Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TANK-binding kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_132247 | All targets in OG5_132247 | |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_132247 | All targets in OG5_132247 |
Loa Loa (eye worm) | IKK protein kinase | Get druggable targets OG5_132247 | All targets in OG5_132247 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.2586 | 1 | 1 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0411 | 0 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0411 | 0 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0411 | 0 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.2586 | 1 | 1 |
Onchocerca volvulus | 0.0556 | 0.0666 | 0.0666 | |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.2586 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0411 | 0 | 0.5 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0411 | 0 | 0.5 |
Leishmania major | glutaminyl cyclase, putative | 0.0411 | 0 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0411 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0411 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0411 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0411 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0411 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0411 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0411 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0411 | 0 | 0.5 |
Loa Loa (eye worm) | IKK protein kinase | 0.0556 | 0.0666 | 0.0666 |
Loa Loa (eye worm) | hypothetical protein | 0.2586 | 1 | 1 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.2586 | 1 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0411 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0556 | 0.0666 | 0.0666 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.8 uM | Inhibition of recombinant full-length TBK1 (unknown origin) using CK1tide as substrate by microfluidic mobility shift assay | ChEMBL. | 24462666 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.