Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0555 | 0.6263 | 0.8037 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0383 | 0.41 | 0.48 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0555 | 0.6263 | 1 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0514 | 0.5751 | 0.6803 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0555 | 0.6263 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0364 | 0.3852 | 0.4205 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0364 | 0.3852 | 0.4205 |
Echinococcus multilocularis | carbonic anhydrase | 0.0291 | 0.2928 | 0.2928 |
Echinococcus granulosus | carbonic anhydrase | 0.0291 | 0.2928 | 0.2928 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0364 | 0.3852 | 0.4205 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0555 | 0.6263 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0291 | 0.2928 | 0.4137 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0619 | 0.7077 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0619 | 0.7077 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0291 | 0.2928 | 0.2928 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0555 | 0.6263 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0619 | 0.7077 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0619 | 0.7077 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0555 | 0.6263 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0619 | 0.7077 | 0.7077 |
Echinococcus multilocularis | carbonic anhydrase | 0.0291 | 0.2928 | 0.2928 |
Echinococcus granulosus | carbonic anhydrase | 0.0291 | 0.2928 | 0.2928 |
Plasmodium falciparum | carbonic anhydrase | 0.0291 | 0.2928 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0383 | 0.41 | 0.48 |
Echinococcus granulosus | carbonic anhydrase | 0.0291 | 0.2928 | 0.2928 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0514 | 0.5751 | 0.8126 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0514 | 0.5751 | 0.6803 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0619 | 0.7077 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0364 | 0.3852 | 0.4205 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.085 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0291 | 0.2928 | 0.4137 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.085 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0291 | 0.2928 | 0.4137 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0619 | 0.7077 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0364 | 0.3852 | 0.4205 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0291 | 0.2928 | 0.4137 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0619 | 0.7077 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0364 | 0.3852 | 0.4205 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0364 | 0.3852 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0555 | 0.6263 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0619 | 0.7077 | 0.5 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0555 | 0.6263 | 0.8037 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0619 | 0.7077 | 0.7077 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0619 | 0.7077 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0364 | 0.3852 | 0.4205 |
Toxoplasma gondii | hypothetical protein | 0.0291 | 0.2928 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0291 | 0.2928 | 0.4137 |
Leishmania major | carbonic anhydrase-like protein | 0.0619 | 0.7077 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antibiofilm activity against Candida albicans SC5314 at 8 to 60 ug/ml after 24 hrs by crystal violet staining method relative to control | ChEMBL. | 23974017 | |
Activity (functional) | Induction of degradation of Candida albicans SC5314 biofilm at 20 ug/ml after 24 hrs by XTT assay relative to vehicle-treated control | ChEMBL. | 23974017 | |
MIC100 (functional) | = 20 ug ml-1 | Antimicrobial activity against Candida albicans SC5314 after 24 hrs by microbroth dilution method | ChEMBL. | 23974017 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.