 1507209 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.