TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 242.276 | Formula: C13H14N4O
H donors: 0 H acceptors: 3 LogP: 0.37 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(/C=C/c1nccn1C)/C=C/c1nccn1C
InChi: 1S/C13H14N4O/c1-16-9-7-14-12(16)5-3-11(18)4-6-13-15-8-10-17(13)2/h3-10H,1-2H3/b5-3+,6-4+
InChiKey: YVCZXGWQOMQJBS-GGWOSOGESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0002	0.0099	0.0714
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0012	0.0836	0.5796
Brugia malayi	Patatin-like phospholipase family protein	0.0002	0.0085	0.0084
Trypanosoma brucei	Ankyrin repeats (many copies), putative	0.0002	0.0085	0.0000007409
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	unc-44 ankyrins, putative	0.0002	0.0099	0.0714
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0019	0.1382	0.1308
Brugia malayi	WGR domain containing protein	0.0019	0.1382	0.1394
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Trichomonas vaginalis	serine/threonine-protein kinase ripk4, putative	0.0002	0.0086	0.0622
Echinococcus granulosus	Sterile alpha motif SAM	0.0012	0.0836	0.0759
Echinococcus granulosus	Ankyrin	0.0002	0.0099	0.0014
Echinococcus multilocularis	liprin alpha 2	0.0012	0.0836	0.0836
Schistosoma mansoni	hypothetical protein	0.0012	0.0836	0.0758
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0086	0.0622
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Trichomonas vaginalis	26S proteasome non-ATPase regulatory subunit, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.1382	1
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Giardia lamblia	Kinase, NEK	0.0002	0.0099	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0836	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0836	0.0833
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin, putative	0.0002	0.0086	0.0622
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0086	0.0622
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0086	0.0622
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0099	0.0714
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0836	0.0833
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0099	0.0714
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0001	0.0001	0.0011
Trichomonas vaginalis	sex-determining protein fem-1, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Trypanosoma cruzi	ankyrin repeat protein, putative	0.0002	0.0085	0.0000007409
Schistosoma mansoni	lip-related protein (liprin) alpha	0.0012	0.0836	0.0758
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0001	0.0001	0.0011
Echinococcus multilocularis	SAM domain containing protein	0.0012	0.0836	0.0836
Echinococcus multilocularis	E3 ubiquitin protein ligase mib1	0.0002	0.0099	0.0097
Trichomonas vaginalis	serine/threonine-protein kinase ripk4, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	multiple ankyrin repeats single kh domain protein, putative	0.0002	0.0099	0.0714
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0001	0.0001	0.0011
Echinococcus multilocularis	sterile alpha and tir motif containing protein	0.0012	0.0836	0.0836
Trichomonas vaginalis	fetal globin-inducing factor, putative	0.0002	0.0085	0.0612
Brugia malayi	sterile alpha and TIR motif containing protein 1 isoform a	0.0012	0.0836	0.0844
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Giardia lamblia	Kinase, NEK	0.0002	0.0099	1
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.1382	1
Trichomonas vaginalis	E3 ubiquitin protein ligase, putative	0.0002	0.0086	0.0622
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	rolling pebbles, putative	0.0002	0.0085	0.0612
Entamoeba histolytica	zinc finger protein, putative	0.0019	0.1382	1
Schistosoma mansoni	hypothetical protein	0.0012	0.0836	0.0758
Trichomonas vaginalis	multiple ankyrin repeats single kh domain protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.1382	1
Trichomonas vaginalis	ion channel nompc, putative	0.0002	0.0086	0.0622
Entamoeba histolytica	hypothetical protein	0.0019	0.1382	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Echinococcus multilocularis	ankyrin repeat domain containing protein 6	0.0002	0.0085	0.0083
Trichomonas vaginalis	nf kappa B inhibitor I-kappa-B, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.1382	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0124	0.0896
Brugia malayi	hypothetical protein	0.0012	0.0836	0.0844
Giardia lamblia	Kinase, NEK-frag	0.0002	0.0085	0.0001
Trichomonas vaginalis	ankyrin repeat-rich membrane-spanning protein, putative	0.0002	0.0086	0.0622
Giardia lamblia	Kinase, NEK	0.0002	0.0085	0.0001
Trichomonas vaginalis	ankyrin, putative	0.0002	0.01	0.0724
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0019	0.1382	1
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0002	0.0099	0.0714
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Brugia malayi	glutaminase DH11.1	0.0002	0.0085	0.0084
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0099	0.0714
Trichomonas vaginalis	protein phosphatase 1 regulatory subunit 12B, putative	0.0002	0.0086	0.0622
Schistosoma mansoni	ankyrin 23/unc44	0.0002	0.0099	0.0014
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0086	0.0622
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Brugia malayi	Leucine Rich Repeat family protein	0.0002	0.0085	0.0084
Brugia malayi	Patatin-like phospholipase family protein	0.0002	0.0099	0.0098
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0086	0.0622
Onchocerca volvulus		0.0012	0.0836	0.0847
Trichomonas vaginalis	tankyrase, putative	0.0001	0.0001	0.0011
Schistosoma mansoni	lar interacting protein (lip)-related protein	0.0012	0.0836	0.0758
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Entamoeba histolytica	hypothetical protein	0.0019	0.1382	1
Trichomonas vaginalis	inversin, putative	0.0002	0.0086	0.0622
Loa Loa (eye worm)	hypothetical protein	0.0002	0.01	0.0017
Trichomonas vaginalis	ankyrin repeat and sam domain-containing protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0002	0.0086	0.0622
Trichomonas vaginalis	sex-determining protein fem-1, putative	0.0002	0.0085	0.0612
Entamoeba histolytica	ankyrin repeat protein, putative	0.0002	0.0085	0.0000007409
Trypanosoma cruzi	palmitoyl acyltransferase 1, putative	0.0002	0.0099	0.0109
Plasmodium falciparum	tyrosine kinase-like protein	0.0012	0.0836	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.1382	1
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0003	0.0138	0.0998
Trichomonas vaginalis	tankyrase, putative	0.0002	0.0086	0.0622
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	c2h2 zinc finger protein, putative	0.0012	0.0836	0.6053
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Echinococcus multilocularis	Ankyrin	0.0002	0.0085	0.0083
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0836	0.6053
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Schistosoma mansoni	phospholipase	0.0002	0.0085	0.000000096934
Giardia lamblia	Ankyrin 1	0.0002	0.0085	0.0001
Echinococcus granulosus	poly ADP ribose polymerase 1	0.0019	0.1382	0.131
Echinococcus multilocularis	Ankyrin	0.0002	0.01	0.0099
Trichomonas vaginalis	ankyrin, putative	0.0002	0.0099	0.0714
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Trichomonas vaginalis	ion channel nompc, putative	0.0002	0.0099	0.0714
Echinococcus granulosus	26S proteasome non ATPase regulatory subunit 10	0.0002	0.0086	0.0001
Giardia lamblia	Kinase, NEK	0.0002	0.0085	0.0001
Giardia lamblia	Protein 21.1	0.0002	0.0085	0.0001
Trichomonas vaginalis	mind bomb, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin, putative	0.0002	0.0086	0.0622
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0012	0.0836	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.1382	1
Schistosoma mansoni	26S proteasome subunit	0.0002	0.0085	0.000000096934
Echinococcus multilocularis	26S proteasome non ATPase regulatory subunit 10	0.0002	0.0086	0.0085
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Schistosoma mansoni	ga binding protein beta chain (transcription factor e4tf1-47)	0.0002	0.0085	0.000000096934
Trypanosoma cruzi	palmitoyl acyltransferase 1, putative	0.0002	0.0099	0.0109
Trichomonas vaginalis	ion channel nompc, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Echinococcus granulosus	E3 ubiquitin protein ligase mib1	0.0002	0.0099	0.0014
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Brugia malayi	hypothetical protein	0.0012	0.0836	0.0844
Echinococcus granulosus	poly adp ribose polymerase 2	0.0019	0.1382	0.131
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	2-5A-dependent ribonuclease, putative	0.0002	0.0099	0.0714
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Entamoeba histolytica	hypothetical protein	0.0019	0.1382	1
Trichomonas vaginalis	ankyrin, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0086	0.0622
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.0019	0.1382	0.1437
Trypanosoma brucei	poly(adp-ribose) polymerase	0.0019	0.1382	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.01	0.0724
Trypanosoma brucei	palmitoyl acyltransferase 1, putative	0.0002	0.0099	0.0109
Schistosoma mansoni	hypothetical protein	0.0012	0.0836	0.0758
Trichomonas vaginalis	TKL family protein kinase	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0099	0.0714
Echinococcus multilocularis	poly (ADP ribose) polymerase	0.0019	0.1382	0.1382
Onchocerca volvulus	Tankyrase homolog	0.0122	0.896	1
Loa Loa (eye worm)	toll and interleukin 1 receptor domain-containing protein isoform f	0.0012	0.0836	0.0833
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.1382	1
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.0019	0.1382	0.1382
Trichomonas vaginalis	protein phosphatase 1 regulatory subunit 12B, putative	0.0002	0.0085	0.0612
Brugia malayi	Tnks protein	0.0135	0.99	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0001	0.0001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0836	0.0833
Brugia malayi	Neurabin protein 1	0.0012	0.0836	0.0844
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0002	0.0099	0.0714
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.1382	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0085	0.00000010649
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0086	0.0622
Echinococcus granulosus	tankyrase	0.0136	0.9986	1
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.0019	0.1382	0.1382
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0001	0.0001	0.0011
Trichomonas vaginalis	homeobox-containing protein wariai, putative	0.0002	0.0085	0.0612
Echinococcus multilocularis	liprin beta 1	0.0012	0.0836	0.0836
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Loa Loa (eye worm)	tnks protein	0.0124	0.911	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0002	0.0122	0.0885
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.0019	0.1382	1
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0085	0.00000010649
Trichomonas vaginalis	hypothetical protein	0.0002	0.0085	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat domain-containing protein, putative	0.0002	0.0086	0.0622
Loa Loa (eye worm)	hypothetical protein	0.0019	0.1382	0.1437
Trichomonas vaginalis	serine/threonine-protein kinase ripk4, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0001	0.0001	0.0011
Echinococcus granulosus	Ankyrin	0.0002	0.0085	0.000000097072
Trichomonas vaginalis	unc-44 ankyrins, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Plasmodium falciparum	protein kinase, putative	0.0012	0.0836	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Schistosoma mansoni	sarm1	0.0012	0.0836	0.0758
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0099	0.0714
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0002	0.0099	0.0714
Loa Loa (eye worm)	Notch2	0.0002	0.0086	0.0002
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0019	0.1382	0.1308
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0085	0.00000010649
Trichomonas vaginalis	ankyrin repeat-cotaining protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	2-5A-dependent ribonuclease, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.1382	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	cask-interacting protein (caskin) 1,2, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	cortactin-binding protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	ankyrin repeat-rich membrane-spanning protein, putative	0.0002	0.0085	0.0612
Giardia lamblia	Protein 21.1	0.0002	0.0085	0.0001
Leishmania major	huntingtin interacting protein (HIP), putative	0.0002	0.0099	1
Echinococcus granulosus	liprin beta 1	0.0012	0.0836	0.0759
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0836	0.0833
Echinococcus granulosus	stromal interaction molecule 1	0.0012	0.0836	0.0759
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0836	0.6053
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0019	0.1382	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	unc-44 ankyrins, putative	0.0002	0.0099	0.0714
Entamoeba histolytica	hypothetical protein	0.0019	0.1382	1
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0836	0.6053
Trichomonas vaginalis	fibronectin type 3 and ankyrin repeat domains, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	ion channel nompc, putative	0.0002	0.0086	0.0622
Echinococcus granulosus	SAM domain containing protein	0.0012	0.0836	0.0759
Echinococcus multilocularis	stromal interaction molecule 1	0.0012	0.0836	0.0836
Echinococcus granulosus	liprin alpha 2	0.0012	0.0836	0.0759
Trichomonas vaginalis	fetal globin-inducing factor, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Brugia malayi	WGR domain containing protein	0.0019	0.1382	0.1394
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0019	0.1382	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0099	0.0714
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0836	0.6053
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0001	0.0001	0.0011
Onchocerca volvulus		0.0012	0.0836	0.0847
Echinococcus multilocularis	tankyrase	0.0136	0.9986	1
Trichomonas vaginalis	2-5A-dependent ribonuclease, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	hypothetical protein	0.0002	0.0085	0.0612
Trichomonas vaginalis	centaurin beta, putative	0.0002	0.0085	0.0612
Brugia malayi	Uncoordinated protein 44	0.0002	0.0086	0.0085
Trichomonas vaginalis	protein phosphatase 1 regulatory subunit 12C, putative	0.0002	0.0099	0.0714
Echinococcus multilocularis	Ankyrin	0.0002	0.0085	0.0083
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0099	0.0714
Loa Loa (eye worm)	hypothetical protein	0.0103	0.754	0.826
Trichomonas vaginalis	ion channel nompc, putative	0.0002	0.0085	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.0085	0.0612
Brugia malayi	coiled-coil like protein 1	0.0012	0.0836	0.0844
Schistosoma mansoni	hypothetical protein	0.0012	0.0836	0.0758
Brugia malayi	Liprin-alpha 2	0.0012	0.0836	0.0844
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0085	0.00000010649
Echinococcus granulosus	sterile alpha and tir motif containing protein	0.0012	0.0836	0.0759

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.11 uM	Cytotoxicity against human PC3 cells after 5 days by trypan blue exclusion assay	ChEMBL.	24531225

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	24531225

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3127993

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1826639