Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 633 aa | 507 aa | 23.9 % |
Onchocerca volvulus | Acetylcholinesterase | 633 aa | 648 aa | 25.3 % | |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 633 aa | 690 aa | 31.7 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 633 aa | 549 aa | 30.4 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 620 aa | 28.4 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 517 aa | 25.1 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 633 aa | 690 aa | 32.3 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 597 aa | 25.1 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 633 aa | 622 aa | 24.9 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 576 aa | 23.4 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 633 aa | 576 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | DNA polymerase delta catalytic subunit | 0.0159 | 1 | 1 |
Plasmodium falciparum | DNA polymerase delta catalytic subunit | 0.0159 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.2742 | 0.2742 |
Trichomonas vaginalis | DNA polymerase zeta catalytic subunit, putative | 0.0159 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.2742 | 0.2742 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.2742 | 0.2742 |
Entamoeba histolytica | DNA polymerase delta catalytic subunit, putative | 0.0159 | 1 | 0.5 |
Giardia lamblia | DNA polymerase delta, catalytic subunit | 0.0159 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.2742 | 0.2742 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.2742 | 0.2742 |
Loa Loa (eye worm) | DNA-directed DNA polymerase III | 0.0159 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.2742 | 0.2742 |
Toxoplasma gondii | DNA polymerase | 0.0159 | 1 | 1 |
Trypanosoma brucei | DNA polymerase delta catalytic subunit, putative | 0.0159 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.2742 | 0.2742 |
Onchocerca volvulus | DNA polymerase delta catalytic subunit homolog | 0.0159 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.2742 | 0.2742 |
Schistosoma mansoni | DNA polymerase delta catalytic subunit | 0.0159 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase delta catalytic subunit, putative | 0.013 | 0.7266 | 0.7266 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.2742 | 0.2742 |
Plasmodium vivax | DNA polymerase delta catalytic subunit, putative | 0.0159 | 1 | 1 |
Echinococcus multilocularis | DNA polymerase delta catalytic subunit | 0.0159 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.2742 | 0.2742 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.2742 | 0.2742 |
Leishmania major | DNA polymerase delta catalytic subunit, putative | 0.0159 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.2742 | 0.2742 |
Trypanosoma cruzi | DNA polymerase delta catalytic subunit, putative | 0.0159 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.2742 | 0.2742 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.4 uM | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured after 5 mins by Ellman's method | ChEMBL. | 24530494 |
IC50 (binding) | > 100 uM | Inhibition of human recombinant MAO-B using tyramine as substrate preincubated for 30 mins followed by substrate addition measured for 1 hr by fluorometric assay | ChEMBL. | 24530494 |
IC50 (binding) | > 100 uM | Inhibition of human recombinant MAO-A using tyramine as substrate preincubated for 30 mins followed by substrate addition measured for 1 hr by fluorometric assay | ChEMBL. | 24530494 |
IC50 (binding) | > 100 uM | Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured after 25 mins by Ellman's method | ChEMBL. | 24530494 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.