Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | monoamine oxidase A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 633 aa | 507 aa | 23.9 % |
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase A | 527 aa | 474 aa | 22.4 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 633 aa | 622 aa | 24.9 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 517 aa | 25.1 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 633 aa | 690 aa | 31.7 % |
Onchocerca volvulus | Acetylcholinesterase | 633 aa | 648 aa | 25.3 % | |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 633 aa | 576 aa | 28.8 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 633 aa | 549 aa | 30.4 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 633 aa | 690 aa | 32.3 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 620 aa | 28.4 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 597 aa | 25.1 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 576 aa | 23.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.7615 | 1 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0333 | 0 | 0.5 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.7615 | 1 | 1 |
Onchocerca volvulus | 0.1943 | 0.2211 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.1943 | 0.2211 | 0.5 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.1943 | 0.2211 | 0.5 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.7615 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 0.7615 | 1 | 1 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.7615 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 0.7615 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 0.7615 | 1 | 1 |
Echinococcus granulosus | solute carrier family 5 | 0.7615 | 1 | 1 |
Brugia malayi | GH02984p | 0.1943 | 0.2211 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 0.0035 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1943 | 0.2211 | 0.5 |
Brugia malayi | Sodium:solute symporter family protein | 0.1943 | 0.2211 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 0.0035 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.24 uM | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured after 5 mins by Ellman's method | ChEMBL. | 24530494 |
IC50 (binding) | = 4.26 uM | Inhibition of human recombinant MAO-A using tyramine as substrate preincubated for 30 mins followed by substrate addition measured for 1 hr by fluorometric assay | ChEMBL. | 24530494 |
IC50 (binding) | > 100 uM | Inhibition of human recombinant MAO-B using tyramine as substrate preincubated for 30 mins followed by substrate addition measured for 1 hr by fluorometric assay | ChEMBL. | 24530494 |
IC50 (binding) | > 100 uM | Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured after 25 mins by Ellman's method | ChEMBL. | 24530494 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.