Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | G protein-coupled receptor kinase 5 | Starlite/ChEMBL | References |
Homo sapiens | adrenergic, beta, receptor kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0128 | 0.11 | 0.0496 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0645 | 1 | 0.5 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.014 | 0.1305 | 0.0715 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0645 | 1 | 0.5 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0167 | 0.177 | 0.0752 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0645 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0167 | 0.177 | 0.177 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0645 | 1 | 0.5 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0128 | 0.11 | 0.0496 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0128 | 0.11 | 0.11 |
Loa Loa (eye worm) | hypothetical protein | 0.0645 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0128 | 0.11 | 0.11 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.014 | 0.1305 | 0.023 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.014 | 0.1305 | 0.023 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0645 | 1 | 0.5 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0645 | 1 | 0.5 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.014 | 0.1305 | 0.0715 |
Echinococcus multilocularis | lysosomal protective protein | 0.0645 | 1 | 1 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0645 | 1 | 0.5 |
Echinococcus granulosus | lysosomal protective protein | 0.0645 | 1 | 1 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0645 | 1 | 1 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.0581 | 0.8903 | 0.8829 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0167 | 0.177 | 0.0535 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.0581 | 0.8903 | 0.8829 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0645 | 1 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0645 | 1 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0645 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.7 uM | Inhibition of GRK-5 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRET assay | ChEMBL. | 24210504 |
IC50 (binding) | = 17 uM | Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRET assay | ChEMBL. | 24210504 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.